A5100384167- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- Pancreatitis Pathology and Treatment
- Prostate Cancer Treatment and Research
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Plant Water Relations and Carbon Dynamics
- Pharmacological Effects of Natural Compounds
- Diet, Metabolism, and Disease
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Plant responses to elevated CO2
- Gastroesophageal reflux and treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Adipose Tissue and Metabolism
First Affiliated Hospital of Hebei Medical University
2024-2025
Hebei Medical University
2018-2025
WuXi AppTec (China)
2020-2024
Changhai Hospital
2019-2024
Third Affiliated Hospital of Zhengzhou University
2022-2024
Jiangxi Maternal and Child Health Hospital
2013-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Second Military Medical University
2019-2024
Second Affiliated Hospital of Zhejiang University
2023
Abstract Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of cardiopulmonary units. No cure currently available due to an incomplete understanding remodeling. Here we identify CD146-hypoxia-inducible transcription factor 1 alpha (HIF-1α) cross-regulation as key determinant in and PAH pathogenesis. CD146 markedly upregulated pulmonary artery smooth muscle cells (PASMCs/SMCs) proportion severity. expression HIF-1α transcriptional program reinforce each other...
Abstract Since 2005, an unresolved debate has questioned whether R ‐shaped vulnerability curves ( VCs ) might be artefact of the centrifuge method measuring . with ‐shape show loss stem conductivity from approximately zero tension, and if true, this suggests that some plants either refill embolized vessels every night or function well a high percentage permanently embolized. The occur more in species greater than half length segments spun centrifuge. Many have hypothesized embolism is seeded...
This study sought to compare the clinical outcomes of upper versus whole-neck prophylactic irradiation in treatment patients with node-negative nasopharyngeal carcinoma (NPC).Between November 2005 and June 2012, 301 NPC were randomly assigned receive primary plus neck (UNI, 153 patients) or (WNI, 148 patients). Patients both groups received tumor nodal regions, WNI group also lower neck. The main endpoint was control rate between 2 groups.With a median follow-up period 39 months (range, 6-84...
Abstract Imbalance of macrophage polarization plays an indispensable role in acute lung injury (ALI), which is considered as a promising target. Matrix metalloproteinase-9 (MMP-9) expressed the macrophage, and has pivotal secreting inflammatory cytokines. We reported that saquinavir (SQV), first-generation human immunodeficiency virus-protease inhibitor, restricted exaggerated response. However, whether MMP-9 could regulate inhibit by SQV still unknown. focused on important CLP (cecal...
Pancreatic cancer is characterized by occult onset, low early diagnosis rate, rapid progress, and poor prognosis. Due to the response rate PD-L1 expression in pancreatic cancer, therapeutic application of PL-L1 inhibitors greatly limited. In vitro studies showed that increased cells stimulated fluorouracil (5-FU). We aim explore combining effect 5-FU anti-PD-L1 antibody, provide a reference for clinical antibody cancer. current study, male BALB/c mice were adopted construct tumor-bearing...
As a hot topic today, ferroptosis is closely involved in the progression and treatment of cancer. Accordingly, we built prognostic model around to predict overall survival OSCC patients. We used up 6 datasets from 3 different databases ensure credibility model. Then, through differentially expressed, Univariate Cox, Lasso regression analyses, composed nine prognostic-related differently expressed ferroptosis-related genes (CISD2, DDIT4, CA9, ALOX15, ATG5, BECN1, BNIP3, PRDX5 MAP1LC3A) were...
Inflammatory responses are pivotal incidences in hepatic metabolic derangements. However, the underlying mechanism remains elusive. The present study aimed to evaluate role of peroxisome proliferator-activated receptor-gamma, coactivator 1 alpha (PGC1α) IL10-mediated anti-inflammatory response, and its steatosis insulin resistance. Hepatocyte-specific PGC1α knock-in (LivPGC1α) mice control were fed high-fat diet (HFD) for 8 weeks. IL-10 neutralizing antibody was injected into liver mice. A...
Evidence is emerging that dysregulation of circulating concentrations homocysteine, an important intermediate in folate and vitamin B12 metabolism, associated with autism spectrum disorder (ASD), but comprehensive assessments correlations disease characteristics have not been reported. Multivariate ordinal regression restricted cubic spline (RCS) models were used to estimate independent between serum folate, levels clinical outcomes severity children ASD. After adjusting for confounding...
Lung cancer is a high-risk malignancy worldwide. The harboring of epidermal growth factor receptor (EGFR) mutations in non-small cell lung (NSCLC) makes EGFR-tyrosine kinase inhibitor (EGFR-TKI) an attractive therapeutic option. However, patients usually suffer the primary and secondary resistance to EGFR-TKI. And molecular alteration still not fully clear needs further study.The GEO database was utilized find differentially expressed genes (DEGs) NSCLC profiles resistant 1st or 2nd...
Chronic kidney disease (CKD) is often associated with muscle atrophy. However, the underlying molecular mechanisms are still not well understood. Here, we treated 5/6-nephrectomized (5/6Nx) rats resveratrol and found that this treatment greatly improves renal function as evidenced by reduced proteinuria cystatin C. Moreover, ameliorates fibrosis reducing transforming growth factor β (TGF-β) connective tissue (CTGF). Meanwhile, atrophy in these 5/6Nx was largely attenuated resveratrol....
Selection of sunflower varieties with greater cadmium (Cd) tolerance and detecting physiological variation under different Cd concentrations are important to study the potential (Helianthus annuus L.) in phytoremediation Cd. The aim this was investigate among four (79−79, 363, 8361, ADT). Photosynthesis determined using a Li−6400 XT portable photosynthesis system. Inductively coupled plasma mass spectrometry used detect accumulation plant parts (leaf, stem root). Subsequently, amount per...
Objectives Due to the government's liberalization of epidemic control, current 2019 novel coronavirus disease (COVID‐19) has started spread widely within China. This study aimed use fetal heart quantification (fetal HQ) technique assess cardiac function and morphology fetuses pregnant women diagnosed with COVID‐19 in early stages pregnancy. Methods Exactly 86 infection pregnancy (COVID‐19 group) 90 healthy (control who underwent echocardiography were prospectively included this study. The HQ...
Evaluating quality of life outcomes following prostate cancer treatment is important because different treatments provide similar survival outcomes. A wide variety surveys are used with an unknown correlation between domain specific and broad instruments. We compared the urinary sexual outcome measures Expanded Prostate Cancer Index Composite, a instrument, to those Incontinence Symptom Sexual Health Inventory for Men, which instruments.A total 640 patients undergoing radical prostatectomy...
Abstract Background and Aim Diabetes mellitus (DM) is a common complication of idiopathic chronic pancreatitis (ICP), which impairs the quality life for patients. This study aimed to identify risk factors develop nomogram DM in ICP help early diagnosis. Methods Idiopathic patients admitted our center from January 2000 December 2013 were included. Cumulative rates calculated by Kaplan–Meier method. Patients randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, identified...
This study aimed to explore potential inflammatory biomarkers for early prediction of necrotizing enterocolitis (NEC) in premature infants.Plasma samples were collected from infants with NEC (n = 30), sepsis 29), and controls without infection 29). The 92 inflammatory-related proteins assessed via high-throughput OLINK proteomics platform.There 11 that significate differences (p < 0.05) among NEC, control preterm infants, which include IL-8, TRAIL, IL-24, MMP-10, CCL20, CXCL1, OPG, TSLP,...
The Expanded Prostate Cancer Index Composite is a validated health related quality of life instrument that commonly administered after prostate cancer treatment. We classified Composite-Short Form sexual summary scores into clinically meaningful groups.A development cohort 561 patients undergoing radical prostatectomy was used to define groups by correlation with their responses on the Sexual Health Inventory for Men. A separate validation 430 compare Composite-Long bother among these group...
Almonertinib Mesilate Tablets (HS-10296, Hansoh Pharma, Shanghai, China) is a novel and selective third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). A phase I study of almonertinib in patients with non-small cell lung cancer (NSCLC) demonstrated linear metabolic trend, good tolerability/safety profile, preliminary antitumor activity. However, the metabolism, excretion, substance balance has not been clearly determined. Here, we investigated...
Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Recent studies have shown its liver protection anti-oxidative effects. The aim this study was explore effect mechanism PC on nonalcoholic steatohepatitis juvenile mice. mouse model fatty disease/ (NAFLD/NASH) established by being fed high-fat diet maternal-offspring manner. granules were prepared quality assessed. main components identified high performance...
Background: Factors such as variations in thyroid carcinoma (THCA) gene characteristics could influence the clinical outcome. Ferroptosis and immunity have been verified to play an essential role various cancers, affect cancer patients' prognosis. However, their relationship progression prognosis of many types THCA remains unclear. Methods: First, we extracted prognosis-related immune-related genes ferroptosis-related from 2 databases for co-expression analysis obtain differentially...