A5102990667- Glioma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Diversity and Career in Medicine
- Cancer Treatment and Pharmacology
- Skin Protection and Aging
- Cancer, Hypoxia, and Metabolism
- Medicine and Dermatology Studies History
- melanin and skin pigmentation
- Meningioma and schwannoma management
- Innovations in Medical Education
- Autoimmune Bullous Skin Diseases
- Dental Education, Practice, Research
- Autoimmune and Inflammatory Disorders
- Parkinson's Disease Mechanisms and Treatments
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Skin and Cellular Biology Research
- Nanoparticle-Based Drug Delivery
- Inflammatory Myopathies and Dermatomyositis
- Dermatological diseases and infestations
- Hidradenitis Suppurativa and Treatments
- Peripheral Nerve Disorders
University of Oklahoma Health Sciences Center
2018-2023
University of Oklahoma
2020-2021
Polyclinic Medical Center
2021
Oklahoma State University Oklahoma City
2018-2020
Johns Hopkins Medicine
2014-2018
OU Health Stephenson Cancer Center
2018
Johns Hopkins University
2014-2018
UCLA Health
2017
The Royal Melbourne Hospital
2015
Johns Hopkins Hospital
2015
In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to able respond needs payers and credentialing licensure bodies demonstrate dermatologic value.OBJECTIVE To examine feasibility using Physician Global Assessment (PGA) scores collect track patient acne psoriasis outcomes over time. DESIGN, SETTING, AND PARTICIPANTSThe PGA severity were included on physicians' billing sheets for patients with seen at tertiary care...
Abstract “Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” is a recently described tumor entity of the central nervous system with predilection for origin in septum pellucidum and defining dinucleotide mutation at codon 385 oncogene replacing lysine either leucine or isoleucine (p.K385L/I). Clinical outcomes optimal treatment this new have yet to be defined. Here, we report comprehensive clinical, radiologic, histopathologic assessment eight cases. In addition its stereotypic location...
Periocular dark circles (PDCs) are a common cosmetic complaint. Grading systems based on objective measures have been used but no standard system is in place.To determine factors associated with subjective and PDC severity.Enrolled patients (n=100) completed questionnaire comprised of demographic variables, medical history, self-perception PDC. Those perceiving graded dissatisfaction 10-point scale. Clinical severity (grades 0~4) subtype (constitutional, post-inflammatory, vascular, shadow...
Background: The pathophysiology of multiple sclerosis (MS) tremor is uncertain with limited phenotypical studies available. Objective: To investigate whether dystonia contributes to MS and its severity. Methods: patients ( n = 54) without disabling uni- or bilateral upper limb were recruited (39 limbs per group). We rated severity, writing Archimedes spiral drawing; cerebellar dysfunction (SARA score); the Global Dystonia Scale (GDS) for proximal distal limbs, dystonic posturing, mirror...
Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on acquired form that presents adulthood. Unlike its counterpart, AE (AAE) often underlying pathologic or iatrogenic etiologies interfere with nutritional absorption, such inflammatory bowel alcoholism. Various gastrointestinal pathologies associated AAE, but there currently no report...
2538 Background: Despite therapeutic advances, the median overall survival for patients with recurrent, high-grade gliomas remains poor. Thus, there is an urgent need efficacious new therapies. The nitrone compound, OKN-007 (disodium 4-[(tert-butyl-imino) methyl] benzene-1,3-disulfonate N-oxide) a promising novel anti-cancer agent. In orthotopic glioblastoma xenografts, reduces cell proliferation and angiogenesis, increases apoptosis. Here we report on safety, efficacy, pharmacokinetics (PK)...
A positive correlation between leadership roles and job satisfaction has been noted in some areas of business. Since senior leaders academic dermatology appear to be more satisfied than their junior colleagues, a similar relationship may important dermatology.To determine if there is an association career dermatologists.A cross-sectional, anonymous survey was mailed 1263 dermatologists across the US. Participants were questioned on demographics satisfaction. Academic rank position compared...
<h3>Objective:</h3> Immune checkpoint inhibitors (ICI), such as cytotoxic lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1)/programmed death-ligand (PD-L1) axis are treatment for several malignancies. Myasthenia gravis (MG) is a rare but life-threatening adverse event of ICI. <h3>Background:</h3> With ICI single agent use, 42 cases new-onset MG reported in literature, among those, 14 patients developed severe respiratory failure required intubation whereas 10 died....
MYC is a central driver of tumorigenesis in many malignancies, including the universally lethal glioblastoma (GBM). However, developing direct inhibitors have proven challenging. One appealing alternative strategy to target MYC-driven cancers interfere with signaling program necessary facilitate MYC-dependent transcription. Cyclin-dependent kinase 9 (CDK9) has emerged as an attractive candidate through its function critical regulator transcriptional elongation and genes. Using panel...
Objective: NA Background: Capecitabine (Xeloda), a 5-Fluoruracil (5-FU) pro-drug, is chemotherapy commonly used in the treatment of breast, colorectal and pancreatic cancers. A limited number case reports exist describing multifocal leukoencephalopathy resulting from capecitabine toxicity. The clinical manifestations, which can range nausea vomiting to seizures coma, are known occur as early 3–7 days following drug initiation or late 1–2 months later. Diagnosis based on characteristic MRI...
Patients with Homologous Recombination Deficits (HRD) have shown increased survival in many cancers. With PARP inhibitors surfacing as a potential therapy for Glioma patients, we aim to explore the existence of HRD and its prognostic value High-Grade patients. We conducted chart review patients Gliomas who received Foundation One testing at The University Oklahoma from 2013 2018. used Ones Loss Heterozygosity (LOH) score measure HRD. analyzed correlation between mutated IDH LOH score. then...
Abstract BACKGROUND Temozolomide (TMZ) with concurrent radiation is the traditional standard of care for newly diagnosed glioblastoma. Unfortunately, this combination has limited efficacy and resistance can render TMZ ineffective. The novel anti-cancer agent OKN-007 plus increased survival in preclinical studies. Therefore, we initiated a phase Ib/feasibility clinical trial (NCT03587038) therapy (RT). We report safety tolerability findings in-progress. METHODS Adults newly-diagnosed GBM were...
Abstract BACKGROUND Temozolomide (TMZ) is the standard of care chemotherapy agent for glioblastoma. Unfortunately, intrinsic or acquired resistance eventually renders TMZ ineffective. The novel anti-cancer OKN-007 plus increased survival in glioma-bearing mice compared to alone. Furthermore, sensitivity both TMZ-sensitive and TMZ-resistant cell lines. Therefore, we initiated a clinical trial (NCT03587038) combination with radiation therapy (RT). Here report safety tolerability findings this...