A5051115405- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Molecular Communication and Nanonetworks
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Agriculture Sustainability and Environmental Impact
Stanford University
2016-2020
University of California, Irvine
2015-2016
California Institute of Technology
2007
A way to prevent generalized seizures? Temporal lobe epilepsy is the most common form of in adults. Patients have spontaneous seizures and risk developing serious cognitive impairment. Bui et al. studied an animal model temporal (see Perspective by Scharfman). Selective optogenetic inhibition dentate gyrus mossy cells increased likelihood electrographic generalizing full behavioral convulsive seizures. Activation reduced likelihood. Thus, activity might serve inhibit seizure propagation....
Abstract Objective To determine if closed‐loop optogenetic seizure intervention, previously shown to reduce duration in a well‐established mouse model chronic temporal lobe epilepsy (TLE), also improves the associated comorbidity of impaired spatial memory. Methods Mice with chronic, spontaneous seizures unilateral intrahippocampal kainic acid TLE, expressing channelrhodopsin parvalbumin‐expressing interneurons, were implanted optical fibers and electrodes, tested for response light...
Abstract Molecular changes that underlie evolutionary in behavior and physiology are not well understood. Dauer formation Caenorhabditis elegans is a temperature-sensitive process controlled through network of signaling pathways associated with sensory neurons potentially an excellent system which to investigate molecular neuronal function during evolution. To begin the evolution dauer genus at level, we isolated dauer-formation mutations C. briggsae, species closely related model organism...