A5018344254- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Spine and Intervertebral Disc Pathology
- Neonatal Respiratory Health Research
- Head and Neck Surgical Oncology
- Nerve Injury and Rehabilitation
- Neurosurgical Procedures and Complications
- Craniofacial Disorders and Treatments
- Advanced MRI Techniques and Applications
- Cleft Lip and Palate Research
- Spinal Fractures and Fixation Techniques
- History of Medical Practice
- RNA modifications and cancer
- Genomics and Rare Diseases
- Cancer, Hypoxia, and Metabolism
The Ohio State University
2017-2025
Nationwide Children's Hospital
2016-2025
Neurological Surgery
2016-2024
The Ohio State University Wexner Medical Center
2016-2024
United States Department of State
2022
Johns Hopkins University
2007-2015
Children's of Alabama
2015
University of Alabama at Birmingham
2015
Johns Hopkins Medicine
2013-2014
Society for Developmental and Behavioral Pediatrics
2013
Abstract Objective Epilepsy‐associated developmental lesions, including malformations of cortical development and low‐grade tumors, represent a major cause drug‐resistant seizures requiring surgical intervention in children. Brain‐restricted somatic mosaicism has been implicated the genetic etiology these lesions; however, many contributory genes remain unidentified. Methods We enrolled 50 children who were undergoing epilepsy surgery into translational research study. Resected tissue was...
This study investigates radiographically acquired normative ranges of anterior fontanelle closure (AFC) and surface area (SA) in healthy full-term infants.High-resolution head computed tomography (CT) scans were retrospectively reviewed for AFC AF dimensions to allow approximation SA.Between 15 23 CT per monthly age-group (0-24 months) reviewed, totaling 464 scans. frequency increased steadily from age 10 (16%) 20 months (88%), reaching higher than 50% at 16 (53%). The was closed 3% 5%...
Achondroplasia is the most common hereditary form of dwarfism, and characterized by short stature, macrocephaly, a myriad skeletal abnormalities. In pediatric population, stenosis compression at level cervicomedullary junction commonly occurs. The goal in this study was to assess outcomes children with achondroplasia who underwent decompression.Forty-three patients heterozygous foramen magnum 45 decompressions authors' institution over an 11-year period. After surgical decompression,...
OBJECTIVE This study investigated neurodevelopmental outcomes in preterm neonates with posthemorrhagic hydrocephalus (PHH), focusing on the comparative effectiveness of temporary and permanent CSF diversion strategies. METHODS multicenter prospective observational cohort (2012–2021) involved infants diagnosed PHH who underwent either initial or diversion. Patients were assessed using Bayley Scales Infant Toddler Development, Third Edition (BSID-III), at 15–30 months and, when possible, 36–42...
OBJECTIVE Several studies of administrative data have noted higher mortality rates for Black/African American children with shunted hydrocephalus. A longitudinal study hydrocephalus secondary to myelomeningocele showed lower lifetime shunt revision in minority compared White children, indicating a possible disparity treatment. The goal this is identify racial and ethnic disparities or by using the Hydrocephalus Clinical Research Network (HCRN) registry sample. METHODS HCRN was queried...
OBJECTIVE Subjective evaluations typically guide craniosynostosis repair. This study provides normative values of anthropometric cranial indices that are clinically useful for the evaluation multiple types and introduces 2 new in management metopic bicoronal synostosis. The authors hypothesize as well established measures like cephalic index can be drawn from CT scans normal individuals. METHODS High-resolution 3D obtained infants (age 0-24 months) were retrospectively reviewed. Calvarial...
Many genetic studies of intractable epilepsy in pediatric patients primarily focus on inherited, constitutional deficiencies identified patient blood. Recently, have revealed somatic mosaicism associated with which variants are present only a subset brain cells. We hypothesize that tissue-specific, represents an important etiology and aim to discover alterations epilepsy-affected tissue.We pursued research study identify mosaicism, using next-generation sequencing (NGS) technologies,...
Spinal column metastatic disease clinically affects thousands of cancer patients every year. Local chemotherapy represents a new option in the treatment spine. Despite clinical impact spine disease, literature currently lacks an accurate animal model for effective dosing local chemotherapeutic agents within vertebral column.Female Fischer 344 rats, weighing 150 to 200 g each, were used this study. After induction anesthesia, transabdominal approach ventral body L-6 was performed. A small...
Object Despite its diagnostic utility, head CT scanning imparts risks of radiation exposure. Children with shunt-treated hydrocephalus exhibit increased toxicity due to the higher vulnerability developing, immature tissues and frequent scanning. Several methods have been used achieve dose reduction, including modifications scanner tube current potential. This retrospective study explores use a newly defined limited sequence axial slices evaluate children shunted decrease exposure from scans....
Two previous Hydrocephalus Clinical Research Network (HCRN) studies have demonstrated that compliance with a standardized CSF shunt infection protocol reduces infections. In this third iteration, simplified consisting of 5 steps was implemented. This analysis provides an updated evaluation and evaluates modifiable risk factors.The new implemented at HCRN centers on November 1, 2016, for all procedures, excluding external ventricular drains, reservoirs, subgaleal shunts. Procedures performed...
Study Design A retrospective review. Objective To assess the utility of preoperative halo immobilization in avoidance swallowing complications-associated occipitocervical fixation. Summary Background Data The craniocervical region is commonly affected by a number pathologic processes. Fixation upper cervical spine to occiput provides an excellent means treating these conditions. Occipitocervical fixation, however, associated with potential complications. One under-reported postoperative...
OBJECTIVE The Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study 1) to determine if new, better-performing version of the Endoscopic Third Ventriculostomy Success Score (ETVSS) could be developed, 2) explore performance characteristics original ETVSS in modern endoscopic third ventriculostomy (ETV) cohort, and 3) addition radiological variables improved its predictive abilities. METHODS From April 2008 August 2019, children (corrected age ≤ 17.5 years) who underwent...
OBJECTIVE When the peritoneal cavity cannot serve as distal shunt terminus, nonperitoneal shunts, typically terminating in atrium or pleural space, are used. The comparative effectiveness of these two terminus options has not been evaluated. authors directly compared survival and complication rates for ventriculoatrial (VA) ventriculopleural (VPl) shunts a pediatric cohort. METHODS Hydrocephalus Clinical Research Network Core Data Project was used to identify children ≤ 18 years age who...
Minimally invasive magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has been proposed as an alternative to open epilepsy surgery, address concerns regarding the risk of surgery. Our primary hypothesis was that seizure freedom at 1 year after MRgLITT is noninferior surgery in children with drug-resistant (DRE). The secondary fewer complications and shorter hospitalization than objective compare outcome DRE. length two treatments.This retrospective multicenter cohort...
OBJECTIVE Endoscopic third ventriculostomy (ETV) with choroid plexus (CP) cauterization (CPC) represents a viable treatment option for congenital hydrocephalus in infants younger than 2 years. Imaging studies complement clinical data the evaluation of success or failure. The objectives this study were to investigate novel radiographic markers-cerebrospinal fluid (CSF) turbulence and CP visualization-and their ability reflect predict outcomes following ETV/CPC. METHODS Hydrocephalic patients...
Osteomyelitis of the spine with associated spinal epidural abscess represents an uncommon entity in pediatric population, requiring prompt evaluation and diagnosis to prevent neurological compromise. Cat scratch disease, caused by pathogen Bartonella henselae, encompasses a wide spectrum clinical presentations; however, association osteomyelitis has been reported only 4 other instances literature. The authors report rare case multifocal thoracic patient biopsy-proven cat disease. A...
Treating Dandy-Walker syndrome-related hydrocephalus (DWSH) involves either a CSF shunt-based or endoscopic third ventriculostomy (ETV)-based procedure. However, comparative investigations are lacking. This study aimed to compare and ETV-based treatment strategies utilizing archival data from the Hydrocephalus Clinical Research Network (HCRN) registry.
Object The aim of this study was to examine the feasibility and safety ventriculoperitoneal (VP) shunt placement using a periumbilical approach for distal peritoneal access. By minimally invasive approach, authors hypothesized that cosmetic outcomes would be better than could achieved by traditional minilaparotomy clinical results comparable. Methods A used catheter insertion during first-time VP in 20 patients (8 males 12 females). Median age at time surgery 3.0 months (range 7 days–11.9...