A5089937416- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Intraperitoneal and Appendiceal Malignancies
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Appendicitis Diagnosis and Management
- Renal and related cancers
- Cystic Fibrosis Research Advances
- Intestinal Malrotation and Obstruction Disorders
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Vector-borne infectious diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Arrest and Resuscitation
- Nonmelanoma Skin Cancer Studies
- Mechanical Circulatory Support Devices
- Cardiac tumors and thrombi
- Gut microbiota and health
- Abdominal Surgery and Complications
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- Pediatric Hepatobiliary Diseases and Treatments
- Testicular diseases and treatments
University of Pittsburgh
2022-2024
Pittsburg State University
2024
Children's Hospital of Pittsburgh
2022-2024
University of Pittsburgh Medical Center
2022-2023
The Ohio State University
2019-2021
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021
Nationwide Children's Hospital
2017-2021
University of California, San Diego
2020
Regorafenib is an inhibitor of multiple kinases with aberrant expression and activity in neuroblastoma tumours that have potential roles pathogenesis.
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare tumor for which there are few evidence-based guidelines. The aim this study was to define current management strategies and outcomes these patients using multi-institutional dataset curated by Pediatric Surgical Oncology Research Collaborative.
Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered B. cenocepacia cannot be cleared from CF macrophages due to defective autophagy, causing continued systemic inflammation infection. Defective autophagy is mediated through constitutive reactive oxygen species (ROS) activation transglutaminase-2 (TG2), which causes sequestration (accumulation) essential...
Abstract Purpose Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) those residual nodules after induction chemotherapy (non‐RCR). Patients methods This retrospective cohort study included children under 20 years EWS treated from 2007 2020 19 institutions in the Pediatric Surgical Oncology Research Collaborative. Chi‐square tests conducted for differences among...
BACKGROUND:Optimal management of neutropenic appendicitis (NA) in children undergoing cancer therapy remains undefined. Management strategies include upfront appendectomy or initial nonoperative management. We aimed to characterize the effect strategy on complications and length stay (LOS) describe implications for chemotherapy delay alteration.
Objective: The purpose of this study was to describe management and outcomes from a contemporary cohort children with Wilms Tumor (WT) complicated by inferior vena caval thrombus. Summary Background Data: largest series these patients published almost two decades ago. Since then, neoadjuvant chemotherapy has been commonly used manage have not reported. Methods: Retrospective review 19 North American centers between 2009-2019. Patient disease characteristics, management, were investigated...
Objective: To determine the impact of nodal basin ultrasound surveillance (US) versus completion lymph node dissection (CLND) in children and adolescents with sentinel (SLN) positive melanoma Summary Background Data: Treatment for are extrapolated from adult trials. However, there is increasing evidence that important clinical biological differences exist between pediatric melanoma. Methods: Patients ≤18 years diagnosed cutaneous 2010-2020 14 hospitals were included. Data extracted included...
As non-operative management of acute appendicitis in children has become more common, missed incidental appendiceal pathology can be an unintended consequence. We assessed the prevalence neuroendocrine tumors appendectomy specimens from eight US children's hospitals 2012 to 2021. The (NET) was found 1:271, with a median age 14 years and 62% female. Most were small (median 6 mm; interquartile range [IQR]: 3-10), no recurrence noted during follow-up period 22.5 months; IQR: 3-53). possibility...
18F-fluorodeoxyglucose (FDG) is a glucose analog that acts as marker for uptake and metabolism. FDG PET scans are used in monitoring pediatric cancers. The handheld probe localization of FDG-avid lesions an emerging modality radio-guided surgery (RGS). We sought to assess the utility localizing occult tumors patients. functionality was evaluated by using PET/CT scan calibration phantom. able detect photon emission from simulated with expected decay radioisotope over time. Specificity tumor...
Leptomeningeal carcinomatosis (LMC), a common complication of advanced malignancies, is associated with high morbidity and mortality, yet diagnosis treatment decisions remain challenging. This study describes the diagnostic modalities for LMC identifies factors overall survival (OS).We performed single-institution retrospective (registration #: OSU2016C0053) 153 patients diagnosed treated at The Ohio State University, Comprehensive Cancer Center, (OSUCCC)-James between January 1, 2010...
Abstract Wilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent patients present metastatic disease, commonly to lungs. The presence a pleural effusion at time diagnosis may be noted on staging imaging; however, minimal data exist regarding significance and prognostic importance this finding. objectives our study are identify incidence effusions WT, determine potential impact oncologic...
We present the case of a successful liver transplant in young adult patient with cholestasis and cirrhosis secondary to severe pyruvate kinase (PK) deficiency. Liver resulted resolution dysfunction, decreased need for blood transfusions eligibility bone marrow transplantation. This represents third reported literature PK deficiency who successfully underwent as result profound failure. Explant pathology demonstrated lack significant iron deposition indicating that predisposes injury...
e13554 Background: Leptomeningeal carcinomatosis (LMC) is a complication of advanced malignancies wherein primary tumors metastasize to the leptomeninges surrounding brain and spinal cord. LMC complicates 4-15% malignant solid with incidence increasing as survival patients cancer improves. Diagnostic methods include magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) cytology. MRI findings may be nonspecific, gold standard diagnosis cytology on CSF analysis. We assessed detection...
Abstract BACKGROUND: Leptomeningeal carcinomatosis (LMC) is a complication of solid tumor malignancies where tumors metastasize to the leptomeninges. LMC complicates 4–15% with incidence increasing as survival patients advanced cancer improves. Diagnostic methods include magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology. We assessed detection methods, incidence, outcomes at The Ohio State University Comprehensive Cancer Center from 2005–2015. METHODS: This was...
Objective: We describe a patient with Lyme neuroborreliosis (LNB) who presented clinical and radiographic findings initially suggestive of cavernous sinus syndrome. Background: disease is tick-borne illness increasing incidence in the United States. Nervous system involvement, or LNB, can present lymphocytic meningitis cranial neuropathies, seventh nerve most commonly affected. Design/Methods: NA Results: A 73-year-old man one week right eye pain swelling, blurry vision, diplopia, headache....
Abstract Background Leptomeningeal carcinomatosis (LMC) is a complication of advanced malignancies wherein metastatic disease invades the meninges central nervous system via contiguous spread from bone or brain metastases hematogenous systemic disease. Breast cancer most common solid tumor etiology LMC. Approximately 5% patients (pts) with breast develop LMC has median survival 4 weeks when untreated and 8-16 treatment. The diagnosis remains challenging only 60% pts having cerebrospinal...
Abstract Purpose Leptomeningeal carcinomatosis (LMC), a common complication of advanced malignancies, is associated with high morbidity and mortality, yet diagnosis treatment decisions remain challenging. This study describes the diagnostic modalities for LMC identifies factors overall survival (OS). Methods We performed single-institution retrospective 153 patients diagnosed treated at The Ohio State University between January 1, 2010 December 31, 2015. Results Median age was 55.7 years,...