A5016774697- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Pharmacological Effects and Toxicity Studies
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Tuberous Sclerosis Complex Research
- Moyamoya disease diagnosis and treatment
- Neuroblastoma Research and Treatments
- Genetic and Kidney Cyst Diseases
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Craniofacial Disorders and Treatments
- Neonatal and fetal brain pathology
- Botulinum Toxin and Related Neurological Disorders
University of Utah
2016-2025
Primary Children's Hospital
2016-2025
Neurological Surgery
2021
University of Michigan
2021
Michigan Medicine
2021
University of Toronto
2019
Hospital for Sick Children
2019
SickKids Foundation
2019
Duke University Hospital
2019
Duke Medical Center
2019
Chiari malformation Type I (CM-I) is a congenital anomaly often treated by decompressive surgery. Patients who fail to respond standard surgical management have complex anomalies of the craniovertebral junction and brainstem compression, requiring reduction occipitocervical fusion. The authors hypothesized that subgroup "complex" patients defined specific radiographic risk factors may higher rate fusion.A retrospective review was conducted clinical data in pediatric undergoing surgery for...
Abstract “Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” is a recently described tumor entity of the central nervous system with predilection for origin in septum pellucidum and defining dinucleotide mutation at codon 385 oncogene replacing lysine either leucine or isoleucine (p.K385L/I). Clinical outcomes optimal treatment this new have yet to be defined. Here, we report comprehensive clinical, radiologic, histopathologic assessment eight cases. In addition its stereotypic location...
Abstract BACKGROUND Despite the well-documented utility of responsive neurostimulation (RNS, NeuroPace) in adult epilepsy patients, literature on use RNS children is limited. OBJECTIVE To determine real-world efficacy and safety pediatric patients. METHODS Patients with childhood-onset drug-resistant treated were retrospectively identified at 5 centers. Reduction disabling seizures complications evaluated for (<18 yr) young adults (>18 compared prior pertaining to RESULTS Of 35...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
We evaluate the effects of adjuvant treatment with angiogenesis inhibitor Avastin (bevacizumab) on pathological tissue specimens high-grade glioma. Tissue from five patients before and after was subjected to histological evaluation compared four control cases glioma similar protocols not including bevacizumab. Clinical radiographic data were reviewed. Histological analysis focused microvessel density vascular morphology, expression patterns endothelial growth factor-A (VEGF-A) hematopoietic...
Summary Objective Drug‐resistant epilepsy (DRE) during the first few months of life is challenging and necessitates aggressive treatment, including surgery. Because most common causes DRE in infancy are related to extensive developmental anomalies, surgery often entails tissue resections or disconnection. The literature on “ultra‐early” sparse, with limited data concerning efficacy controlling seizures, safety. current study's goal review safety ultra‐early performed before age 3 months....
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
Anterior two-thirds corpus callosotomy is a common palliative surgical intervention most commonly employed in patients with atonic or drop seizures. Recently, stereotactic laser ablation of the callosum without craniotomy has shown promise achieving similar outcomes fewer side effects and shorter hospitalizations. The authors demonstrate anterior patient Lennox-Gastaut syndrome drug-resistant Technical nuances 3 fibers are described. Postoperatively, showed significant reduction seizure...
Risk factors for blunt cerebrovascular injury (BCVI) may differ between children and adults, suggesting that at low risk BCVI after trauma receive unnecessary computed tomography angiography (CTA) high-dose radiation. We previously developed a score predicting pediatric based on retrospective cohort analysis. Our objective is to externally validate this prediction with multi-institutional cohort. included patients who underwent CTA traumatic cranial four Level I centers. Each patient in the...
Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in pediatric population, there is a large variability seizure outcomes at group level. A recently developed HOPS score provides individualized estimation of likelihood freedom to complement clinical judgement. The objective this study was develop freely accessible online calculator that accurately predicts probability any patient 1-, 2-, and 5-years post-hemispherectomy. Retrospective...
BACKGROUND Hamartomas of the floor fourth ventricle (HFFVs) are rare lesions that cause a variety symptoms, including hemifacial spasm (HFS). When symptomatic, these deep-seated traditionally treated via open surgical approaches. The authors describe successful laser interstitial thermal therapy (LITT) an HFFV causing intractable HFS. OBSERVATIONS A healthy 19-month-old girl presented with right HFS, present since birth, occurring continuously throughout day. MRI revealed HFFV. Following...
INTRODUCTION: Brain arteriovenous malformations (AVMs) are the leading cause of spontaneous intracranial hemorrhage in children, and AVM rupture can lead to significant morbidity mortality. Understanding angioarchitectural features associated with is critical guide management strategies improve outcomes. METHODS: We retrospectively reviewed records 63 pediatric patients who underwent surgical resection for AVMs at our institution between 1998 2023. Demographic factors, clinical presentation,...
Object In this paper the authors' goal was to identify preoperative variables that predict long-term seizure freedom among patients with mesial temporal sclerosis (MTS) after single-stage anterior lobectomy and amygdalohippocampectomy (ATL-AH). Methods The authors retrospectively reviewed 116 consecutive (66 females, mean age at surgery 40.7 years) refractory seizures pathologically confirmed MTS who underwent ATL-AH least 2 years of follow-up. All MRI video-electroencephalography (EEG); 106...
OBJECT Computed tomography angiography (CTA) is frequently used to examine patients for blunt cerebrovascular injury (BCVI) after cranial trauma, but the pediatric population at risk BCVI poorly defined. Although CTA effective screening in adults, increased lifetime malignant tumors associated with this modality warrants efforts reduce its use children. The authors' objective was evaluate incidence of diagnosed by a patient cohort and create prediction model identify children high BCVI....
Currarino syndrome is a rare constellation of congenital anomalies characterized by the triad sacral dysgenesis, presacral mass, and anorectal malformation. It frequently associated with other anomalies, often including occult spinal dysraphism. Mutations in MNX1 gene are identified majority cases. The authors report case an infant tethered cord dorsal lipomyelomeningocele continuous intradural lipoma, addition to imperforate anus scimitar sacrum. They review literature highlight patterns...
Large experiences with the treatment of pediatric arteriovenous malformations (AVMs) remain relatively rare, limited data on presentation, treatment, and long-term functional outcomes. Because expected long lifespan children, caregivers are especially interested in outcome measures that assess quality life. The authors' intention was to describe outcomes patients who undergo AVM surgery identify predictors sustained neurological deficits.
Cranial osteosarcoma is very rare in children, rendering the development of optimal treatment algorithms challenging. The authors present 3 cases pediatric cranial osteosarcoma: a primary calvarial tumor, metastasis, and base. A review literature demonstrates significant variation management osteosarcomas outcome for patients with these tumors. This series presented to improve understanding reinforce importance maximal resection optimizing outcome.
Objective assessment of head shape has been an elusive goal in the management craniosynostosis patients. Clinical judgment, craniometric indices, and computed tomography scans are primary means through which a surgeon assesses this patient population. The purpose study was to examine discuss utility STARscanner for evaluation surgical outcomes metopic synostosis A retrospective chart review patients with who underwent fronto-orbital advancement pre- postoperative imaging at Texas Children's...
OBJECTIVE Intrathecal baclofen infusion systems to manage severe spasticity and dystonia are associated with higher infection rates in children than adults. Factors unique this population, such as poor nutrition physical limitations for pump placement, have been hypothesized the reasons disparity. The authors assessed potential risk factors a multivariate analysis. METHODS Patients who underwent implantation of programmable intrathecal catheter at single center between January 1, 2000, March...
The authors report the case of a previously healthy 6-month-old girl who presented with right arm and leg stiffening consistent seizure activity. An initial CT scan head demonstrated acute subarachnoid hemorrhage in basal cisterns extending into left sylvian fissure. Computed tomography angiography 7 × 6 5–mm saccular aneurysm inferior M 2 division middle cerebral artery. patient underwent craniotomy microsurgical clip ligation wrapping neck because vessel appeared circumferentially...