A5022971416- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Parvovirus B19 Infection Studies
- CAR-T cell therapy research
- Respiratory viral infections research
- Viral-associated cancers and disorders
- Toxoplasma gondii Research Studies
- Infectious Encephalopathies and Encephalitis
- Influenza Virus Research Studies
- Poxvirus research and outbreaks
- Acne and Rosacea Treatments and Effects
- T-cell and Retrovirus Studies
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Bartonella species infections research
- Autoimmune Neurological Disorders and Treatments
- Neonatal Health and Biochemistry
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Peripheral Neuropathies and Disorders
University of Alabama at Birmingham
2015-2024
Pediatric Infectious Diseases Society
2006-2021
Children's of Alabama
1996-2021
University of Alabama
1998-2020
Medical University of South Carolina
2015
Lucile Packard Children's Hospital
2015
University College London
2015
Johns Hopkins University
1990-2015
Children's National
2015
Children's Hospital of Orange County
2015
The objective of these practice guidelines is to provide clinicians with recommendations for the diagnosis and treatment bacterial meningitis.Patients meningitis are usually treated by primary care emergency medicine physicians at time initial presentation, often in consultation infectious diseases specialists, neurologists, neurosurgeons.In contrast many other diseases, antimicrobial therapy not always based on randomized, prospective, double-blind clinical trials, but rather data initially...
Guidelines for the diagnosis and treatment of patients with encephalitis were prepared by an Expert Panel Infectious Diseases Society America. The guidelines are intended use health care providers who encephalitis. guideline includes data on epidemiology, clinical features, diagnosis, many viral, bacterial, fungal, protozoal, helminthic etiologies provides information when specific etiologic agents should be considered in individual
Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances diagnosis management have been limited, part, by a lack of consensus on case definitions, standardized diagnostic approaches, priorities for research.
We randomly assigned 208 patients who underwent brain biopsy for presumptive herpes simplex encephalitis to receive either vidarabine (15 mg per kilogram of body weight day) or acyclovir (30 10 days. Sixty-nine (33 percent) had biopsy-proved disease; 37 received vidarabine, and 32 acyclovir. The mortality in the recipients was 54 percent, as compared with 28 percent (P = 0.008). Six-month varied according Glasgow coma score at onset therapy. For scores >10, 7 10, ≤6, 42, 46, 67 treated 0,...
Background. Oral oseltamivir administration is effective treatment for influenza in adults. This study was conducted to determine the efficacy, safety and tolerability of children with influenza. Methods. In this randomized, double blind, placebo-controlled study, 1 through 12 years fever [≥100°F (≥38°C)] a history cough or coryza <48 h duration received 2 mg/kg/dose placebo twice daily 5 days. The primary efficacy endpoint time resolution illness including mild/absent mild/absent, return...
The gene designated γ 1 34.5 maps in the inverted repeats flanking long unique sequence of herpes simplex virus-1 (HSV-1) DNA, and therefore it is present two copies per genome. This not essential for viral growth cell culture. Four recombinant viruses were genetically engineered to test function this gene. These (i) a virus from which both deleted, (ii) containing stop codon gene, (iii) after first an insert encoding 16-amino acid epitope known react with specific monoclonal antibody, (iv)...
Original Article from The New England Journal of Medicine — Adenine Arabinoside Therapy Biopsy-Proved Herpes Simplex Encephalitis National Institute Allergy and Infectious Diseases Collaborative Antiviral Study
The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at months, but the benefits wane over time.We conducted a randomized, placebo-controlled trial valganciclovir therapy in neonates CMV disease, comparing months therapy. primary end point was change hearing better ear ("best-ear" hearing) from baseline months. Secondary points included follow-up 12 and 24 neurodevelopmental outcomes, each...
Isolation of herpes simplex virus (HSV) from brain tissue after biopsy has been considered the reference standard for diagnosis encephalitis (HSE). During evaluation antiviral treatment HSE, cerebrospinal fluid (CSF) was obtained patients with clinical disease indicative HSE who underwent diagnostic biopsy. HSV DNA detected by polymerase chain reaction (PCR) in CSF 53 (98%) 54 biopsy-proven and all 18 specimens before proven HSE. Four 19 were positive 2 weeks therapy. Positive results found...
Objective. The objective of this investigation was to establish the safety high-dose (HD) acyclovir for treatment neonatal herpes simplex virus (HSV) disease. In addition, an estimate therapeutic efficacy sought, both with respect mortality and morbidity. Virologic HD also assessed. Participants. Infants who were ≤28 days old whose disease considered be caused by HSV enrolled in study. Patients central nervous system (CNS; N = 28) or disseminated (N 41) infection offered participation trial....
Objective. During the 2 decades in which effective antiviral therapies have been available for neonatal herpes simplex virus (HSV) disease, changes documented not only outcomes of infected infants, but also natural history disease itself. Numerous studies previously reported that early institution therapy is beneficial to outcome disease. The objective this study was provide an update HSV identify means by future improvements management HSV-infected neonates can be made. Design/Methods....
The controlled evaluation of vidarabine as therapy neonatal herpes simplex virus (HSV) infection provided an opportunity to collect data further assess the natural history maternal and newborn infections. Women delivering infected babies were young, nulliparous, infrequent aborters. Nearly 50% gestations ended in premature labor. Maternal was asymptomatic 39 56 (70%) mothers, at time delivery. However, risk factors included a past genital any exposure sexual partner with presumed HSV...
The Food and Drug Administration recently approved the use of palivizumab (pal-vizh-mäb), an intramuscularly administered monoclonal antibody preparation. Recommendations for its are based on a large, randomized study demonstrating 55% reduction in risk hospitalization attributable to respiratory syncytial virus (RSV) infections high-risk pediatric patients. Infants children with chronic lung disease (CLD), formerly designated bronchopulmonary dysplasia, as well prematurely born infants...
In a controlled trial comparing acyclovir with vidarabine in the treatment of neonatal herpes simplex virus (HSV) infection, we found no significant difference between treatments adjusted mortality and morbidity. Hence, sought to define for entire cohort (n = 202) clinical characteristics that best predicted eventual outcome these neonates.
Despite the use of vidarabine, herpes simplex virus (HSV) infection in neonates continues to be a disease high morbidity and mortality. We undertook controlled trial comparing vidarabine with acyclovir for treatment neonatal HSV infection.
Laboratory procedures were compared with brain biopsy findings in 113 biopsy-proven patients herpes simplex virus (HSV) encephalitis and 93 biopsy-negative individuals. Examinations of tissue by histopathology, immunofluorescence, electron microscopy demonstrated evidence HSV infection 56%, 70%, 45% proven cases apparently false-positive results 14%, 9% 2% those biopsy-negative. Serologic assessments revealed that occurred as both a primary (30%) recurrent (70%) infection. Among...