A5019557839- Glioma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neuropharmacology Research
- Photoacoustic and Ultrasonic Imaging
- Neurogenetic and Muscular Disorders Research
- Meningioma and schwannoma management
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- interferon and immune responses
- Thermography and Photoacoustic Techniques
- Muscle Physiology and Disorders
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Amino Acid Enzymes and Metabolism
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Congenital heart defects research
- Traumatic Brain Injury and Neurovascular Disturbances
- Amyotrophic Lateral Sclerosis Research
- Caveolin-1 and cellular processes
University of Alberta
2014-2024
Women and Children’s Health Research Institute
2018-2024
University of Alberta Hospital
2017-2024
Alberta Hospital Edmonton
2017-2024
Stollery Children's Hospital
2019-2024
Cleveland Clinic
2024
University of Bonn
2008-2023
Health Sciences Centre
2020-2021
Princess Margaret Cancer Centre
2016
Hospital for Sick Children
2016
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors a higher mortality rate, while high-grade better outcome. However, we little understanding of their biology therefore cannot explain this nor what constitutes optimal management. Here report comprehensive genetic analysis an international cohort clinically annotated infant gliomas, revealing 3 subgroups. Group 1 arise the cerebral hemispheres harbor alterations receptor tyrosine...
Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a biology natural history. The therapeutic value of cytoreductive surgery radiation therapy for posterior after accounting subgroup is not known.Four independent nonoverlapping retrospective cohorts ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models designed based on known clinical newly described biomarkers identified by multivariable...
The occurrence of neurological symptoms and developmental delay in patients affected by congenital hypothyroidism (CH) has been attributed to the lack thyroid hormone developing CNS. Accordingly, after introduction neonatal screening programs for CH, which allowed early adequate treatment, an almost normal outcome most CH could be achieved. However, a few did not reach this favorable despite treatment. Here we describe five with variable degrees who suffered from choreoathetosis, muscular...
The occurrence of neurological symptoms and developmental delay in patients affected by congenital hypothyroidism (CH) has been attributed to the lack thyroid hormone developing CNS. Accordingly, after introduction neonatal screening programs for CH, which allowed early adequate treatment, an almost normal outcome most CH could be achieved. However, a few did not reach this favorable despite treatment. Here we describe five with variable degrees who suffered from choreoathetosis, muscular...
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes current chemoradiotherapy strategies. Our aim was to study the role of targeted inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients V600E–mutated glioma treated across 29 centers multiple countries. RESULTS Sixty-seven were (pediatric low-grade [PLGGs], n = 56; high-grade [PHGGs], 11) for up 5.6 years. Objective responses...
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
The primary mechanism for eliminating synaptically released glutamate is uptake by astrocytes. In the present study, we examined whether traumatic brain injury (TBI) affects cellular expression of transporters EAAT1 and EAAT2. Morphometrical immunohistochemical analysis demonstrated a predominant EAAT2 in astrocytes normal human neocortex (n = 10). Following 55), number EAAT2-positive cells was decreased prolonged survival period within traumatized pericontusional region. GFAP-positive first...
Abstract Traumatic brain injury is followed by increased extracellular glutamate concentration. Uptake of mainly mediated the glial transporters GLAST and GLT‐1. Extent distribution GLT‐1 were studied in a rat model controlled cortical impact (CCII). Western Blot analysis revealed lowest levels with decrease 40%–54% 42%–49% between 24 72 h posttrauma. By 8 after CCII, CSF (10.5 μM vs. 2.56 controls; P < 0.001), reaching maximum values 48 h. A significant increase de novo expressing...
Abstract Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features atypical teratoid/rhabdoid tumors (ATRT). Rare non‐rhabdoid showing cribriform growth pattern have been designated neuroepithelial (CRINET). Small case series suggest that CRINETs may relatively favorable prognosis. However, the long‐term outcome is unclear it remains uncertain whether CRINET represents distinct entity or variant ATRT. Therefore, 10 were clinically molecularly...
Abstract Histological visualizations are critical to clinical disease management and fundamental biological understanding. However, current approaches that rely on bright-field microscopy require extensive tissue preparation prior imaging. These processes both labor intensive contribute creating significant delays in feedback for treatment decisions can extend 2–3 weeks standard paraffin-embedded interpretation, especially if ancillary testing is needed. Here, we present the first...
Abstract Atypical teratoid/rhabdoid tumor (ATRT) is an aggressive central nervous system characterized by loss of SMARCB1/INI1 protein expression and comprises three distinct molecular groups, ATRT–TYR, ATRT–MYC ATRT–SHH. ATRT–SHH represents the largest group heterogeneous with regard to age, location epigenetic profile. We, therefore, aimed investigate if heterogeneity within might also have biological clinical importance. Consensus clustering DNA methylation profiles confirmatory t-SNE...
Glioblastoma is the most common and aggressive malignant brain tumor in adults, with an increasing incidence a poor prognosis. Current challenges glioblastoma management include rapid growth, limited treatment effectiveness, high recurrence rates, significant impact on patients’ quality of life. Given complexity care recent advancements diagnostic modalities, updated guidelines are needed Canada. This Delphi study aimed to develop Canadian consensus recommendations for diagnosis,...
Abstract Malignant brain tumors are among the deadliest neoplasms with lowest survival rates of any cancer type. In considering surgical tumor resection, suboptimal extent resection is linked to poor clinical outcomes and lower overall rates. Currently available tools for intraoperative histopathological assessment require an average 20 min processing limited diagnostic quality guiding surgeries. Consequently, there unaddressed need a rapid imaging technique guide maximal tumors. Working...
CT7 (MAGE-C1) is a member of the cancer testis (CT) antigen family. The present study describes generation CT7-33, monoclonal antibody (MAb) to CT7, and preliminary protein expression analysis in normal tissues limited number neoplastic lesions. CT7-33 was effective frozen as well formalin-fixed, paraffin-embedded tissues, immunohistochemistry/reverse transcriptase polymerase chain reaction (RT-PCR) co-typing demonstrated specificity. immunoreactivity adult restricted testicular germ cells....