A5060324072- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Autopsy Techniques and Outcomes
- Parvovirus B19 Infection Studies
- Cerebral Venous Sinus Thrombosis
- Hematological disorders and diagnostics
- Pregnancy and preeclampsia studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone and Joint Diseases
- Folate and B Vitamins Research
- Abdominal Trauma and Injuries
- Blood properties and coagulation
- Hemoglobin structure and function
- Trace Elements in Health
- Gallbladder and Bile Duct Disorders
- Neurological Complications and Syndromes
- Neurological and metabolic disorders
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Forensic and Genetic Research
University of the West Indies System
1998-2025
University of the West Indies
1987-2024
Cornwall Regional Hospital
2015-2018
Cell Medica (Switzerland)
1981-2011
University of Technology, Jamaica
1991-2005
University of the West
2004
London School of Hygiene & Tropical Medicine
1981-2004
Mulago Hospital
2004
National Institutes of Health
1985-2002
National Cancer Institute
2002
Patients with homozygous sickle-cell disease may be for alpha-thalassemia 2 (alpha-/alpha-), heterozygous (alpha-/alpha alpha), or have a normal alpha-globin-gene complement (alpha alpha/alpha alpha). We compared the clinical and hematologic features of 44 patients who had those controls two conditions. The significantly higher red-cell counts levels hemoglobin A2, as well lower F, mean corpuscular hemoglobin, concentration, volume, reticulocyte counts, irreversibly-sickled cell serum total...
A review of the causes death in 276 patients with sickle-cell disease showed that although greatest mortality occurred first five years life, roughly one-quarter were aged over 30. Commonest ten included acute splenic sequestration, septicaemia, meningitis, aplastic crises, and gastroenteritis. In older cerebrovascular accidents renal failure became common. The chest syndrome affected all age groups about equally but appeared to result predominantly from infection young embolism or thrombosis old.
In order to investigate the origin(s) of mutation(s) leading beta S-globin gene in North American populations African ancestry, we analyzed DNA polymorphisms beta-globin cluster a large number both A- and gene-bearing chromosomes U.S. Jamaican Blacks. We found 16 different haplotypes polymorphic sites associated with 170 chromosomes. The three most common S haplotypes, which account for 151/170 chromosomes, are only rarely seen bearing A-globin these (6/47). Two observations suggest multiple...
In Brief OBJECTIVE: Previous reports on pregnancy in homozygous sickle cell (SS) disease are biased by hospital-based, more severely affected subjects and may have underestimated recurrent early losses. We report outcome a representative sample of SS subsequently referred to as "subjects" or "sickle subjects," matched normal controls followed from birth. METHODS: The outcomes 94 pregnancies 52 157 68 cohort study birth presented. Outcome measures included the age at menarche, interval first...
<h3>Abstract</h3> <b>Objective:</b>To examine whether simple interventions in a sickle cell clinic improve survival disease <b>Design:</b>Survival curve analysis and hazard ratios cohort study followed from birth. <b>Setting:</b> MRC Laboratories (Jamaica) at the University of West Indies, Victoria Jubilee Hospital, Kingston, Jamaica <b>Subjects:</b>315 patients with homozygous detected during screening 100000 consecutive non-operative deliveries between June 1973 December 1981 main...
S ummary . Red cell survival was estimated in a group of adult sickle anaemia patients using the 51 Cr technique. Counts irreversibly sickled cells were performed on thin coverslip preparations capillary blood. These counts are relatively constant within same individual but show marked variations between individuals. A significant correlation has been demonstrated count and red survival. This does not apply to with splenomegaly whom is always low.
A cord blood screening programme initiated in June 1973 had screened 68 000 normal deliveries by February 1979 with the detection of 216 cases homozygous sickle cell disease. Regular review these children Medical Research Council paediatric clinic has identified acute splenic sequestration as a major cause morbidity and mortality first 5 years life. In addition to classical episodes characterised peripheral circulatory failure, minor increasing anaemia associated an enlarging spleen active...
The efficacy of prophylactic penicillin and 14 valent pneumococcal vaccine in preventing infection homozygous sickle cell (SS) disease was investigated 242 children aged 6 months to 3 years at entry. In the first five trial there were 11 infections treated group, 10 by serotypes present vaccine. Type 23 accounted for these, evidence higher rates those given before age 1. No isolations occurred group while receiving penicillin, although four within one year stopping penicillin. Probably most...
In Jamaican children with homozygous sickle cell (SS) disease diagnosed at birth two-year survival was 87%, compared 95% in cell-haemoglobin C (CS) disease, and 99% normal controls. Death among those SS occurred most often between the ages of 6 12 months. Principal causes were acute splenic sequestration pneumococcal infection. Neonatal diagnosis haemoglobinopathies must be followed by close observation if mortality is to reduced early treatment these complications.
Abstract A cord-blood screening program, designed primarily for detecting sickle cell disease, has been in operation seven months (8000 samples) at a large maternity unit Kingston, Jamaica. We describe techniques of collection and electrophoretic investigation on both cellulose acetate agar gel. These methods appear to give rapid, valid results minimal expense are well adapted populations.
Summary The details of onset, perceived precipitating factors, associated symptoms, and pain distribution in the painful crisis homozygous sickle cell (SS) disease have been prospectively recorded 183 crises 118 patients admitted to a day‐care centre Kingston, Jamaica. Painful developed most frequently between 3 p.m. midnight, commonly affected aged 15‐29 years, sexes equally, were not obviously influenced by menstrual cycle. Of skin cooling occurred 34%, emotional stress 10%, physical...