A5102782776- Radio Frequency Integrated Circuit Design
- Advancements in PLL and VCO Technologies
- Microwave Engineering and Waveguides
- Analog and Mixed-Signal Circuit Design
- Advanced Power Amplifier Design
- Full-Duplex Wireless Communications
- Electromagnetic Compatibility and Noise Suppression
- Photonic and Optical Devices
- Acoustic Wave Resonator Technologies
- Semiconductor materials and devices
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Neural dynamics and brain function
- Magnetic Bearings and Levitation Dynamics
- Energy Harvesting in Wireless Networks
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- GaN-based semiconductor devices and materials
- T-cell and B-cell Immunology
- Semiconductor Lasers and Optical Devices
- Glycosylation and Glycoproteins Research
- Memory and Neural Mechanisms
- Bluetooth and Wireless Communication Technologies
- Circular RNAs in diseases
- Copper-based nanomaterials and applications
Xidian University
2015-2025
Zunyi Medical University
2023
Xinxiang Medical University
2022-2023
Taiyuan University of Technology
2022
China Agricultural University
2017-2020
Henan Provincial People's Hospital
2017-2020
Peking University Third Hospital
2006-2017
Zhengzhou University
2017
Peking University
2006-2017
Liaoning University
2006-2012
Sorafenib is the first‑line treatment for advanced hepatocellular carcinoma (HCC). Since many HCC patients experience drug resistance, there an urgent need to discover more effective therapeutic strategies overcome resistance. Long non‑coding RNAs (lncRNAs) play important role in tumor However, research on of lncRNA H19 sorafenib resistance quite limited. In present study, CCK‑8 assay, RT‑qPCR, EdU staining, immunofluorescence and western blot analysis were used detect effect cells....
Circular RNAs (circRNAs) play a crucial role in the occurrence of several diseases, including autoimmune diseases. However, their primary biliary cholangitis (PBC) remains unclear. Here, we aimed to determine circRNA expression profile plasma from PBC patients and further explore value diagnosing PBC.CircRNA microarrays were used profiles samples 6 healthy controls. Statistical analyses identified differentially expressed circRNAs, these circRNAs verified by qRT-PCR 29 30 MicroRNA (miRNA)...
Hepatocellular carcinoma (HCC) is one of the most widespread malignant human tumors worldwide. Treatment options include radiotherapy, surgical intervention and chemotherapy; however, drug resistance an ongoing treatment concern. In present study, effects a microRNA (miR/miRNA), miR-9, on sensitivity HCC cell lines to epidermal growth factor receptor inhibitor, cetuximab, were examined. miR-9 has been proposed serve role in tumorigenesis tumor progression. bioinformatics analyses identified...
A 5-bit 360° active phase shifter of digital control with a novel two-step vector-sum technique in 0.18μm SiGe process is presented this brief for X-band phased arrays. The based on sub-phase array controlled by high quality logic circuit to avoid the issue low accuracy conventional scheme. implemented features good performance 11.25° resolution and full synthesizing between 8-12 GHz. Measurements display that RMS gain error below 0.6 dB while lower than 4.6°. measured insertion loss less -...
Abstract Recently, many immune-related genes have been extensively studied in ducks, but relatively little is known about their TCR genes. Here, we determined the germline and expressed repertoire of White Peking duck. The genomic organization duck TCRα/δ, TCRγ unconventional TCRδ2 loci are highly conserved with counterparts mammals or chickens. By contrast, TCRβ locus organized an unusual pattern, (Vβ) n -Dβ-(Jβ) 2 -Cβ1-(Jβ) 4 -Cβ2, which differs from tandem-aligned clusters translocon some...
Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AMPA dose-dependently inhibited carbachol (CCH)-induced the rat slices, but underlying mechanism is not clear. Application AMPARs antagonist NBQX (1 μM) did affect power (γ power), nor AMPA-mediated reduction. At 3 μM, had no effect on largely blocked Ca2+-permeable receptor (CP-AMPAR)...
A dual power supply ultra low-power 1 kbits EEPROM for passive UHF RFID is presented. The read source V, while the write 1.65 which only activated in mode. To reduce of circuit without impacting performance, a pre-charge scheme, feedback scheme and self-detect circuit, combined with special time sequence are adopted. time-divided charge pump proposed to current surge at startup phase. IP has been fabricated SMIC <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML"...
IgG subclass diversification is common in placental mammals. It has been well documented humans and mice that different subclasses, with diversified functions, synergistically regulate humoral immunity. However, our knowledge on the genomic functional of subclasses pig, a mammalian species high agricultural biomedical importance, incomplete. Using bacterial artificial chromosome sequencing newly assembled genomes generated by PacBio approach, we characterized mapped IgH C region gene locus...
Serum total bilirubin (TB) has been recognized as a potent endogenous antioxidant under physiological conditions, and serum high sensitive C reactive protein (hs-CRP) is the most commonly used marker which reflects activation of systemic inflammation in body. The study investigated association between these two indicators further evaluated anti-inflammatory effects its clinical significance impaired glucose tolerance (IGT) type 2 diabetes mellitus (T2DM) individuals.A group 94 patients with...
Abstract A 5-bit lumped CMOS step attenuator with low insertion loss and phase distortion is designed simulated in this paper. The proposed based on switched bridged-T π structure attenuators, implemented 0.18-μm technology. Different attenuation states are controlled by NMOS switches. switches series branches have channel-shunt resistance to minimize the on-resistance without increasing parasitic capacitance. shunt body-floated improve power handling performance of attenuator. Each module...
This paper presents a power amplifier (PA) based on the mismatch-consistent magnetically coupled resonator (MCR) technique, which employs adjustable dual-pole to achieve wide operating frequency range. The in-band no gain ripple condition of proposed MCR is systematically analyzed and derived. By applying this flatness in broadband improved. An ultra-wide wiring method for power-combining structure further improve by reducing parasitic effects. Meanwhile, an active matching network without...
Abstract This study was designed to measure the correlation between left ventricular (LV) remodeling 3 months after successful reperfusion therapy, and levels of serum N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) high‐sensitivity C‐reactive protein (hs‐CRP) at days acute myocardial infarction (AMI), determine predictive NT‐proBNP hs‐CRP for LV remodeling. A total 106 patients with first AMI were included in this study. Each patient examined by echocardiography (ECG) on third day...
A 2.4 GHz high-linearity low-phase-noise cross-coupled CMOS LC voltage-controlled oscillator (VCO) is implemented in standard 0.18-μm technology. An equalization structure for tuning sensitivity base on the three-stage distributed biased switched-varactor bank and differential switched-capacitor adopted to reduce variations of VCO gain, achieve high linearity, optimize phase-noise performance. Compared conventional VCO, proposed has more constant gain over entire range. The range about 18.7%...
A wideband high-gain low-noise amplifier (LNA) with improved linearity is presented in this paper. To suppress the gain compression of large signal under high conditions, single-stage cascode topology using resistive shunt-shunt feedback and an emmiter degenerate resistor are adopted. Wideband input matching thus realized conjunction preceding L-type passive network. network inserted between structure load enhances bandwidth as well impedance matching. The LNA based on a 0.18μm SiGe HBT...
This study presents a 3.1–10.6 GHz ultra-wideband low noise amplifier (UWB LNA) in 0.18 µm SiGe HBT technology. To achieve good input match, parasitic base resistance bipolar transistor and an LC-ladder filter are included into calculations with the common-emitter topology using shunt–shunt capacitive feedback. Both high flat power gain (S21) figure (NF) achieved by adjusting pole zero amplifying stage quality factors of fourth-order network. Design equations for performances such as gain,...
Neural network oscillation at gamma frequency band (γ oscillation, 30-80 Hz) is synchronized synaptic potentials important for higher brain processes and altered in normal aging. Recent studies indicate that activation of dopamine 4 receptor (DR4) enhanced hippocampal γ young mice fully recovered the impaired plasticity aged mice, we determined whether this involved aging-related modulation oscillation.We recorded oscillations CA3 region from C57bl6 investigated effects selective (DR)...
Abstract Background Multiple host factors are involved in modulating type I interferon expression induced by viruses; however, the mechanism is not fully elucidated. Influenza A virus infection causes severe respiratory symptoms and triggers a series of signaling cascades innate immune responses, including production. The co-IP/MS technology was used to screen several antiviral early stage. Among these factors, ariadne-1 homolog (ARIH1) caught our attention. Methods Western blot assay...