A5071335665- Colorectal Cancer Surgical Treatments
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Sulfur Compounds in Biology
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Cardiac tumors and thrombi
- RNA modifications and cancer
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Medical Research and Treatments
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Xenotransplantation and immune response
- Barrier Structure and Function Studies
- Epigenetics and DNA Methylation
Peking University
2016-2025
Peking University First Hospital
2016-2025
Sichuan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Third Xiangya Hospital
2024
Central South University
2024
Anhui Provincial Hospital
2023-2024
Nanjing Audit University
2023
Cancer Research Center
2019
University of Minnesota
2003-2007
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types cancer. However, role colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between and vitamin D receptor (VDR) signaling. Considering pivotal VDR signaling epithelium both physiologically pathologically, correlation may have an important development In this study, underlying mechanisms were investigated vitro vivo. results that able to inhibit expression through...
Recently, long noncoding RNA (lncRNA) H19 has been reported to be related with VDR signaling and the development of inflammatory diseases including osteoarthritis. The aim this study was investigate correlation between expression level in ulcerative colitis (UC) tissues effect overexpression on intestinal epithelial barrier function. H19, miR-675-5p, UC paired normal collected from 12 patients investigated by quantitative real-time polymerase chain reaction. Caco-2 monolayers were used test...
Background: As the third confirmed gaseous transmitter, role of hydrogen sulfide (H2S) in pathogenesis multiple types cancer has been attracting increasing attention. Increased expression cystathionine β-synthase (CBS) and H2S colon tissue samples validated tumor-derived H2S, mainly produced by CBS, stimulates bioenergetics, cell proliferation, angiogenesis cancer. Recently, therapeutic manipulation proposed as a promising anticancer approach. However, effect aminooxyacetic acid (AOAA),...
Increased xCT and transsulfuration pathway has been associated with metabolic reprogramming of colorectal cancer. However, the correlation between these 2 events underlying molecular mechanism remains obscure. expression was determined in tissue microarrays RNA sequencing functional assays vitro adopted to delineate involvement proper function maintaining chemoresistant phenotype. The synthetic lethality blocking investigated both vivo. up-regulation after inhibiting colon cancer cells...
As one of the most common malignant tumors, it is particularly important to further understand development mechanism gastric cancer and find more effective therapeutic target genes. The results immunohistochemical staining showed that PSMC2 was upregulated in cancer. Cell function experiments indicated knockdown inhibited proliferation, clone formation migration cells, induced apoptosis. In vivo suppressed tumor growth. RPS15A mTOR pathway were identified downstream gene by GeneChip IPA....
<title>Abstract</title> Objective This study aimed to show the clinicopathological characteristics of large retroperitoneal liposarcoma (RLS) and developed a customized nomogram model for those patients. Methods A total 1735 patients diagnosed with RLS were selected from Surveillance, Epidemiology, End Results (SEER) database. Among them, 1113 maximum tumor diameter greater than 150 mm included further analysis. Nomogram models based on lasso multivariate cox regression analyses. The 166...
Long non-coding RNA-imprinted maternally expressed transcript (non-protein coding) (H19) has been previously identified to be involved in the development of a number types cancer. However, function H19 pathogenesis colorectal cancer remains unclear. The expression level tumor tissues, and association between clinicopathological variables prognosis was investigated present study. In addition, effect overexpression on viability, migration epithelial-mesenchymal transition (EMT) colon cells...
Liver cancer is a deadly malignancy associated with high mortality and morbidity. Less than 20% of patients advanced liver respond to single anti-PD-1 treatment. The heterogeneity neutrophils in the tumor immune microenvironment may contribute resistance checkpoint blockade (ICB). However, underlying mechanism remains largely unknown.We established an orthotopic model by using transposable elements integrate oncogenes Myc KrasG12D into genome cells from conditional Trp53 null/null mice...
Abstract Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized by the overexpression of HER2. To date, few specific targeted therapies have demonstrated durable efficacy in HER2-positive patients, with resistance to trastuzumab typically emerging within 1 year. However, mechanisms remain incompletely understood, presenting significant challenge clinical practice. Methods In this study, we integrated genetic...
We previously identified a novel lncRNA, CRART16, that could induce cetuximab resistance in colorectal cancer cells. This study explored the relationship of CRART16 expression to gastric progression and molecular mechanisms involved.We evaluated tissues adjacent normal from TCGA database our hospital. Besides, we assessed its with overall survival (OS) patients cancer. The effects on angiogenesis were determined by endothelial tube formation assay, spheroid sprouting HUVEC invasion chick...
Abstract Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis. However, monotherapy of CDK4/6 inhibitors has shown limited antitumor effects for GC, and combination treatments were urgently needed inhibitors. Methods Here, we performed comprehensive analysis, including drug screening, pan-cancer genomic dependency epigenetic sequencing to identify candidate with Mechanisms...
This study explores whether
Abstract Aim This study aimed to analyse the potential significance of metastasis inferior mesenteric artery lymph node (IMA‐LN) in patients with malignancy left colon and rectum. Method A retrospective analysis a cohort 890 collected prospectively who underwent radical resection primary tumour descending colon, sigmoid rectum our department from 1 January 2009 31 December 2015 was performed. Patients were divided into an IMA‐LN ( IMA ‐ LN (+)) group n = 51) non (IMA‐LN (‐)) 839). total 801...
Endogenous H2S regulates multiple physiological and pathological processes in colon epithelial tissues. The current study investigated the role of cystathionine β-synthase [CBS], a major producer cells, pathogenesis ulcerative colitis [UC]-related intestinal barrier injury. expression DNA methylation level CBS were inflamed non-inflamed tissues collected from UC patients, effect decreased levels on Caco-2 monolayer injury altered status tight junctions elicited by tumour necrosis...