A5023054168- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Trauma and Emergency Care Studies
- Neuroblastoma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Facial Trauma and Fracture Management
- Iron Metabolism and Disorders
- Head and Neck Surgical Oncology
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- Obesity, Physical Activity, Diet
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
- Child Nutrition and Water Access
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Rheumatoid Arthritis Research and Therapies
University of British Columbia
2015-2025
Aligarh Muslim University
2024-2025
British Columbia Children's Hospital
2014-2024
All India Institute of Medical Sciences Rishikesh
2022
Rheumatology Consultants
2021
University College London
2011-2020
Great Ormond Street Hospital
2020
Nestlé (China)
2018
Danone (United Kingdom)
2018
Nestlé (France)
2018
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and effects on gene expression in situ are unknown. Therefore, synovial pathobiology were investigated. Methods A randomised, double-blind, phase II serial biopsy study (A3921073; NCT00976599 ) patients with RA inadequate methotrexate response. Patients background received 10 mg twice daily or placebo 28 days. Synovial biopsies performed Days -7...
Objective The Resident Activity Tracker Evaluation ( RATE ) is a prospective observational study evaluating the impact of work hours, sleep and physical activity on resident well‐being, burnout job satisfaction. Background Physician common its incidence increasing. hours well‐being remains elusive. trackers are an innovative tool for measuring activity. Methods Residents were recruited from (i) general surgery orthopaedics SURG ), (ii) internal medicine neurology MED (iii) anaesthesia...
Acute inflammation plays a significant role in the pathophysiology of traumatic brain injury (TBI). However, specific relationships between inflammatory mediators and patient outcome following TBI have not been fully established. In this study, we measured plasma cerebrospinal fluid interleukin-1 (IL-1) interleukin-6 (IL-6) concentrations 36 patients, severe TBI. Patients were monitored with continuous measurements somatosensory-evoked potentials (SSEP) to derive an established surrogate...
Abstract Medulloblastoma is the most common malignant brain tumor in children. This disease heterogeneous and composed of four subtypes medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, 4]. An immediate goal to identify novel molecular targets for aggressive forms medulloblastoma. Polo-like kinase 1 (PLK1) an oncogenic that controls cell cycle proliferation, making it a strong candidate treatment. In this study, pediatric medulloblastomas were subtyped two patient cohorts (discovery...
To perform a pilot study to assess the feasibility of performing phase III trial therapeutic hypothermia started early and continued for at least 72 hours in children with severe traumatic brain injury.Multicenter prospective randomized controlled II trial.All eight PICUs Australia New Zealand one Canada.Children 1-15 years old injury who could be within 6 injury.The control group had strict normothermia temperature 36-37°C hours. The intervention 32-33°C followed by slow rewarming rate...
Glioblastoma multiforme (GBM) ranks among the deadliest types of cancer and given these new therapies are urgently needed. To identify molecular targets, we queried a microarray profiling 467 human GBMs discovered that polo-like kinase 1 (PLK1) was highly expressed in tumors it clustered with proliferative subtype. Patients PLK1-high were more likely to die from their disease suggesting current inactive against such tumors. This prompted us examine its expression brain tumor initiating cells...
Introduction The authors reviewed the published evidence on presence of oligosaccharides in human milk (HMO) and their benefits vitro vivo studies, as well to evaluate data addition some HMOs infant formula. Method PubMed was searched from inception April 2018 Results is a dynamic process, determined by many factors such duration lactation, environmental genetic factors. may support immune function development provide protection against infectious diseases directly through interaction gut...
Analysis of the growth abnormalities in sickle cell disease has been limited by lack longitudinal observations individuals, and an inability to quantitate observed patterns. To investigate timing pattern adolescent spurt, height from Jamaican cohort study were fitted a mathematical model (Preece-Baines 1). The included 44 children with homozygous (SS) disease, age sex matched subjects haemoglobin C (SC) controls normal (AA) haemoglobin. Compared AA controls, onset spurt was delayed SS 1.4...
Ascites and abdominal pseudocysts are two complications that can occur following placement of a ventriculoperitoneal (VP) shunt. Although various factors have been implicated, the exact pathogenesis conditions remains elusive. To authors' knowledge, there no studies in which these obviously related compared.The authors retrospectively reviewed cases children with caused by VP There were 15 patients who developed pseudocyst five ascites. The analyzed to identify common distinguishing may help...
Background: The Institute of Medicine calls for the use clinical guidelines and practice parameters to promote "best practices" improve patient outcomes. In 2006, Trauma Association Canada Pediatric Committee set out create an evidence-based, national pediatric cervical spine (c-spine) clearance guideline based on literature, existing algorithms from each trauma center expert opinion across Canada. Methods: A review literature took place in September 2006 using PubMed database. Search...
The criteria for identifying patients in whom endoscopic third ventriculostomy (ETV) provides control of hydrocephalus remain evolution. In particular, it is not clear when ETV would be effective if intraventricular obstruction found preoperatively. authors postulated that 1) displacement the ventricle floor inferiorly into interpeduncular cistern and lamina terminalis anteriorly could predict clinical success ETV, 2) improvement these displacements correlate with ETV.Magnetic resonance...