A5037185693- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Head and Neck Surgical Oncology
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neurological disorders and treatments
- Bacterial Infections and Vaccines
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Cardiac Arrhythmias and Treatments
- Anesthesia and Pain Management
- Spinal Dysraphism and Malformations
- Congenital Heart Disease Studies
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Parkinson's Disease Mechanisms and Treatments
- Pain Management and Treatment
- Cervical and Thoracic Myelopathy
- Lysosomal Storage Disorders Research
- Mosquito-borne diseases and control
Columbia University Irving Medical Center
2024-2025
Phoenix Children's Hospital
2022-2024
Henry Ford Health System
2013-2024
Barrow Neurological Institute
2022-2024
Morgan Stanley Children's Hospital
2024
Penn Presbyterian Medical Center
2024
Henry Ford Hospital
2018-2023
Neurological Surgery
2021-2022
Sunnybrook Health Science Centre
2018
University of Toronto
2018
Abstract BACKGROUND Despite the well-documented utility of responsive neurostimulation (RNS, NeuroPace) in adult epilepsy patients, literature on use RNS children is limited. OBJECTIVE To determine real-world efficacy and safety pediatric patients. METHODS Patients with childhood-onset drug-resistant treated were retrospectively identified at 5 centers. Reduction disabling seizures complications evaluated for (<18 yr) young adults (>18 compared prior pertaining to RESULTS Of 35...
Neurogenesis is associated with functional recovery after stroke. However, the underlying molecular mechanisms have not been fully investigated. Using an Ago2-based RNA immunoprecipitation to immunoprecipated Ago2-RNA complexes followed by sequencing (Ago2 RIP-seq) approach, we profiled miRNomes in neural progenitor cells (NPCs) harvested from subventricular zone (SVZ) of lateral ventricles young adult rats. We identified more than 7 and 15 million reads normal ischemic NPC libraries,...
Background The effect of time and temperature on beta‐2 transferrin stability in cerebrospinal fluid (CSF) is not well established. After collecting nasal CSF for testing, has been found to be stable detectable 1 week, whether being refrigerated or stored at room temperature. purpose this study was determine if remained longer than week refrigeration improved its detectability. Methods In patients undergoing therapeutic diversion, 2‐mL samples were collected from 18 patients. divided either...
The aim of this study is to describe the management and evolution a patient with rare condition double lactotroph tumors assess role intraoperative ultrasonography (IOUS) for their detection methylation-based liquid biopsy diagnosis monitoring. A 29-year-old woman diagnosed through hormonal MRI workup underwent surgical resection due cabergoline intolerance. To detect tumor missing visual inspection, IOUS was performed. Pituitary (PT) nontumor (NT) tissues blood were collected pathological...
Since there is no cure for glioblastoma multiforme (GBM), the goal of treatment becomes prolonging survival through cytoreduction while minimising neurological deficits. In this case report, laser interstitial thermal therapy (LITT) was used once tumour progressed into isthmus cingulate gyrus. One year after temporal lobectomy, disorders memory, emotion, personality and navigation, likely related to limbic system involvement along with hallucinations fluctuating cognition occurred as...
Case: Spinal deformity associated with Guillain-Barre syndrome (GBS) is not commonly reported. We present a 6-year-old girl who developed kyphoscoliosis after being diagnosed GBS. She had extensive motor deficits requiring 2 hospitalizations and treatment IV immunoglobulin therapy. Five months diagnosis, she presented to our clinic 15° coronal scoliosis 65° thoracic kyphosis. At 6-month follow-up, kyphosis progressed 77° no significant change in the curve. 1 year, sagittal alignment was...
Background: An accurate knowledge of a patient’s risk cord-level intraoperative neuromonitoring (IONM) data loss is important for an informed decision-making process prior to deformity correction, but no prediction tool currently exists. Methods: A total 1,106 patients with spinal and 205 perioperative variables were included. stepwise machine-learning (ML) approach using random forest (RF) analysis multivariable logistic regression was performed. Patients randomly allocated training (75%...
First reported in 1988, Staphylococcus lugdunensis is a virulent coagulase-negative species often associated with endocarditis. This the first case report describing this infection cervical spine. A 58-year-old, left-handed Caucasian woman no significant medical history presented neck and left arm pain. Neurological examination revealed mild deltoid 4/5 weakness myelopathy. She was found to have an epidural spinal cord mass that causing severe compression underwent partial anterior...
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is an incompletely defined disease process with no known unifying pathophysiological mechanism. OBJECTIVE: To our knowledge, genetic studies have been performed in a North American population. summarize findings from previous and to comprehensively test for these associations novel diverse, multi-institutional METHODS: Cross-sectional, single nucleotide polymorphism (SNP) analysis was 55 of 121 enrolled patients DISH. Baseline...
SUMMARY The majority of Plasmodium falciparum field isolates are defined as complex infections because they contain multiple genetically distinct clones. Studying interactions between clones in vivo and vitro could elucidate important phenomena malaria infection, transmission treatment. Using quantitative PCR (qPCR) the P. merozoite surface protein 1, block 2 ( Pf MSP1-B2), we provide a sensitive efficient genotyping method. This is for epidemiological studies it makes possible to study...
Ventriculoatrial (VA) shunt disconnection can result in distal catheter migration into the cardiopulmonary vasculature. There is little guidance current literature on how to prevent and manage this uncommon yet potentially serious complication. The authors reviewed existing described three instances of VA shunts offered insight methods mitigate such complications.Eighteen patients were identified with shunts. Of these patients, seven as having a connector neck, which associated migration. In...
Hypertrophic olivary degeneration (HOD) is a rare condition that can occur after disruption of the Guillain-Mollaret triangle. Clinically, HOD present with palatal myoclonus or without oculopalatal tremor, which sometimes results in symptomatic dysphagia and/or speech abnormalities. This commonly associated vascular lesions, only three prior reported cases resulting from intracranial abscess.An otherwise healthy patient developed multiple abscesses. Biopsy showed gram-positive cocci;...
Abstract BACKGROUND New techniques of intraoperative magnetic resonance imaging (MRI)-guided stereotaxy enable minimally invasive approaches to intracranial pathology. Laser interstitial thermal therapy (LITT), convection-enhanced drug delivery, and stereotactic biopsy can be performed with a real-time confirmation location the ability adjust for shift during procedure. However, these procedures are constrained by patient positioning need trajectories that avoid collision between elements...
Zervos, Thomas MD; Bazydlo, Michael MS; Tundo, Kelly BS; Macki, Mohamed Rock, Jack P MD Author Information