A5004886970- Glioma Diagnosis and Treatment
- Global Health and Surgery
- Cerebrospinal fluid and hydrocephalus
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Spinal Dysraphism and Malformations
- Malaria Research and Control
- Diversity and Career in Medicine
- Meningioma and schwannoma management
- Organ Donation and Transplantation
- Travel-related health issues
- Surgical Simulation and Training
- Medical Imaging and Analysis
- Trauma and Emergency Care Studies
- Palliative Care and End-of-Life Issues
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Fetal and Pediatric Neurological Disorders
- Global Health Workforce Issues
- Artificial Intelligence in Healthcare and Education
- Head and Neck Surgical Oncology
- Zoonotic diseases and public health
- Childhood Cancer Survivors' Quality of Life
- Dementia and Cognitive Impairment Research
- History of Medical Practice
Vanderbilt University Medical Center
2021-2024
Vanderbilt Health
2024
Advisory Board Company (United States)
2024
University of Cape Coast
2023
Neurological Surgery
2022-2023
Minnesota Department of Health
2020
University of Minnesota
2020
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
INTRODUCTION: The management of pediatric hydrocephalus in LMICs is complicated by a heavy burden disease, inadequate surgical infrastructure, and limited exposure to endoscopic treatment, leading non-standardized shunt-related morbidity. METHODS: A brief survey was administered recent graduates the NeuroKids training program. Questions sought understand surgeons’ before after their training. RESULTS: Six fellows from four countries (Egypt (2), Brazil Nigeria, Kenya) participated survey....
Abstract Background Despite improvements in overall survival for pediatric cancers, treatment disparities remain racial/ethnic minorities compared to non‐Hispanic Whites; however, the impact of race on outcomes brain and central nervous system (CNS) tumors United States is not well known. Methods We included 8713 children aged 0‐19 years with newly diagnosed primary CNS between 2000 2015 from Census Tract‐level SES Rurality Database developed by Surveillance, Epidemiology, End Results (SEER)...
OBJECTIVE The aim of this study was to compare clinical and craniometric outcomes patients treated for hydrocephalus following fetal myelomeningocele repair (fMMR) via a ventriculoperitoneal shunt (VPS) or endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC). METHODS This retrospective cohort children who were fMMR VPS ETV without CPC (ETV ± CPC) at Vanderbilt between 2012 2021. primary treatment failure time (TTF). Secondary included changes in metrics...
Background Despite achievements in the reduction of malaria globally, imported cases to United States by returning international travelers continue increase. Immigrants from sub-Saharan Africa (SSA) who then travel back their homelands visit friends and relatives (VFRs) experience a disproportionate burden illness. Various studies have explored barriers prevention among VFRs non-VFRs–travelers same destinations with other purpose for travel–but few employed robust epidemiologic study designs...
Understanding of the epidemiology and biology pediatric CNS tumors has advanced dramatically over last decade; however there remains a discrepancy in understanding epidemiologic data clinical capacity between high- lower-income countries.We collected analyzed hospital-level burden capacity-oriented from neurosurgical oncology units at 7 referral hospitals Sub-Saharan Africa (SSA).A cross sectional epidemiological survey was conducted using REDCap SSA sites, capturing 3-month aggregate for...
Refugees, immigrants and migrants often have barriers to travel medicine. Community Advisory Boards (CAB) are a vital but underutilized tool for understanding meeting healthcare needs challenges, providing communities with voice, finding solutions. The paper discusses malaria prevention community-based participatory research project informed by CAB.
OBJECTIVE Wide disparities in neurosurgical oncology care and treatment outcomes exist globally despite recent improvements diagnostics cancer therapy. To better understand the challenges to low-resource settings, authors collected data on national capacity hospital diagnostic across 7 referral hospitals countries sub-Saharan Africa (SSA). METHODS In April 2023, a 42-item self-administered questionnaire was distributed partner neurosurgeons at centers via REDCap provide country-...
Abstract Pediatric low-grade gliomas (PLGG) have excellent outcomes overall but are a major clinical challenge when disseminated. Diffuse leptomeningeal glioneuronal tumor (DLGNT) is recognised entity both clinically and pathologically, however many disseminated LGG (DLGG) fall outside this diagnosis. To better understand the molecular features of DLGG as well risk factors for dissemination, we assembled an international consortium 30 sites, contributing over 200 patients with annotation,...
Abstract BACKGROUND Wide disparities in neurosurgical-oncologic care and treatment outcomes exists globally despite recent improvements diagnostics cancer therapy. To better understand the challenges to low resource settings, we collected data on national neurosurgery capacity hospital diagnostic across 7 referral hospitals countries Sub-Saharan Africa (SSA). METHODS A 42-item self-administered questionnaire was distributed partner neurosurgeons at sites via REDCap April 2023 provide country...
Abstract Background Africa bears >15% of the global burden neurosurgical disease. Yet to date, still has lowest workforce density globally, and efforts fill this gap by 2030 need be multiplied. Although past decade seen an increase in neurosurgery residency programs continent, it is unclear how these are similar or viable. This study aims highlight current status training as well differences within departments, countries African regions. Methods A literature search using keywords...
INTRODUCTION: Understanding of the epidemiology and biology pediatric central nervous system (CNS) tumors has advanced dramatically over last decade; however there remains a discrepancy in understanding epidemiologic clinical capacity-oriented data between high income low middle- or low-income countries. METHODS: A cross sectional epidemiological survey was conducted to determine incidence, diagnosis, management, follow-up paradigm for CNS using REDCap. The administered neurosurgeons at...
Abstract Objective Persistent hydrocephalus following posterior fossa brain tumor (PFBT) resection is a common cause of morbidity in pediatric patients, for which the optimal treatment debated. The purpose this study was to compare outcomes between VPS and ETV patients with persistent surgical PFBT. Methods A post-hoc analysis performed Hydrocephalus Clinical Research Network (HCRN) prospective observational evaluating patients. Children who experienced secondary PFBT from 2008 2021 were...
Abstract Although most pediatric LGG (PLGG) have excellent long-term survival, there is a subset of cases that disseminate throughout the neuraxis (DLGG) very poor outcomes. The reason for this aggressive behavior unknown but we hypothesize distinct and specific biological mechanisms underlie metastatic ability. methylation-based class diffuse leptomeningeal glioneuronal tumor (DLGNT) characterized by MAPK pathway activating fusions with chromosome 1p loss, 19q and/or 1q gain. However, it...