A5086089590- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Disaster Response and Management
- Nosocomial Infections in ICU
- Global Health Workforce Issues
- COVID-19 and healthcare impacts
- Hemodynamic Monitoring and Therapy
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Diversity and Career in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- COVID-19 epidemiological studies
- Clinical Reasoning and Diagnostic Skills
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Climate Change and Health Impacts
- Healthcare Systems and Public Health
- Cardiac Fibrosis and Remodeling
National Institutes of Health
2023-2025
National Institutes of Health Clinical Center
2020-2025
National Heart Lung and Blood Institute
2023-2025
University of North Carolina at Chapel Hill
2024
University of Toledo
2024
Children's of Alabama
2023
University of Alabama at Birmingham
2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Louisiana State University Health Sciences Center New Orleans
2013-2022
The U.S. antibiotic market failure has threatened future innovation and supply. Understanding when why clinicians underutilize recently approved gram-negative antibiotics might help prioritize the patient in development potential entry rewards.
Importance Little is known about the degree to which suspected sepsis drives broad-spectrum antibiotic use in hospitals, what proportion of courses are unnecessarily broad retrospect, and whether these patterns changing over time. Objective To describe trends empiric for community-onset sepsis. Design, Setting, Participants This cross-sectional study used clinical data from adults admitted 241 US hospitals PINC AI Healthcare Database. Eligible participants were aged 18 years or more between...
OBJECTIVES: To assess the in vitro IntelliSep test, a microfluidic assay that quantifies state of immune activation by evaluating biophysical properties leukocytes, as rapid diagnostic for sepsis. DESIGN: Prospective cohort study. SETTING: Five emergency departments (EDs) Louisiana, Missouri, North Carolina, and Washington. PATIENTS: Adult patients presenting to ED with signs (two four Systemic Inflammatory Response Syndrome criteria, where one must be temperature or WBC count) suspicion...
Abstract Background Newer broad-spectrum beta-lactam antibiotics (cefiderocol, ceftazidime-avibactam, ceftolozane-tazobactam, imipenem-relebactam, meropenem-vaborbactam) have been introduced. Ceftazidime-avibactam and ceftolozane-tazobactam predominated newer antibiotic use through 2021; however, less is known about current patterns for what clinical indications, in inpatient settings. The aim of this study was to describe the these across a large national cohort. Methods We performed...
Abstract Background Guidelines recommend de-escalation of broad-spectrum antibiotics initiated for suspected sepsis based on clinical status and microbiological results after 48-72 hours, yet real world patterns remain unknown. We aimed to evaluate the frequency, hospital-level variation, predictors, outcomes antibiotic in sepsis. Methods used PINC AITM Healthcare Database retrospectively analyze adults admitted 236 US hospitals between 2017-2021 with (blood culture lactate drawn) minimal...
GIM/FP/GP: [Formula: see text] Critical Care: text].
In recent years, new broad-spectrum antibiotics targeting Gram-negative organisms have been introduced, including cefiderocol, ceftazidime-avibactam, ceftolozane-tazobactam, eravacycline, imipenem-relebactam, omadacycline, and meropenem-vaborbactam. This study aimed to describe antibiotic use across a large national cohort. We performed retrospective cohort of hospital discharges from June 2022 May 2023 using the Premier Healthcare Database. Antibiotic utilization was ascertained daily...
Imbalances between hospital caseload and care resources that strained U.S. hospitals during the pandemic have persisted after amid ongoing staff shortages. Understanding which types were more resilient to overcrowding-related excess deaths may prioritize patient safety future crises.
Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients the Southeast region of United States. Multicenter, retrospective cohort including 502 adults with laboratory-confirmed COVID-19 between March 1, 2020, May 8, 2020 within 1 15 participating hospitals 5 health systems across states The study objectives were identify hospital (defined as a composite intensive care unit admission or requirement mechanical ventilation) In...
Sepsis is a common cause of morbidity and mortality. A reliable, rapid, early indicator can help improve efficiency care outcomes. To assess the IntelliSep test, novel in vitro diagnostic that quantifies state immune activation by measuring biophysical properties leukocytes, as rapid for sepsis measure severity illness, defined Sequential Organ Failure Assessment Acute Physiology Chronic Health Evaluation-II scores need hospitalization.Adult patients presenting to two emergency departments...
Cognitive bias is the tendency to subconsciously change ones actions or thought process based on someone else’s comments behavior. It important consider cognitive when performing a usability study because it can significantly alter impair validity of results. While cannot always be entirely eliminated, identifying key biases which results are particularly susceptible first step mitigating them. Once experimenters alert these subtle traps, they approaches that sidestep and greatly improve...
BackgroundDiagnosing meningitis and encephalitis is challenging in the immunosuppressed population. Cerebrospinal fluid (CSF) culture gold standard diagnostic test for cryptococcal (CM), but time intensive requires a high index of suspicion. The BioFire FilmArray Meningitis/Encephalitis (ME) panel offers an option rapid testing. Recent studies suggest similar performance ME compared with CSF initial diagnosis relapse CM. We investigated disease patients presenting meningitis.
Pseudomonas species colonize and infect a broad range of eukaryotic hosts. Infection by these bacteria can significantly impact the diversity composition microbiota produce many natural products, including antibiotics, toxins, signaling molecules. These molecules play essential roles in microbe-microbe microbe-host interactions. This talk describes identification, biosynthesis, activity an unusual copper-containing antibiotic, fluopsin C, produced opportunistic human pathogen aeruginosa. The...
Abdul-Aziz MH, Hammond NE, Brett SJ, et al.