A5011964819- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Trace Elements in Health
- Diet and metabolism studies
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Neurological diseases and metabolism
- Traumatic Brain Injury Research
- Neurological Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Global Maternal and Child Health
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Long-Term Effects of COVID-19
- Neurofibromatosis and Schwannoma Cases
- Amyotrophic Lateral Sclerosis Research
Rush University Medical Center
2020-2025
Rush University
2024
Hospital for Sick Children
2024
California University of Pennsylvania
2024
Washington University in St. Louis
2024
Johns Hopkins University
2024
Cleveland Clinic
2024
Brigham and Women's Hospital
2024
Maulana Azad National Institute of Technology
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Diet may reduce Alzheimer dementia risk and slow cognitive decline, but the understanding of relevant neuropathologic mechanisms remains limited. The association dietary patterns with disease (AD) pathology has been suggested using neuroimaging biomarkers. This study examined Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Mediterranean β-amyloid load, phosphorylated tau tangles, global AD in postmortem brain tissue older adults.
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
A history of traumatic brain injury (TBI) has been considered a risk factor for Alzheimer dementia. However, the specific association TBI, even without loss consciousness (LOC), with pathologic findings that underlie dementia, including disease (AD), non-AD neurodegenerative, and vascular findings, remains unclear.To examine between TBI LOC neuropathologic in community-based cohorts.This cross-sectional analysis used data from 1689 participants Religious Orders Study, Rush Memory Aging...
Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons associated with cognitive impairment. However, little is known about the relationship between LBs LATE-NC their combined roles impairment Alzheimer's dementia community-dwelling participants. The study included 1670 community-based participants (mean age-at-death, 89.5 years (SD = 6.65); 69% females) who underwent annual assessments of cognition to create...
It is well recognized that brains of older people often harbor cerebrovascular disease pathology including vessel and vascular-related tissue injuries this associated with vascular cognitive impairment contributes to dementia. Here we review pathologies, impairment, We highlight the importance mixed co-morbid AD/non-AD neurodegenerative has been collected in multiple clinical pathologic studies, especially community-based studies. also provide an update pathologies from Rush Memory Aging...
This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.
Abstract INTRODUCTION This study investigates the inter‐related roles of hippocampal neuronal loss (HNL), limbic‐predominant age‐related TAR‐DNA binding protein 43 kDa (TDP‐43) encephalopathy neuropathologic changes (LATE‐NC), and Alzheimer's disease (ADNC) on cognitive decline. METHODS Participants underwent annual testing autopsy. HNL, ADNC, LATE‐NC, other pathologies were evaluated. Regression mixed‐effects models examined association HNL with ADNC separately Path analyses extent to which...
In this case report, we discuss a patient presenting with parkinsonism followed by non‐amnestic dementia aphasic clinical features, as well frontal dysexecutive syndrome. There was family history of an autopsy diagnosis “Pick's disease” in the proband's father. Neuroimaging revealed focal and severe temporal lobe lesser frontoparietal atrophy. At autopsy, there frontotemporal lobar degeneration. Histologic evaluation absence tau or transactivation response DNA‐binding protein 43 kDa (TDP)...
Abstract Limbic‐predominant age‐related transactive response DNA‐binding protein 43 (TDP‐43) encephalopathy neuropathologic change (LATE‐NC) and microvascular pathologies, including microinfarcts, cerebral amyloid angiopathy (CAA), arteriolosclerosis are common in old age. A relationship between LATE‐NC has been reported some but not all studies. The objectives of this study were to investigate the frequency co‐occurring pathologies test hypothesis that arteriolosclerosis, specifically, is...
Abstract Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to development Alzheimer’s disease (AD). Here, using a transcriptional network map human frontal cortex, we identify five modules co-expressed genes related microglia and assess their role in neuropathologic features AD 540 subjects from two cohort studies brain aging. Two these programs—modules 113 114—relate accumulation β-amyloid, while module 5 relates tau pathology. We replicate...
The burden of cerebrovascular disease pathologies is associated with progressive parkinsonism in older adults. We tested the hypothesis that adults using statins have a lower risk developing parkinsonism.
This study investigates the relationship between microglia inflammation in hippocampus, brain pathologies, and cognitive decline.
Abstract Grey matter ageing-related tau astrogliopathy (ARTAG) pathology is common in aged brains and detected multiple brain regions. However, the associations of grey ARTAG with Alzheimer's disease other age-related proteinopathies, addition to clinical phenotypes, including dementia cognitive decline, remain unclear. We examined 442 decedents (mean age at death = 90 years, males 32%) from three longitudinal community-based clinical–pathological studies. Using AT8 immunohistochemistry, was...
Intense monocyte activation and infiltration into the target tissues are main mechanisms of lung injury in severe acute respiratory syndrome coronavirus 2 infection. A reduction degree nature such cellular responses is expected following recovery. We aimed to investigate immune moderate disease 2019 (COVID-19) patients recovered patients.Moderate COVID-19 (n = 34) at Lok Nayak Hospital, New Delhi, 15) from mild who were considered for convalescent plasma (COPLA) donation Institute Liver...
Abstract This study examined the frequency of chronic traumatic encephalopathy-neuropathologic change (CTE-NC) and aging-related tau astrogliopathy (ARTAG) in community-dwelling older adults tested hypothesis that these pathologies are associated with a history moderate-to-severe brain injury (msTBI), defined as TBI loss consciousness >30 minutes. We evaluated CTE-NC, ARTAG, Alzheimer disease 94 participants msTBI without matched by age, sex, education, dementia status from Rush...
Abstract Introduction Higher brain tocopherol levels have been associated with lower of Alzheimer's disease (AD) neuropathology; however, the underlying mechanisms are unclear. Methods We studied relations α‐ and γ‐tocopherol to microglia density in 113 deceased participants from Memory Aging Project. used linear regression analyses examine associations between densities a basic model adjusted for age, sex, education, apolipoprotein E ( APOE )ε4 genotype (any ε4 allele vs. none) ,...