A5011680450- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Neuroscience of respiration and sleep
- Child Nutrition and Water Access
- Lung Cancer Research Studies
- Erythrocyte Function and Pathophysiology
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Cardiac tumors and thrombi
- Pediatric health and respiratory diseases
- Microtubule and mitosis dynamics
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hernia repair and management
- Neonatal skin health care
- ATP Synthase and ATPases Research
- Congenital gastrointestinal and neural anomalies
- Emergency and Acute Care Studies
- Appendicitis Diagnosis and Management
- Sleep and Wakefulness Research
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
Medical College of Wisconsin
2022-2024
Children's Hospital of Wisconsin
2023-2024
Vanderbilt University Medical Center
2014-2019
Vanderbilt University
2015-2016
Monroe Carell Jr. Children's Hospital
2016
Children's Hospital of Pittsburgh
2011-2013
University of Pittsburgh
2006-2013
Washington University in St. Louis
2010
A replication-defective lentivirus vector that expresses enhanced green fluorescent protein (EGFP) under the control of a synthetic dopamine-beta-hydroxylase (DbetaH) promoter was used to define efferent projections C1 catecholamine neurons in rat rostral ventrolateral medulla (RVLM). EGFP expression restricted and filled their somatodendritic compartments axons 7-28 days after injection. This included descending thoracic spinal cord network brainstem, midbrain, diencephalon. In caudal...
Necrotizing enterocolitis (NEC) develops in response to elevated TLR4 signaling the newborn intestinal epithelium and is characterized by TLR4-mediated inhibition of enterocyte migration reduced mucosal healing. The downstream processes which impairs healing remain incompletely understood. In other systems, induces autophagy, an adaptive cellular stress. We now hypothesize that autophagy enterocytes TLR4-induced plays a critical role NEC development. Using mice selectively lacking...
As non-operative management of acute appendicitis in children has become more common, missed incidental appendiceal pathology can be an unintended consequence. We assessed the prevalence neuroendocrine tumors appendectomy specimens from eight US children's hospitals 2012 to 2021. The (NET) was found 1:271, with a median age 14 years and 62% female. Most were small (median 6 mm; interquartile range [IQR]: 3-10), no recurrence noted during follow-up period 22.5 months; IQR: 3-53). possibility...
Abstract Purpose Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) those residual nodules after induction chemotherapy (non‐RCR). Patients methods This retrospective cohort study included children under 20 years EWS treated from 2007 2020 19 institutions in the Pediatric Surgical Oncology Research Collaborative. Chi‐square tests conducted for differences among...
// Eric J. Rellinger 1, 6 , Chandrasekhar Padmanabhan 1 Jingbo Qiao Brian T. Craig Hanbing An Jing Zhu Hernán Correa 2 Alex G. Waterson 3 W. Lindsley R. Daniel Beauchamp 4, 5 and Dai H. Chung Section of Surgical Sciences, Department Surgery, at Vanderbilt University Medical Center, TN 37232, Nashville, USA Pathology, Pharmacology Institute Chemical Biology, 4 Cancer Cell Developmental Pediatric Correspondence to: Chung, email: dai.chung@vanderbilt.edu Beauchamp,...
Abstract Surgery is a cornerstone of induction therapy in high-risk neuroblastoma (HR-NBL). Local relapse decreased by gross total resection, however metastatic unaffected extent surgery. Whether and how surgery may be impacting pre-existing distant disease HR-NBL remains unknown. We added to an established mouse model test the hypothesis that surgery-induced immune dysregulation functions as pro-tumoral stimulus. MYCN-amplified 9464D murine cells derived from Th-MYCN are syngeneic competent...
Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted the past 2 decades. Although open/incisional biopsies used to be predominant approach obtain material Ewing sarcoma and osteosarcoma, image-guided core needle increased frequency are safe patients. These procedures less invasive reduce recovery times but potential limitations. The quantity quality of tissue obtained through these vary between institutions. Acquired viable volumes can low, limiting...
Omphalitis is an infrequent neonatal infection of the umbilicus. Necrotizing infections are a rare complication omphalitis that requires prompt antibiotic therapy, surgical debridement, and supportive care. Here, we present case Clostridium sordellii necrotizing progressed to severe toxemia characterized by refractory hypotension, massive capillary leak, leukemoid reaction, absence fever. These clinical features common in C. harbor poor prognosis with only one reported survivor (out 12)...
Foregut duplications occur at various locations throughout the upper gastrointestinal tract, including thoracic cavity. Thoracic foregut are typically intimately associated with esophagus and therefore located in either posterior mediastinum or pleural Here we report a case of duplication middle mediastinum, pericardium great vessels that contained gastric mucosa, ciliated respiratory epithelium, bronchial-type pancreatic tissue hepatocytes. The literature mediastinal is also reviewed.