A5027676114- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Testicular diseases and treatments
- Blood groups and transfusion
- Brain Metastases and Treatment
- Hemophilia Treatment and Research
- Renal and related cancers
- Central Venous Catheters and Hemodialysis
- Neutropenia and Cancer Infections
- Chromatin Remodeling and Cancer
- Food Security and Health in Diverse Populations
- Reproductive Health and Contraception
- Ocular Oncology and Treatments
- Sarcoma Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Myeloid Leukemia Research
Nationwide Children's Hospital
2016-2025
The Ohio State University
2015-2025
Karolinska Institutet
2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Montréal
2024
Seattle Children's Hospital
2023
Seattle University
2023
University of Washington
2023
University of Toledo Medical Center
2021
Cancer Research And Biostatistics
2018-2019
OBJECTIVES In 2009, a large multicenter study demonstrated that the rate of pediatric venous thromboembolism (VTE) across US children’s hospitals had significantly increased from 2001 to 2007. The objective this was evaluate VTE 2008 2019 using similar methodology. METHODS A retrospective cohort Pediatric Health Information System (PHIS) database. Subjects birth <18 years admitted through who an ICD-9-CM or ICD-10-CM code for were included. Demographics, underling medical...
ABSTRACT Background Neuroblastoma is the most common extracranial solid tumor in children, with about half of cases classified as high risk. Treatment varies by risk level, high‐risk patients undergoing aggressive multimodal therapy. While long‐term survival has improved, survivors face significant risks late treatment effects, including adrenal insufficiency. This study investigates incidence insufficiency among neuroblastoma varying disease Procedure retrospective cohort at a single...
Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promotion antitumor T responses. Solid tumors limit the effectiveness immunotherapeutics in diverse ways such as secretion immunosuppressive expression immune inhibitory ligands to inhibit function. Blocking programmed death protein (PD)-1 signaling, which mediates suppression engagement...
Menstruating women, with or without underlying bleeding disorders, are at increased risk for developing iron deficiency-related fatigue, even in the absence of anemia. Oral therapy has limitations which include poor absorption and non-adherence due to gastrointestinal side effects. We performed a prospective clinical trial post-menarchal adolescent females iron-deficiency mild anemia fatigue who received standardized regimen intravenous sucrose. The baseline mean (SD) hemoglobin was 11.96 g...
Abstract Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state. Despite the increased risk of venous thromboembolism in SCD population, there is limited evidence available guide thromboprophylaxis (TP) practices these patients. This study aimed assess use pharmacologic and nonpharmacologic TP adolescent patients using Pediatric Health Information System (PHIS). We hypothesized that was increasingly used hospitalized SCD. The included aged 13 21 years, admitted...
Key Points Adults with SCD have an increased incidence of VTE, but similar data in children are lacking. In this 7-year, multicenter retrospective study, 1.7% developed VTE.
United States studies documenting time interval from symptom onset to definitive diagnosis for childhood central nervous system (CNS) tumors are more than a quarter-century old. The purpose of this study is establish an accurate and contemporary Ohio baseline the diagnostic children with newly diagnosed CNS tumors.Medical records were retrospectively reviewed 301 January 2004 August 2015 at Nationwide Children's Hospital. We obtained comprehensive data on 171 patients (56.8%). Records age,...
Background: Needles are frequently required for routine medical procedures. Children with severe hemophilia require intensive intravenous (IV) therapy to treat and prevent life-threatening bleeding undergo hundreds of IV Fear needle-related procedures may lead avoidance future health care poor clinical outcomes. Virtual reality (VR) is a promising distraction technique during procedures, but barriers commercially available VR platforms pediatric purposes have prevented widespread use....
To develop an improved interictal electroencephalogram (EEG) grading scale for children with infantile spasms founded on elements adequate inter-rater reliability (IRR) to justify its further study clinical and research purposes.Three blinded reviewers assessed five-minute sleep epochs in 93 EEGs from 62 (31 consecutive controls, 31 [pretreatment posttreatment studies]) using a longitudinal bipolar montage. We determined the IRR of background amplitude, epileptiform discharges, >3 spike foci...
Anti-GD2 immunotherapy has improved outcomes for children with high-risk neuroblastoma (HRNBL). Dinutuximab promotes complement-mediated reaction against disialoganglioside GD2, which is expressed in peripheral nerves and over-expressed neuroblastoma. associated ≥grade 3 neuropathic pain. Targeting GD2 stimulates the NMDA receptor, makes ketamine useful treatment of The objective this retrospective study to describe use pain uncontrolled by opioids, ketamine's impact on total opioid usage...
ABSTRACT Background Treatments for adolescent and young adult (AYA) patients with mature B‐cell lymphomas (MBCL) differ between versus pediatric centers, data are scarce regarding comparative toxicities outcomes. Procedures We identified AYA (age 12–39) MBCL seen 2011 2021 at an (AC) (PC) tertiary cancer center. Data baseline characteristics, adverse events, long‐term outcomes were collected. Results A total of 173 identified, 20 in the PC 153 AC. During treatment, more unplanned...
ABSTRACT It is unclear if adolescents with sickle cell disease (SCD) are screened for depression, since primary care provider (PCP) visits decline age and socioeconomic disadvantage may impact receipt of care. This 1‐year study identified 97% SCD at Nationwide Children's Hospital (NCH) had a PCP. Among those an NCH PCP ( n = 55), 40% saw their 33% were depression. Socioeconomic was not associated depression screening p 0.55) or 0.22). While often have PCPs, interventions to increase...
ABSTRACT Background Sickle cell disease (SCD) is a chronic illness accounting for 134,000 hospital admissions annually. Youth with SCD and youth autism spectrum disorder (ASD) experience health disparities, yet the hospitalization outcomes of these have not been assessed. This study aimed to (i) determine prevalence ASD selected neurodevelopmental disabilities (NDD) among hospitalized (ii) compare in NDD SCD. Procedure ICD‐10 diagnosis codes were used identify admitted (2–18 year olds) SCD,...
To design and test a metric that reflects the overall quality safety performance of our blood marrow transplant program (BMT) use this to enhance care provided patients. The BMT index (BMTI) aggregates events missed opportunities for best practices into composite score clinical program, irrespective type or patient outcome. We selected 13 domains divided them based on time in continuum. journey has 3 general spheres: (1) pretransplant, (2) admission, (3) posttransplant follow-up long-term...
Abstract Background The combination of vincristine, irinotecan, and temozolomide (VIT) is often used to treat children adolescents with relapsed rhabdomyosarcoma (RMS); however, the outcome these patients has not been previously described. Procedures We sought determine response rate (RR) progression‐free survival (PFS) for RMS treated VIT by retrospective review at five tertiary care hospitals. Prior treatment irinotecan was permitted. Results Among 19 a median age 8 years (range 2–17...
Objective The risk of thrombosis is increased in patients with systemic lupus erythematosus (SLE). Few studies have assessed factors associated within the pediatric SLE (pSLE) population. We sought to better characterize these pSLE using Childhood Arthritis & Rheumatology Research Alliance (CARRA) registry. Methods Within CARRA registry, a history were compared those without. Univariate logistic regression was used calculate odds ratios. A multivariable model conducted that included...