A5067809925- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Cleft Lip and Palate Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Craniofacial Disorders and Treatments
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Pharmacological Effects and Toxicity Studies
- Photoreceptor and optogenetics research
- Carcinogens and Genotoxicity Assessment
- Glioma Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Neural dynamics and brain function
- Genomics and Rare Diseases
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- History of Medical Practice
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Sleep and Wakefulness Research
- Global Health and Surgery
- Telemedicine and Telehealth Implementation
- Spinal Dysraphism and Malformations
- Neurological and metabolic disorders
- Infectious Encephalopathies and Encephalitis
Children's Hospital Colorado
2019-2025
University of Colorado Denver
2017-2025
University of Colorado Anschutz Medical Campus
2019-2025
University of Colorado System
2024
University of Colorado Colorado Springs
2023
Creative Commons
2023
S.P.E.C.I.E.S.
2019
Center for Children
2019
Stanford University
2011-2017
Krasnoyarsk State Medical University
2011
Abstract Post-zygotically acquired genetic variants, or somatic that arise during cortical development have emerged as important causes of focal epilepsies, particularly those due to malformations development. Pathogenic variants been identified in many genes within the PI3K-AKT-mTOR-signalling pathway individuals with hemimegalencephaly and dysplasia (type II), more recently SLC35A2 I) non-dysplastic epileptic cortex. Given expanding role across different brain malformations, we sought...
Abstract Neuromodulation via Responsive Neurostimulation (RNS) or Deep Brain Stimulation (DBS) is an emerging treatment strategy for pediatric drug‐resistant epilepsy (DRE). Knowledge gaps exist in patient selection, surgical technique, and perioperative care. Here, we use expert survey to clarify practices. Thirty‐two members of the Pediatric Epilepsy Research Consortium were surveyed using REDCap. Respondents from 17 centers (missing data one): Four implant RNS only while 13 both DBS....
Abstract BACKGROUND Despite the well-documented utility of responsive neurostimulation (RNS, NeuroPace) in adult epilepsy patients, literature on use RNS children is limited. OBJECTIVE To determine real-world efficacy and safety pediatric patients. METHODS Patients with childhood-onset drug-resistant treated were retrospectively identified at 5 centers. Reduction disabling seizures complications evaluated for (<18 yr) young adults (>18 compared prior pertaining to RESULTS Of 35...
In the not too distant future, humankind will embark on one of its greatest adventures, travel to planets. However, deep space is associated with an inevitable exposure radiation fields. Space-relevant doses protons elicit persistent disruptions in cognition and neuronal structure. whether space-relevant irradiation alters neurotransmission unknown. Within hippocampus, a brain region crucial for cognition, perisomatic inhibitory control pyramidal cells (PCs) supplied by two distinct cell...
Epilepsy is common, occurring in 0.5-1.5% of the pediatric US population, with drug-resistant epilepsy (DRE) nearly one-third persons under 18 years age.1,2,3,50 The International League Against (ILAE) defines DRE as "failure adequate trials two tolerated, appropriately chosen and used, antiepileptic drug schedules to achieve sustained seizure freedom".4 After anti-seizure medications (ASMs) have failed, likelihood that an additional ASM will lead freedom around 4-5%.
OBJECTIVE Patients with a history of surgery for single-suture craniosynostosis (SSC) as an infant often wish to participate in sports later childhood. However, there are no established guidelines from neurosurgeons and craniofacial surgeons guide parents which their child should or not participate. Therefore, this study aimed evaluate the attitudes practice patterns experienced regarding counseling caregivers these patients about participation. METHODS A survey was administered plastic...
INTRODUCTION: Epilepsy affects up to 0.5% of children, with one-third considered for surgery due medical refractoriness. Studies show offers better seizure freedom drug-resistant epilepsy than therapy. However, it is underutilized potential complications and postoperative deficits, which have improved over time. This study evaluates the indications MRgLITT compared resective procedures assesses perioperative variables, including outcomes, in pediatric patients undergoing MRgLITT. We report...
Despite the clinical importance of identifying increased intracranial pressure (IIP) in children with craniosynostosis (CS), its presence is often uncertain due to limited utilization invasive measurement methods, inconclusive evaluations, and variability depending on CS phenotype. Hence, prevalence reports are highly variable. We previously developed a computational method identify pediatric chronic IIP diverse etiology based subtle cranial thickness density anomalies quantified from...
Childhood epilepsy is a common and devastating condition, for which many children still do not have adequate treatment. Some with drug-resistant require surgical excision of epileptogenic brain tissue seizure control, affording the opportunity to study this ex vivo interrogate human epileptic neurons potentially hyperexcitable perturbations in intrinsic electrophysiological properties. In study, we characterized diversity layer L2/3 (L2/3) pyramidal (PNs) slices from pediatric patients...
Drug-resistant epilepsy (DRE) occurs at higher rates in children <3 years old. Epilepsy surgery is effective, but rarely utilized young despite developmental benefits of early seizure freedom. The present study aims to identify unique patient characteristics and evaluation strategies old who undergo as a means assess contributors potential solutions health care disparities this group.The Pediatric Research Consortium Surgery Database, multicentered, cross-sectional collaboration 21 US...
Abstract Objectives Corpus callosotomy (CC) is used to reduce seizures, primarily in patients with generalized drug‐resistant epilepsy (DRE). The invasive nature of the procedure contributes underutilization despite its potential superiority other palliative procedures. goal this study was use a multi‐institutional surgery database characterize CC across participating centers. Methods Data were acquired from Pediatric Epilepsy Research Consortium (PERC) Surgery Database, prospective...
The unpredictability and severity of seizures contribute to the debilitating nature epilepsy. These factors also render condition particularly challenging treat, as an ideal treatment would need detect halt pathological bursts hyperactivity without disrupting normal brain activity. Optogenetic techniques offer promising tools study perhaps eventually treat this episodic disorder by controlling specific circuits in epileptic animals with great temporal precision. Here, we briefly review...
BACKGROUND Pediatric cervical spine injuries (CSI) are rare but potentially devastating sequelae of blunt trauma. Existing protocols to evaluate children at risk for CSI frequently incorporate computed topography (CT) and magnetic resonance imaging (MRI); however, the clinical value performing both remains unclear. METHODS Single-center retrospective review pediatric trauma patients who underwent CT MRI between 2001 2015. Based on radiographic findings, results were grouped into one three...
Stereotactic electroencephalography (SEEG) is an increasingly common technique that neurosurgeons use to help identify the epileptogenic zone. The anchor bolt, which typically secures electrode skull, can be problematic in very thin bone or electrodes placed occiput.
Fragile X Syndrome (FXS) is a neurodevelopmental disorder instigated by the absence of key translation regulating protein, Mental Retardation Protein (FMRP). The loss FMRP in CNS leads to abnormal synaptic development, disruption critical periods plasticity, and an overall deficiency proper sensory circuit coding leading hyperexcitable networks. However, little known about how this environment affects inhibitory plasticity. Here, we show that vivo layer 2/3 primary somatosensory cortex Fmr1...
Temporal lobe epilepsy (TLE) is often associated with memory deficits. Reactivation of traces in the hippocampus occurs during sharp-wave ripples (SWRs; 140-250 Hz). To better understand mechanisms underlying high-frequency oscillations and cognitive comorbidities epilepsy, we evaluated how rigorously identified deep CA1 pyramidal cells (dPCs) discharge SWRs control TLE mice.We used unilateral intraamygdala kainate model video-electroencephalography (EEG) verified chronically epileptic adult...