A5087245330- 14-3-3 protein interactions
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Advanced Proteomics Techniques and Applications
- Mycobacterium research and diagnosis
- Nanomaterials for catalytic reactions
- Industrial Technology and Control Systems
- interferon and immune responses
- Neonatal Respiratory Health Research
- Gear and Bearing Dynamics Analysis
- Fungal Plant Pathogen Control
- vaccines and immunoinformatics approaches
- Adhesion, Friction, and Surface Interactions
- Sulfur Compounds in Biology
- Tribology and Lubrication Engineering
- Advanced Decision-Making Techniques
- NF-κB Signaling Pathways
- Manufacturing Process and Optimization
Northwestern Polytechnical University
2024
Fudan University
2009-2013
Shanghai Business School
2013
University of North Carolina at Chapel Hill
2010
Inflammation is tightly regulated by nuclear factor-kappa B (NF-kappaB), and if left unchecked excessive NF-kappaB activation for cytokine overproduction can lead to various pathogenic consequences including carcinogenesis. A proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), be used explore possible mechanisms whereby unknown functional pathways modulate the activity regulating TNF-alpha-induced inflammation. Given multifunctional nature of 14-3-3 family proteins recent...
The PE/PPE family of proteins which are in high abundance pathogenic species such as Mycobacterium tuberculosis and M. marinum , play the critical role generating antigenic variation evasion host immune responses. However, little is known about their functional roles mycobacterial pathogenesis. Previously, we found that PPE38 associated with virulence mycobacteria, presumably by modulating response. To clarify link between response, employed a subcellular, amino acid-coded mass tagging...
Toll-like receptor 4 (TLR4) specifically recognizes lipopolysaccharide (LPS) to initiate signal transduction events that modulate host inflammatory responses. Although increasing numbers of genes have been characterized individually for their involvement in TLR4 signaling, the LPS-induced TLR4-mediated signaling pathway and connected networks are incompletely delineated. Given most components pathways activated at an early phase response, we employed a subcellular, SILAC-based quantitative...
Lack of understanding the response hepatocellular carcinoma (HCC) to anticancer drugs causes high mortality HCC patients. Bleomycin (BLM) that induces DNA damage is clinically used for cancer therapy, while mechanism underlying BLM-induced (DDR) in cells remains ambiguous. Given 14-3-3 proteins are broadly involved regulation diverse biological processes (BPs)/pathways, we investigate how a isoform coordinates particular BPs/pathways DDR HCC.Using dual-tagging quantitative proteomic...
Major vault protein (MVP) is the predominant constituent of particle, largest known ribonuclear complex. Although emerging evidence have been establishing links between MVP (vault) and multidrug resistance (MDR), little regarding exactly how MDR activity modulated during cellular response to drug-induced DNA damage (DDR). Bleomycin (BLM), an anticancer drug, induces double-stranded breaks (DSBs) consequently triggers DDR. Due its physiological implications in hepatocellular carcinoma (HCC)...
In mammalian cells, when tandem affinity purification approach is employed, the existence of untagged endogenous target protein and repetitive washing steps together result in overall low yield purified/stable complexes loss weakly transiently interacting partners biological significance. To avoid trade-offs involving methodological sensitivity, precision, throughput, here we introduce an integrated method, biotin tagging coupled with amino acid-coded mass tagging, for highly sensitive...
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Due to their exceptional static and dynamic properties along with high-temperature resistance, liquid metal bearings are extensively employed in challenging environments. This paper carried out a multi-objective optimization work for spiral groove journal (JLMB) by using NSGA-II. The clearance of bearing C, angle a, depth h g , ridge ratio β, number N, spacing P were chosen as design variables maximize the load-carrying capacity effective stiffness bearing. During process, Latin hypercube...