A5100391719- Spectroscopy and Chemometric Analyses
- Water Quality Monitoring and Analysis
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Diabetes Management and Education
- Hormonal Regulation and Hypertension
- Thermoregulation and physiological responses
- Tumors and Oncological Cases
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Adrenal Hormones and Disorders
- Brain Tumor Detection and Classification
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and disorders
- Leaf Properties and Growth Measurement
- Cardiovascular Health and Risk Factors
- Protein Interaction Studies and Fluorescence Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Remote Sensing and Land Use
- Erythrocyte Function and Pathophysiology
- Pericarditis and Cardiac Tamponade
- Advanced Drug Delivery Systems
First Affiliated Hospital of Hebei Medical University
2025
Hebei Medical University
2009-2025
Peking University
2015-2024
Peking University First Hospital
2013-2024
Zhejiang University
2020
First Affiliated Hospital of Xi'an Jiaotong University
2016
First Hospital of Xi'an
2016
Xuzhou Medical College
2014
Chinese PLA General Hospital
2013
Ruijin Hospital
2012
Pancreatic cancer is characterized by occult onset, low early diagnosis rate, rapid progress, and poor prognosis. Due to the response rate PD-L1 expression in pancreatic cancer, therapeutic application of PL-L1 inhibitors greatly limited. In vitro studies showed that increased cells stimulated fluorouracil (5-FU). We aim explore combining effect 5-FU anti-PD-L1 antibody, provide a reference for clinical antibody cancer. current study, male BALB/c mice were adopted construct tumor-bearing...
Grassland degradation has become a common problem worldwide. Several studies have analyzed the effects of nitrogen (N) addition on plant growth in grasslands, but few considered its degraded grasslands. The aim this study was to evaluate N grasslands with different levels Inner Mongolia, China. A 2-year field experiment conducted response Mongolian Steppe. Grasslands four were selected for N-addition treatments (0, 10, 20, 30, 40, 50 g m−2 year−1). Aboveground biomass increased by...
Exogenous intestinal alkaline phosphatase (IAP), an enzyme produced endogenously at the brush edge of mucosa, may mitigate increase in aberrant permeability increased during sepsis. The aim this study was to test efficacy inhibitory effect IAP on acute inflammation and molecular mechanisms underlying ameliorating permeability. We used vivo imaging method evaluate disease status curative IAP. Two Escherichia coli (E.coli) B21 strains, carrying EGFP labeled enhanced green fluorescent protein...
Abstract Aim This study aimed to assess the efficacy and safety of prusogliptin (DBPR108), a novel highly selective dipeptidyl peptidase‐4 inhibitor, in individuals with type 2 diabetes who had not been using glucose‐lowering agents regularly for 8 weeks before screening period. Materials Methods In this multicentre, randomized, double‐blind, phase 3 study, adult patients were randomly assigned receive either DBPR108 100 mg, sitagliptin or placebo once daily during initial 24‐week...
Tracking of free proline (FP)-an indicative substance heavy metal stress in rice leaf-is conducive to improve plant phenotype detection, which has important guiding significance for precise management production. Hyperspectral imaging was used high-throughput screening FP leaves under cadmium (Cd) with five concentrations and four periods. The average spectral were show differences optical properties. Partial least squares (PLS), least-squares support vector machine (LS-SVM) extreme learning...
Objective. Assessing excess adrenal hormones is important in patients with mass. Current screening tests for cortisol are complex, so it cannot be done sometimes due to the limited medical resources. The aim of study was evaluate whether neutrophil-lymphocyte ratio (NLR) can used as an initial biomarker Cushing’s syndrome (CS) Methods. This retrospective included a total 185 CS and nonfunctional adenoma (matched 1 : by sex, body mass index, discharge date). NLR compared between two groups....
To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore effect naloxone postconditioning on MIRI. Forty male Sprague Dawley rats were randomly divided into five groups: sham operation (sham, n=8); (IR, IR+naloxone 0.5 mg/kg (Nal L, 1.0 M, 2.0 H, n=8). Pathological changes tissue visualized by HE staining. The expression p-JNK, apoptosis cardiomyocytes investigated with Western blotting TUNEL assay,...
Both the mother and infant are negatively impacted by macrosomia. Macrosomia is three times as common in hyperglycemic mothers normal mothers. This study sought to determine why experienced higher Methods: Hematoxylin Eosin staining was used detect placental structure of mother(NN), who gave birth macrosomia(NM), macrosomia had hyperglycemia (DM). The gene expressions different groups were detected RNA-seq. differentially expressed genes (DEGs) screened with DESeq2 R software verified...
It has been reported that rs940494 and rs805296 SNPs of apolipoprotein M (apoM) gene may confer the risk in development type 2 diabetes (T2D) coronary artery disease (CAD) Han Chinese. However, a recent study demonstrated rs805297 polymorphism is significantly associated with reduced total high density lipoprotein (HDL) levels rheumatoid arthritis patients. But relationship between SNP CAD not explored. The aim present was to elucidate whether mutant allele implicated links changes blood...
To analyze the clinical manifestations of primary adrenal insufficiency in Chinese boys, to investigate prevalence DAX1 and SF1 gene mutations, explore association between mutations manifestations.A total 25 boys with were enrolled. Mutational analysis genes was done by direct sequencing.DAX1 found 40% (10 25) 46,XY phenotypic referred insufficiency, six these novel. One mutation identified. These patients demonstrated diverse presentations. There no definite genetic mutations.DAX1 are a...
Dehydroepiandrosterone-fatty acyl esters (DHEA-FAE) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives that are transported in circulating lipoproteins and may act as source dehydroepiendrosterone (DHEA) other biologically active hormones cells. Here, we studied the metabolic fate low-density lipoprotein-associated [(3)H]DHEA-FAE ([(3)H]DHEA-FAE-LDL) possible role lysosomal acid lipase (LAL) hydrolysis DHEA-FAE cultured human When HeLa cells were...
Objective: DBPR108, a novel dipeptidyl-peptidase-4 inhibitor, has shown great antihyperglycemic effect in animal models. This study was to evaluate the efficacy and safety of DBPR108 monotherapy type 2 diabetes mellitus (T2DM).Methods: 12-week, double-blind, placebo-controlled phase II clinical trial. The newly diagnosed or inadequately controlled untreated T2DM patients were randomized receive 50, 100, 200 mg placebo ratio 1:1:1:1. primary outcome HbA1c change from baseline week 12....
Background: Primary pericardial mesothelioma is an extremely rare tumor, and early identification accurate diagnosis may improve its clinical outcome. Case presentation: In this study, we reported a case of 70-year-old woman who presented with dyspnea. Conventional transthoracic echocardiography showed massive effusion. Contrast-enhanced ultrasonography revealed hyper-enhancing mass in the pericardium. Further imaging methods, including cardiac MRI positron emission tomography/computed...
Kikuchi-Fujimoto lymphadenitis, also known as disease (KFD), is a self-limited lymphoproliferative disease, with no definitive causative agent confirmed by traditional methods.To further explore the clinicopathologic features of KFD and clarify related pathogenic factors.A retrospective analysis was performed in collection cases to review clinical histopathologic features, metagenomic next-generation sequencing (mNGS) used 64 formalin-fixed, paraffin-embedded (FFPE) tissues from patients...