A5024781437- Sulfur Compounds in Biology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Diverticular Disease and Complications
- Environmental remediation with nanomaterials
- Advanced oxidation water treatment
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Appendicitis Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Pregnancy and Medication Impact
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Microbial bioremediation and biosurfactants
- Ureteral procedures and complications
- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Vitamin D Research Studies
- Cancer Genomics and Diagnostics
Lanzhou Jiaotong University
2025
Peking University
2015-2024
Peking University First Hospital
2015-2024
China University of Petroleum, East China
2022-2024
Hefei University of Technology
2023
South China University of Technology
2023
Capital Medical University
2023
Institute of Navigation
2021
University of Science and Technology of China
2017
Fudan University
2008-2014
Smart nanocarriers are of particular interest for highly effective photodynamic therapy (PDT) in the field precision nanomedicine. Nevertheless, a critical challenge still remains exploration potent PDT treatment against hypoxic tumor. Herein, light‐triggered clustered polymeric vesicles photoinduced tumor ablation demonstrated, which able to deeply penetrate into and simultaneously afford oxygen supply upon light irradiation. Hydrogen peroxide (H 2 O ) poly(amidoamine) dendrimer conjugating...
Colorectal cancer (CRC) is the third most common worldwide. The opening of TCGA and GEO databases has promoted progress CRC prognostic assessment, while aging-related risk signature never been mentioned.R software packages, GSEA software, Venn diagram, Metascape, STRING, Cytoscape, cBioPortal, TIMER GeneMANIA website were used in this study.Aging-related gene sets, GO_AGING, GO_CELL_AGING GO_CELLULAR_SENESCENCE, activated significantly tissues. We constructed an using LASSO COX regression...
Abstract Immunotherapy can elicit robust anticancer responses in the clinic. However, a large proportion of patients with colorectal cancer do not benefit from treatment. Although previous studies have shown that hydrogen sulfide (H2S) is involved development and immune escape, further insights into mechanisms related molecules are needed to identify approaches reverse tumor-supportive functions H2S. Here, we observed significantly increased H2S levels tissues. Decreasing by using CBS+/−...
The utility of cell-free nucleic acids in monitoring cancer has been recognized by both scientists and clinicians. In addition to human transcripts, a fraction plasma were proven be derived from microbes reported have relevance cancer. To obtain better understanding RNAs (cfRNAs) patients, we profiled cfRNAs ~300 samples 5 types (colorectal cancer, stomach liver lung esophageal cancer) healthy donors (HDs) with RNA-seq. Microbe-derived consistently detected different computational methods...
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types cancer. However, role colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between and vitamin D receptor (VDR) signaling. Considering pivotal VDR signaling epithelium both physiologically pathologically, correlation may have an important development In this study, underlying mechanisms were investigated vitro vivo. results that able to inhibit expression through...
Recently, long noncoding RNA (lncRNA) H19 has been reported to be related with VDR signaling and the development of inflammatory diseases including osteoarthritis. The aim this study was investigate correlation between expression level in ulcerative colitis (UC) tissues effect overexpression on intestinal epithelial barrier function. H19, miR-675-5p, UC paired normal collected from 12 patients investigated by quantitative real-time polymerase chain reaction. Caco-2 monolayers were used test...
Introduction Anal fissure is a common colorectal disease impacting patients' life quality with high incidence. Social media platforms are becoming kind of health information source nowadays. This study aims to evaluate and compare the anal fissure-related videos on TikTok YouTube. Materials methods One hundred were sourced from YouTube, respectively screened further. The completeness six types content within assessed, including definition disease, symptoms, risk factors, evaluation,...
During cancer progression, tumorigenic and immune signals are spread through circulating molecules, such as cell-free DNA (cfDNA) RNA (cfRNA) in the blood. So far, they have not been comprehensively investigated gastrointestinal cancers. Here, we profile 4 categories of omics data from patients with colorectal stomach adenocarcinoma then assay 15 types genomic, epigenomic, transcriptomic variations. We find that multi-omics more appropriate for detection genes compared single-omics data. In...
Background: As the third confirmed gaseous transmitter, role of hydrogen sulfide (H2S) in pathogenesis multiple types cancer has been attracting increasing attention. Increased expression cystathionine β-synthase (CBS) and H2S colon tissue samples validated tumor-derived H2S, mainly produced by CBS, stimulates bioenergetics, cell proliferation, angiogenesis cancer. Recently, therapeutic manipulation proposed as a promising anticancer approach. However, effect aminooxyacetic acid (AOAA),...
Abstract Background Cell‐free long RNAs in human plasma and extracellular vesicles (EVs) have shown promise as biomarkers liquid biopsy, despite their fragmented nature. Methods To investigate these cell‐free (cfRNAs), we developed a cost‐effective cfRNA sequencing method called DETECTOR‐seq (depletion‐assisted multiplexed total RNA sequencing). utilised meticulously tailored set of customised guide to remove large amounts unwanted (i.e., ribosomal mitochondrial RNAs) plasma. Early barcoding...
Smart nanocarriers attract considerable interest in the filed of precision nanomedicine. Dynamic control interaction between and cells offers feasibility that situ activates cellular internalization at targeting sites. Herein, we demonstrate a novel class enzyme-responsive asymmetric polymeric vesicles self-assembled from matrix metalloproteinase (MMP)-cleavable peptide-linked triblock copolymer, poly(ethylene glycol)-GPLGVRG-b-poly(ε-caprolactone)-b-poly(3-guanidinopropyl methacrylamide)...
Long non-coding RNA-imprinted maternally expressed transcript (non-protein coding) (H19) has been previously identified to be involved in the development of a number types cancer. However, function H19 pathogenesis colorectal cancer remains unclear. The expression level tumor tissues, and association between clinicopathological variables prognosis was investigated present study. In addition, effect overexpression on viability, migration epithelial-mesenchymal transition (EMT) colon cells...
Inflammation is tightly regulated by nuclear factor-kappa B (NF-kappaB), and if left unchecked excessive NF-kappaB activation for cytokine overproduction can lead to various pathogenic consequences including carcinogenesis. A proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), be used explore possible mechanisms whereby unknown functional pathways modulate the activity regulating TNF-alpha-induced inflammation. Given multifunctional nature of 14-3-3 family proteins recent...
Long non‑coding RNA (Lnc)TCF7 is a novel lncRNA that involved in tumorigenesis. Previous studies have revealed lncTCF7 serves an essential role maintaining cancer stem cell self‑renewal; however, the functions of colorectal (CRC) remain unknown. Therefore, present study aimed to investigate CRC. LncTCF7 was upregulated 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis tumor‑node‑metastasis stage Knocking down colon lines decreased proliferation, migration...