A5022636919- Spinal Cord Injury Research
- Erythropoietin and Anemia Treatment
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Cerebrospinal fluid and hydrocephalus
- Neurogenesis and neuroplasticity mechanisms
- Fetal and Pediatric Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Head and Neck Surgical Oncology
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Meningioma and schwannoma management
- Acute Ischemic Stroke Management
- Family and Disability Support Research
- Neurofibromatosis and Schwannoma Cases
- Gestational Trophoblastic Disease Studies
- Anesthesia and Pain Management
- S100 Proteins and Annexins
- Testicular diseases and treatments
- Child Abuse and Related Trauma
Universitätsmedizin Göttingen
2005-2025
University Hospital Schleswig-Holstein
2012-2024
University of Lübeck
2012-2024
Asklepios Klinik Sankt Augustin
2018-2020
British Columbia Children's Hospital
2015-2016
University of British Columbia
2015-2016
Charité - Universitätsmedizin Berlin
2016
Kiel University
2007-2015
Max Planck Institute of Experimental Medicine
1999-2005
Max Planck Society
1999-2003
Erythropoietin (EPO) and its receptor play a major role in embryonic brain, are weakly expressed normal postnatal/adult brain up-regulated upon metabolic stress. EPO protects neurons from hypoxic/ ischemic injury. The objective of this trial is to study the safety efficacy recombinant human (rhEPO) for treatment stroke man.The consisted part an part. In study, 13 patients received rhEPO intravenously (3.3 X 10(4) IU/50 ml/30 min) once daily first 3 days after stroke. double-blind randomized...
Abstract Background COVID-19 pandemic is thought to have changed the epidemiology of some pediatric neurosurgical disease: among them are intracranial complications sinusitis and otitis (ICSO). According studies on a limited number cases, both streptococci-related ICSO would increased immediately after pandemic, although reason not clear yet (seasonal changes versus pandemic-related effects). The goal present survey European Society for Pediatric Neurosurgery (ESPN) was collect large cases...
Central neuropathic pain is a frequent challenging complication after spinal cord injury (SCI), and specific therapeutic approaches remain elusive. The purpose of the present investigations was to identify potential key mediators these syndromes by analyzing detailed expression profiles important chemokines in an experimental SCI paradigm posttraumatic rats.Expression CCR1, CCL3(MIP-1α), CXCR4, CXCL12(SDF-1α) investigated parallel with behavioral testing for mechanical thermal nociceptive...
Central nervous and hematopoietic systems share developmental features. We report that thrombopoietin (TPO), a stimulator of platelet formation, acts in the brain as counterpart erythropoietin (EPO), growth factor with neuroprotective properties. TPO is most prominent postnatal brain, whereas EPO abundant embryonic decreases postnatally. Upon hypoxia, its receptor are rapidly reexpressed, neuronal down-regulated. Unexpectedly, strongly proapoptotic causing death newly generated neurons...
Spinal cord injury (SCI) often results in intractable chronic central pain syndromes. Recently chemokines such as CCL2 were identified possible key integrators of neuropathic and inflammation after peripheral nerve lesion. The focus the current study was investigation time-dependent CCR2 expression relation to development spinal impact lesions 100, 150, or 200 kdyn force on level T9 adult rats. Below-level monitored with weekly sensory testing for 42 days SCI. In parallel CCL2/CCR2 cervical,...
Due to their involvement in neuro-modulatory processes, the endogenous cannabinoid system and chemokine network, which were shown interact each other, are potential key elements cascades underlying central neuropathic pain development after spinal cord injury (SCI). Expression profiles of receptor type-1 (CB1), chemokines ligand 2 (C-C motif ) (CCL2), 3 (CCL3), plus main receptors CCR2 CCR1, investigated brain regions related pain, emotion, learning, memory a rat SCI paradigm post-traumatic...
Abstract Chemokines and their receptors play a decisive role in tumor progression metastasis. Here, we describe the expression of CXCL16‐CXCR6‐system human schwannomas different localization malignant peripheral nerve sheath tumors. The transmembrane chemokine CXCL16 its receptor CXCR6/Bonzo were overexpressed on mRNA protein levels all samples investigated as compared with normal or 8th cranial tissues. Chromogenic immunostaining confocal laser microscopy revealed that CXCR6 localized...
Previous studies have shown that glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) are potent survival factors for dopaminergic neurons and motoneurons with therapeutic potential Parkinson's disease. However, little is known about direct influences of the GFL on microglia function, which to express part GDNF receptor system. Using RT-PCR immunohistochemistrym we investigated expression alpha 1 (GFR alpha) coreceptor transmembrane tyrosine kinase (RET) in rat vitro as...
Abstract Inflammatory cascades induced by spinal cord injuries (SCI) are localized in the white matter, a recognized neural stem‐ and progenitor‐cell (NSPC) niche of adult cord. Chemokines, as integrators these processes, might also be important determinants this NSPC niche. CCL3/CCR1, CCL2/CCR2, SDF‐1α/CXCR4 were analyzed ventrolateral matter after force defined thoracic SCI: Immunoreactivity (IR) density levels measured 2 d, 7 14 42 d on cervical (C 5), (T lumbar (L 5) levels. On day post...
Cerebellar cavernous malformations (CCMs) have not been specifically described in the pediatric age group. Authors of this study, after considering published literature, describe characteristic clinical, radiological, and surgical features CCM children. METHOSDS: Patients younger than 18 years who were known to had undergone surgery between 1992 2014 at authors' institution reviewed. Pediatric cases reported literature (case reports included series on CMs group) also analyzed for specific...
Myelomeningoceles (mmc) are clinically challenging CNS malformations. Although improvement in their management has been achieved with respect to antenatal diagnosis, prevention, and fetal surgery, the cellular mechanisms of damage neural placode poorly understood. We aimed identify molecular factors lesion amplifying cascades mmc placodes. Seventeen specimens obtained during reconstructive surgery that harbored sufficient neuroepithelial tissue were investigated. Normal adult stillborn...
OBJECTIVE Focal cortical dysplasia (FCD) Type II is divided into 2 subgroups based on the absence (IIA) or presence (IIB) of balloon cells. In particular, extratemporal FCD IIA and IIB not completely understood in terms clinical, imaging, biological, neuropathological differences. The aim authors was to analyze distinctions between these formal entities address MRI, immunohistochemical features epilepsies children. METHODS Cases formerly classified as Palmini nontemporal were identified...
D-myo-inositol-1,2,6-trisphosphate (IP3) is an isomer of the naturally occurring second messenger D-myo-inositol-1,4,5-trisphosphate, and exerts anti-inflammatory antiedematous effects in lung. Myo-inositol (Inos) a component IP3, thought to play important role prevention neonatal pulmonary diseases such as bronchopulmonary dysplasia acute lung injury (nALI). Inflammatory are characterized by augmented acid sphingomyelinase (aSMase) activity leading ceramide production, pathway that promotes...