A5101483944- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Systemic Lupus Erythematosus Research
- Plant Virus Research Studies
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Acute Kidney Injury Research
- Immune Cell Function and Interaction
- Plant and Fungal Interactions Research
- Sepsis Diagnosis and Treatment
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Syphilis Diagnosis and Treatment
- Noise Effects and Management
- Energy, Environment, and Transportation Policies
- Electrolyte and hormonal disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
- Immune cells in cancer
- Air Quality Monitoring and Forecasting
- Animal Virus Infections Studies
- Reproductive Health and Contraception
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Peking University
2015-2025
Peking University Third Hospital
2015-2025
Beijing Friendship Hospital
2023
Capital Medical University
2023
Beijing Obstetrics and Gynecology Hospital
2023
Shanxi Agricultural University
2018-2021
Jilin University
2019
Nanjing Tech University
2015
Tokyo Institute of Technology
2009
Abstract Histone lactylation is a metabolic stress‐related histone modification. However, the role of in development sepsis‐associated acute kidney injury (SA‐AKI) remains unclear. Here, H3K18 (H3K18la) elevated SA‐AKI, which reported this study. Furthermore, lactate‐dependent modification enriched at promoter Ras homolog gene family member A (RhoA) and positively correlated with transcription. Correction abnormal lactate levels resulted reversal RhoA. Examination related mechanism revealed...
Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Due to its variable and non-specific clinical symptoms, the often overlooked underreported. To date, identification of C. burnetii as causative pathogen using targeted next-generation sequencing (tNGS) has not been previously documented. tNGS was performed on patients with acute unknown etiology, qPCR confirmed for infection. 112 etiology at Peking University Third Hospital between March 27 September 20, 2024. identified in...
Abstract Antiphospholipid syndrome (APS) is characterized by thrombus formation, poor pregnancy outcomes, and a proinflammatory response. H3K4me3‐related monocytes activation are key regulators of APS pathogenesis. Therefore, H3K4me3 CUT&Tag ATAC‐seq performed to examine the epigenetic profiles. The results indicate that signal chromatin accessibility at FOXJ2 promoter enhanced in an vitro monocyte model stimulation with β2GPI / anti‐β2GPI, which mimics APS, decreases after OICR‐9429...
Abstract Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized by the overexpression of HER2. To date, few specific targeted therapies have demonstrated durable efficacy in HER2-positive patients, with resistance to trastuzumab typically emerging within 1 year. However, mechanisms remain incompletely understood, presenting significant challenge clinical practice. Methods In this study, we integrated genetic...
Objective: To explore the distribution characteristics of Mycoplasma pneumoniae (MP) antibody detection data in hospital, provide reference for prevention and control MP infections. Methods: A single-center retrospective study was conducted on 20 639 patients with suspected infection from March 2017 to February 2024 at outpatient, emergency, inpatient departments Peking University Third Hospital. The age range 0 105 years, 11 286 males 9 353 females. passive agglutination method used detect...
Sepsis-associated acute kidney injury (SA-AKI) is a severe complication in critically ill patients, with complex pathogenesis involving cell cycle arrest, microcirculatory dysfunction, and inflammation. Current diagnostic strategies remain suboptimal. Therefore, this study aimed to evaluate pathophysiology-based biomarkers develop an improved predictive model for SA-AKI. The prospective observational was conducted, enrolling 26 healthy individuals 96 sepsis patients from Peking University...
Background Cholangiocarcinoma (CHOL), a malignant tumor of the biliary system, is particularly concerning due to its high malignancy and poor prognosis, often leading obstructive jaundice. The advent metagenomic sequencing(mNGS) technology has expanded diagnostic capabilities, including identification microbes within tumors their potential role in cancer progression. Objective This study aims explore bacterial composition bile from patients with jaundice different etiologies investigate...
Tomato zonate spot virus (TZSV), a new species of genus Tospovirus, caused significant losses in yield and problems quality many important vegetables ornamentals Southwest China posed serious threat to economic crops for the local farmers. A convenient reliable method was urgently needed rapid detection surveillance TZSV. The nucleocapsid protein (N) TZSV expressed Escherichia coli purified, used as antigen immunize BALB/c mice. Three monoclonal antibodies (mAbs) 3A2, 5D2 5F7 against were...
Abstract Background The adverse effects of particulate air pollution on heart rate variability (HRV) have been reported. However, it remains unclear whether they differ by the weight status as well between wake and sleep. Methods A repeated-measure study was conducted in 97 young adults Beijing, China, were classified body mass index (BMI) normal-weight (BMI, 18.5–24.0 kg/m 2 ) obese (BMI ≥ 28.0 groups. Personal exposures to fine matter (PM 2.5 black carbon (BC) measured with portable...
Abstract Objectives To validate the analytical performance and diagnostic accuracy for non-ST-segment elevation myocardial infarction (NSTEMI) with a new high-sensitivity cardiac troponin I (hs-cTnI) assay on automated light-initiated chemiluminescent (LiCA ® ) platform. Methods Comprehensive validations were performed, 99th percentile upper reference limit (URL) from apparently healthy individuals established. We evaluated of NSTEMI. Results The quantitation (LoQ) 1.9 ng/L (20% CV) 5.1 (10%...
Abstract Background Alterations of the trimethylation histone 3 lysine 4 (H3K4me3) mark in monocytes are implicated development autoimmune diseases. Therefore, purpose our study was to elucidate role H3K4me3‐mediated epigenetics pathogenesis antiphospholipid syndrome (APS). Methods H3K4me3 Cleavage Under Targets and Tagmentation Assay for Transposase‐Accessible Chromatin were performed determine epigenetic profiles. Luciferase reporter assay, RNA immunoprecipitation, pull‐down,...