A5100348927- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Surgical site infection prevention
- Gallbladder and Bile Duct Disorders
- Tea Polyphenols and Effects
- Orthopedic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Abdominal Trauma and Injuries
- Food Quality and Safety Studies
- Vascular Malformations and Hemangiomas
- Diabetes and associated disorders
- Nanofluid Flow and Heat Transfer
- Intestinal and Peritoneal Adhesions
- Fermentation and Sensory Analysis
- Pharmacology and Obesity Treatment
- Dupuytren's Contracture and Treatments
- Advanced X-ray and CT Imaging
- Acute Lymphoblastic Leukemia research
- Case Reports on Hematomas
- Congenital limb and hand anomalies
- Phytochemicals and Antioxidant Activities
Changhai Hospital
2017-2024
Second Military Medical University
2017-2024
Army Medical University
2024
Yunnan Agricultural University
2023
Chongqing Medical University
2021
Fuzhou University
2020
Affiliated Hospital of Southwest Medical University
2020
Shanghai Pudong New Area Gongli Hospital
2018-2019
Zhejiang University of Technology
2018
Kunming General Hospital of Chengdu Military Command
2017
Circulating tumor cells (CTCs) undergoing epithelial mesenchymal transition (EMT) play an essential role in metastasis and have a better correlation with poor disease outcomes, but the most current affinity-based enrichment methods rely on targeting markers, which are less effective capturing CTCs EMT. Herein, we identified optimized aptamer (ZY5C) sequence high binding affinity specificity against cell surface vimentin (CSV), is overexpressed post-EMT CTCs. Not only can hairpin-structured...
Background Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare natural course alcoholic (ACP) and idiopathic (ICP). Methods CP patients admitted our center from January 2000 December 2013 were enrolled. Characteristics compared between ACP ICP patients. Cumulative rates diabetes mellitus (DM), steatorrhea, pancreatic stone, pseudocyst, biliary stricture, cancer after onset diagnosis calculated, respectively. The cumulative DM steatorrhea...
Tea polyphenol (TPs) oxidation caused by oxidase (PPO) in manufacturing is responsible for the sensory characteristics and health function of fermented tea, therefore, this subject rich scientific commercial interests. In work, an vitro catalysis TPs liquid nitrogen grinding sun-dried green tea leaves PPO was developed, changes metabolites were analyzed metabolomics. A total 441 identified catalyzed powder control check samples, which classified into 11 classes, including flavonoids (125...
We describe a rare case using an ulnar polydactyly with anterolateral thigh flow-through flap to reconstruct amputated thumb.
Utilizing epigenetic (DNA methylation) differences to differentiate between maternal peripheral blood (PBL) and fetal (placental) DNA has been a promising strategy for non-invasive prenatal testing (NIPT). However, the differentially methylated regions (DMRs) have yet be fully ascertained. In present study, we performed genome-wide comparative methylome analysis PBL placental from pregnancies of first trimester by immunoprecipitation-sequencing (MeDIP-Seq) Infinium HumanMethylation450...
To identify the risk factors and develop nomograms for common bile duct (CBD) stricture in chronic pancreatitis (CP) patients.CBD is a complication CP has variable clinical presentation ranging from asymptomatic to overt jaundice cholangitis.Patients with admitted Changhai Hospital (Shanghai, China) January 2000 December 2013 were enrolled. Cumulative rates of CBD after onset diagnosis calculated. Patients randomly assigned, 2:1 ratio, training validation cohort. On basis cohort, symptomatic...
Abstract Background and Aim Pancreatic extracorporeal shock wave lithotripsy (P‐ESWL) is a first‐line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P‐EWSL in geriatric remains unclear. We aimed to evaluate safety efficacy P‐ESWL them. Methods This prospective study was conducted painful CP who underwent P‐ESWL. Patients aged over 65 years were included group; under assigned control group. For long‐term follow‐up investigation, matched...
Abstract Background and Aim Diabetes mellitus (DM) is a common complication of idiopathic chronic pancreatitis (ICP), which impairs the quality life for patients. This study aimed to identify risk factors develop nomogram DM in ICP help early diagnosis. Methods Idiopathic patients admitted our center from January 2000 December 2013 were included. Cumulative rates calculated by Kaplan–Meier method. Patients randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, identified...
Fatigue is a debilitating symptom found in various chronic diseases and associated with more severe symptoms worse quality of life (QoL). However, this has not been adequately addressed pancreatitis (CP), there have no studies on fatigue patients CP. This cross-sectional study was conducted at the Changhai Hospital Shanghai, China. Data patients' sociodemographic, disease, therapeutic characteristics were collected. assessed using Multidimensional Inventory-20. QoL utilizing European...
Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no document natural history CP.CP admitted center January 2000 December 2013 were enrolled. Patients assigned (< 18 years old) adult group according their age at onset Cumulative rates both groups calculated. Risk identified, respectively.The median follow-up duration...
Background: Pancreatic stones are pathognomonic of chronic pancreatitis (CP). This study aimed to determine the incidence, identify risk factors, and develop a nomogram for pancreatic in CP patients. Methods: Patients with admitted our center from January 2000 December 2013 were enrolled. Cumulative rates after onset diagnosis calculated. randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, factors identified through Cox proportional hazards regression model, was...
Background: Bortezomib (BTZ) is a powerful proteasome inhibitor that has been approved for the treatment of haematologic malignancies. Its effectiveness assessed against different types solid tumours. BTZ ineffective in most tumours because drug resistance, including cholangiocarcinoma, which associated with bounce-back effect. However, mechanism through inhibitors induce effect remains largely unknown. Methods: Cholangiocarcinoma cells were treated BTZ, cisplatin, or combination both. The...
Abstract Background The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into nucleus, protein can induce apoptosis of CML cells. coiled-coil domain (CC domain) plays a central role subcellular localization. However, how CC affects localization remains unclear. Methods Herein, key proteins interacting with were screened by immunoprecipitation binding mass spectrometry. specific site to target was predicted Deep Viewer....
Objective The pathogenesis of chronic pancreatitis (CP) is not completely clear. With further studies, smoking toxic to the pancreas. This study classified smoking-related CP as a new etiology and defined cutoff smoking. Design Patients with admitted from January 2000 December 2013 were included in study. characteristics compared between patients, drinking group patients who never smoke or drink (control group). cumulative rates steatorrhea, diabetes mellitus (DM), pancreatic pseudocyst...
The anterolateral thigh flap is one of the most widely used flaps because it has advantages less damage to donor site, no sacrifice main blood vessels, and abundant soft tissue. However, application in children relatively rare small vessels rapid physiological changes. aim this study was explore effectiveness characteristics free for reconstruction extremity tissue defects pediatric patients.This included 26 patients, with an average age 6.7 years (range, 2-13 years). There were 5 cases...
Objectives Steatorrhea, a sign of severe pancreatic exocrine insufficiency (PEI), is related to consequences caused by pancreatitis. This study aimed identify predictors and construct nomogram for steatorrhea in idiopathic chronic pancreatitis (ICP). Methods ICP patients admitted our hospital from January 2000 December 2013 were enrolled this retrospective–prospective cohort randomly assigned the training validation cohorts. The cumulative rate was calculated. A Cox proportional hazard...
Mesenteric hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones is a very rare complication which has never been reported before.We case of 36-year-old male diagnosed as chronic pancreatitis with and large pseudocyst. He underwent 3 repeated sessions ESWL (P-ESWL). After the last session P-ESWL, he complained dizziness. Physical examination revealed mass in right abdomen.Emergent upper abdominal computerized tomography (CT) this mesenteric size 8.2 cm × 11.7...
Abstract Background Despite pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is a minimally invasive treatment for stones, complications exist. Case presentation A 37-year-old male was diagnosed with chronic pancreatitis and admitted to our hospital recurrent acute pancreatitis. After the first P-ESWL session, patient complained of new type pain different from previous pattern. Computerized tomography colonoscopy were arranged colonic hematoma found. Since had stable vital signs, no...
The study concerns identifying risk factors and developing nomogram for pancreatic pseudocyst (PPC) in idiopathic chronic pancreatitis (ICP) to facilitate early diagnosis.From January 2000 December 2013, ICP patients admitted our center were enrolled. Cumulative incidence of PPC was determined by Kaplan-Meier method. Patients randomized into training group validation a 2:1 ratio. Risk through Cox proportional hazards regression model based on cohort. constructed according factors.Totally,...