A5018764369- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Advances in Oncology and Radiotherapy
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Testicular diseases and treatments
- Ocular Oncology and Treatments
- Sarcoma Diagnosis and Treatment
- Artificial Intelligence in Healthcare and Education
- Cancer Research and Treatments
- Virus-based gene therapy research
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Meningioma and schwannoma management
- Global Health and Surgery
- Protein Tyrosine Phosphatases
- Genomics and Phylogenetic Studies
- Pancreatic and Hepatic Oncology Research
The University of Texas MD Anderson Cancer Center
2024-2025
Clinical Research Organization
2024
PLC Connections (United States)
2024
Nationwide Children's Hospital
2015-2023
The Ohio State University
2015-2022
Instituto Nacional de Enfermedades Neoplásicas
2021
National Marrow Donor Program
2021
Pediatrics and Genetics
2020
Feinstein Institute for Medical Research
2018
Northwell Health
2018
Outcomes in children and adolescents with recurrent or progressive high-grade glioma are poor, a historical median overall survival of 5.6 months. Pediatric gliomas largely immunologically silent "cold," few tumor-infiltrating lymphocytes. Preclinically, pediatric brain tumors highly sensitive to oncolytic virotherapy genetically engineered herpes simplex virus type 1 (HSV-1) G207, which lacks genes essential for replication normal tissue.
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes current chemoradiotherapy strategies. Our aim was to study the role of targeted inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients V600E–mutated glioma treated across 29 centers multiple countries. RESULTS Sixty-seven were (pediatric low-grade [PLGGs], n = 56; high-grade [PHGGs], 11) for up 5.6 years. Objective responses...
Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use targeted therapy, especially at progression, is increasingly practiced despite paucity data regarding temporal therapy-driven genomic evolution pHGGs. To study the genetic landscape pHGGs recurrence, we performed whole exome methylation analyses on matched primary recurrent...
Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing virotherapy is lack of comprehensive understanding the underlying mechanisms that unfold CNS tumors/associated microenvironments after infusion virus. We demonstrate our multiplex biomarker screening platform comprehensively informs changes both topographical location and functional states resident/infiltrating...
Pediatric cancers typically have a distinct genomic landscape when compared to adult and frequently carry somatic gene fusion events that alter expression drive tumorigenesis. Sensitive specific detection of fusions through the analysis next-generation-based RNA sequencing (RNA-Seq) data is computationally challenging may be confounded by low tumor cellularity or underlying complexity. Furthermore, numerous computational tools are available identify from supporting RNA-Seq reads, yet each...
Meningiomas are a central nervous system tumor primarily afflicting adults, with <1% of cases diagnosed during childhood or adolescence. Somatic variation in NF2 may be found ∼50% meningiomas, other genetic drivers (eg, SMO, AKT1, TRAF7) contributing to wild-type tumors. is an upstream negative regulator YAP signaling and loss the protein product, Merlin, results overexpression target gene transcription. This mechanism dysregulation described NF2-driven but further work necessary understand...
Data on medulloblastoma outcomes and experiences in low- middle-income countries, especially Latin America, is limited. This study examines challenges Mexico's healthcare system, focusing assessing for children with a tertiary care setting.
Germinomas and embryonal carcinomas are central nervous system (CNS) germ cell tumors (GCT) that may overexpress the proto-oncogene c-KIT, a receptor tyrosine kinase, of which dasatinib is potent inhibitor. This retrospective review presents feasibility tolerability administration in select patients with CNS germinoma. Between November 2008 April 2010, six newly diagnosed (n = 3) or recurrent GCT were treated an effort to avoid irradiation and/or delay recurrence. The daily doses...
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare type of brain tumor that affects children and young adults. Molecular prognostic markers PXAs remain poorly established. Similar to gangliogliomas, show prominent immune cell infiltrate, but its composition also remains unknown. In this study, we correlated DNA methylation BRAF status with clinical outcome explored the microenvironment. We performed in 21 samples from 18 subjects histological diagnosis PXA. MethylCIBERSORT was used...
Abstract Recent discoveries have provided valuable insight into the genomic landscape of pediatric low-grade gliomas (LGGs) at diagnosis, facilitating molecularly targeted treatment. However, little is known about their temporal and therapy-related heterogeneity. An adequate understanding evolution LGGs’ profiles over time critically important in guiding decisions therapeutics diagnostic biopsy recurrence. Fluorescence situ hybridization, mutation-specific immunohistochemistry, and/or...
Abstract Primary spinal cord tumors contribute to ≤ 10% of central nervous system in individuals pediatric or adolescent age. Among intramedullary tumors, ependymomas make up ~ 30% this rare tumor population. A twelve-year-old male presented with an intradural, extramedullary mass occupying the dorsal canal from C6 through T2. Gross total resection and histopathology revealed a World Health Organization (WHO) grade 2 ependymoma. He recurred eleven months later extension C2 T1-T2. Subtotal...
Abstract Background Since 2013, pediatric oncologists from Central and South America discuss neuro‐oncology cases with experts North Europe in a web‐based “Latin American Tumor Board” (LATB). Here, we evaluate the feasibility of recommendations rendered by Board. Methods An electronic questionnaire was distributed to physicians who had received between October 2017 2018. Physicians were asked regarding each recommendation given during LATB discussion. Baseline case characteristics all...
Abstract Background: The purpose of this study was to determine the feasibility and tolerability tandem courses high‐dose thiotepa with autologous hematopoietic cell rescue (AHCR) in patients recurrent, refractory solid tumors who were ineligible for a single course therapy due greater than minimal residual disease. Patients decreased hearing or poor renal function eligible. Procedure: Thiotepa administered intravenously at dose 200 mg/m 2 /day (6.67 mg/kg/day) daily 3 days followed by AHCR....
Abstract Background Medulloblastoma is the most common malignant brain tumor in children. While survival has improved high‐income countries (HIC), outcomes for patients low‐to‐middle‐income (LMIC) are unclear. Therefore, we sought to determine of children with medulloblastoma at Instituto Nacional de Enfermedades Neoplasicas (INEN) between 1997 and 2013 Peru. Methods Between 2013, data from 103 older than 3 years were analyzed. Fourteen excluded. The split into two distinct cohorts,...
Abstract Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations RB Transcriptional Corepressor 1 gene, RB1 . Rare cases sellar-suprasellar region retinoblastoma without evidence ocular pineal tumors have been described. A nine-month-old male presented with mass. Histopathology showed an embryonal tumor focal Flexner-Wintersteiner-like rosettes and loss protein (RB1) expression by immunohistochemistry. DNA array-based methylation profiling confidently...
PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and material available Chilean hospitals providing pediatric services. METHODS A cross-sectional survey was distributed to 17 services (Programa Infantil Nacional de Drogas Antineoplásicas [PINDA] hospitals, 11; private, 6). RESULTS Response rate 71% (PINDA, 8; 4). were mainly provided within general (67%). Registries for CNS tumors chemotherapy-related toxicities 100% 67% of respectively. treated by...