A5039151051- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- Spinal Fractures and Fixation Techniques
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Botulinum Toxin and Related Neurological Disorders
- Vagus Nerve Stimulation Research
- Scoliosis diagnosis and treatment
- Cerebral Palsy and Movement Disorders
- Tuberous Sclerosis Complex Research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Pelvic and Acetabular Injuries
- Neural dynamics and brain function
- Spinal Cord Injury Research
Texas Children's Hospital
2015-2024
Baylor College of Medicine
2015-2024
University of Dayton
2018-2024
Lurie Children's Hospital
2022
University of Louisville
2022
George Mason University
2016
University of Washington
2014
Emory University
2014
University of Chicago
1999-2013
Pediatrics and Genetics
2010
Summary Hypothalamic hamartomas ( HH s) present a difficult medical problem, manifested by gelastic seizures, which are often medically intractable. Although existing techniques offer modest surgical outcomes with the potential for significant morbidity, relatively novel technique of magnetic resonance imaging MRI )–guided stereotactic laser ablation SLA ) offers potentially safer, minimally invasive method high efficacy treatment. We report here on 14 patients refractory epilepsy who...
High-frequency oscillations in local field potentials recorded with intracranial EEG are putative biomarkers of seizure onset zones epileptic brain. However, localized 80-500 Hz can also be from normal and non-epileptic cerebral structures. When defined only by rate or frequency, physiological high-frequency indistinguishable pathological ones, which limit their application epilepsy presurgical planning. We hypothesized that occur a repetitive fashion similar waveform morphology specifically...
The purpose of this study was to prospectively investigate the agreement between epileptogenic zone(s) (EZ) localization by resting-state functional magnetic resonance imaging (rs-fMRI) and seizure onset (SOZ) identified intracranial electroencephalogram (ic-EEG) using novel differentiating ranking criteria rs-fMRI abnormal independent components (ICs) in a large consecutive heterogeneous pediatric intractable epilepsy population without an priori alternate modality informing EZ or prior...
Summary Objective The purpose of this study is to investigate the outcomes epilepsy surgery targeting subcentimeter‐sized resting state functional magnetic resonance imaging (rs‐fMRI) epileptogenic onset zone (EZ) in hypothalamic hamartoma (HH). Methods Fifty‐one children with HH ‐related intractable received anatomical MRI ‐guided stereotactic laser ablation (SLA) procedures. Fifteen these were control subjects ( CS ) not guided by rs‐ fMRI . Thirty‐six had been preoperatively RS determine...
Postoperative resting-state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology is well understood. In sample of who underwent prospective onset zone (SOZ)-targeted surgery, postoperative MRI (rs-fMRI) was performed 6 12 months later. Graded normalization the SOZ compared outcomes, patient, and anatomical characteristics. A total 64 cases were...
Abstract Neuromodulation through implantable pulse generators (IPGs) represents an important treatment approach for neurological disorders. While the field has observed success of state-of-the-art interventions, such as deep brain stimulation (DBS) or responsive neurostimulation (RNS), systems face various technical challenges, including restriction recording from a limited number sites, power management, and external access to assessed neural data in continuous fashion. To best our...
Abstract Exercise may play a role in the prevention of bone fractures postmenopausal osteoporosis. The effects endurance exercise on properties were assessed 9-month-old sham-operated (SH) and ovariectomized (OVX) rats. rats either kept sedentary (SED) or exercised (EX) rodent treadmill at 21 m/minute, 7% grade, 40 minutes/day, 4 days/week for 3 months. Bone mineral (by ash weight), morphometry, biomechanical three-point bending) evaluated after excision bones sacrifice. Ovariectomy resulted...
Neurophysiological monitoring of motor evoked potentials (MEPs) during complex spine procedures may reduce the risk injury by providing feedback to operating surgeon. While this tool is a well-established surgical adjunct in adults, clinical data children are sparse. The purpose study was determine reliability and safety MEP group younger than 3 years age undergoing neurosurgical procedures.A total 10 consecutive spinal (range 5-31 months, mean 16.8 months) were analyzed between January 1,...
Abstract BACKGROUND Hypothalamic hamartomas (HH) are a challenging pathology that cause gelastic seizures. Magnetic Resonance Imaging-guided Laser Interstitial Thermal Therapy (MRgLITT) offers safe and effective treatment for HHs via minimally invasive technique. OBJECTIVE To determine how clinical outcome correlates to residual tumor volume surgical strategy by analyzing radiographic data reconstructing volumetric imaging. METHODS Clinical information of 58 pediatric patients who underwent...
OBJECTIVE Responsive neurostimulation (RNS) is a US FDA-approved form of neuromodulation to treat patients with focal-onset drug-resistant epilepsy (DRE) who are ineligible for or whose condition refractory resection. However, the FDA approval only extends use in one two epileptogenic foci. Recent literature has shown possible efficacy thalamic RNS Lennox-Gastaut syndrome and multifocal epilepsy. The authors hypothesized that nuclei may be effective seizure reduction regionalized-onset DRE....
INTRODUCTION: Glioblastoma multiforme is the most common primary intracranial malignant brain tumor in adults, known for its aggressive behavior and poor prognosis. Several therapeutic approaches have been described; unfortunately, no treatment alternatives substantially impacted disease course. Gene therapy promises ability to deliver specific sequences into certain cells, but we still lack target tumoral cell types human brain. METHODS: To develop selective AAV gene vectors, adapted an...
INTRODUCTION: Gene therapy promises to improve outcomes for our most frustrating pathologies. To date, however, we have no method deliver such sequence-based therapies selectively into the cell types involved. Virtually all prior work on adeno-associated viruses, common vector neurological gene therapies, has studied capsid tropism in model organisms, primarily mice, despite abundant data showing poor translation across species. METHODS: Patients undergoing neurosurgical procedures are...
Object. Interest has developed in the use of magnesium (Mg ++ ) as a neuroprotectant and antivasospastic agent. Magnesium may increase cerebral blood flow (CBF) reduce contraction arteries caused by various stimuli. In this study authors tested hypothesis that continuous intravenous infusion Mg reduces vasospasm after experimental subarachnoid hemorrhage (SAH). Methods. A dose-finding was conducted five monkeys (Macaca fascicularis) to determine what doses MgSO 4 elevate cerebrospinal fluid...
OBJECTIVE The management of upper cervical spinal instability in children continues to represent a technical challenge. Traditionally, number wiring techniques followed by halo orthosis have been applied; however, they associated with high rate nonunion and poor tolerance for the halo. Alternatively, C1–C2 transarticular screws C2 pars/pedicle allow more rigid fixation, but are technically demanding vertebral artery injuries. Recently, translaminar added armamentarium pediatric spine surgeon...
Object National and international meetings, such as the Congress of Neurological Surgeons (CNS) American Association (AANS) provide a central location for gathering dissemination research. The purpose this study was to determine publication rates both oral poster presentations at CNS AANS meetings in peer-reviewed journals. Methods authors reviewed all accepted abstracts, presented either or presentations, from 2003 2005. This information then used search PubMed rate abstracts meetings....
The absence of surgical subspecialty emergency care in the United States is a growing public health concern. Neurosurgery field lacking coverage many areas country; however, this generally thought to be greater concern rural areas. Because decreasing numbers neurosurgeons, medical malpractice, and liability concerns, neurosurgery becoming crisis urban Our objective was quantify neurosurgical transfers academic centers Cook County, IL, including patient demographics, reasons for transfer,...