A5087397599- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Peripheral Artery Disease Management
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological and metabolic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Ultrasound and Hyperthermia Applications
- Fetal and Pediatric Neurological Disorders
- Central Venous Catheters and Hemodialysis
- Vascular Malformations Diagnosis and Treatment
- Polyomavirus and related diseases
- Renin-Angiotensin System Studies
- Congenital Anomalies and Fetal Surgery
- Cerebral Venous Sinus Thrombosis
- Blood Pressure and Hypertension Studies
Rush University Medical Center
2020-2025
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
University of Maryland, Baltimore
2012-2022
University of Rochester Medical Center
2016-2022
Rush University
2020-2021
University of Rochester
2017-2021
Nanotherapeutics (United States)
2017-2018
Blackberry (United States)
2017
Spreading edema after stroke The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown play unexpected roles neurodegeneration sleep. Mestre et al. used multimodal vivo imaging rodents found that, stroke, an abnormally large volume rushes into the brain, causing swelling (see Perspective by Moss Williams). This influx caused constrictions arteries triggered well-known...
<h3>BACKGROUND AND PURPOSE:</h3> Currently it is difficult to predict tumor response anti-angiogenic therapy in individual patients. Our aim was determine if ADC histogram analysis can stratify progression-free and overall survival patients with newly diagnosed GBM treated "up-front" (ie, before recurrence) bevacizumab. <h3>MATERIALS METHODS:</h3> Up-front bevacizumab-treated control (<i>n</i> = 59 62, respectively) were analyzed by using an approach based on enhancing tumor....
With the increased use of percutaneous intravascular diagnostic and therapeutic devices, there is potential for embolization materials introduced into vasculature. We report nine cases foreign body emboli in patients who underwent vascular procedures using hydrophilic-coated medical devices. The performed included cardiac catheterization (four cases), cerebral angiography (two with coil intracerebral aneurysm (one case), lower extremity and/or orthotopic cadaveric organ transplantation...
Background and Purpose— Subarachnoid hemorrhage (SAH) can leave patients with memory impairments that may not recover fully. Molecular mechanisms are poorly understood, no treatment is available. The sulfonylurea receptor 1–transient potential melastatin 4 (Sur1-Trpm4) channel plays an important role in acute central nervous system injury. We evaluated upregulation of Sur1-Trpm4 humans SAH and, rat models SAH, we examined upregulation, its barrier dysfunction neuroinflammation, consequences...
Background Opening of the blood-brain barrier (BBB) induced with MRI-guided focused ultrasound has been shown in experimental animal models to reduce amyloid-β plaque burden, improve memory performance, and facilitate delivery therapeutic agents brain. However, physiologic effects this procedure humans Alzheimer disease (AD) require further investigation. Purpose To assess imaging ultrasound–induced BBB opening hippocampus human participants early AD evaluate fluid flow patterns after by...
Abstract Perivascular spaces (PVS) drain brain waste metabolites, but their specific flow paths are debated. Meningeal pia mater reportedly forms the outermost boundary that confines around blood vessels. Yet, we show is perforated and permissive to PVS fluid flow. Furthermore, demonstrate comprised of vascular cerebral layers coalesce in variable patterns along leptomeningeal arteries, often merging penetrating arterioles. Heterogeneous pial architectures form sieve-like structures...
Arachnoid granulations (AG) are poorly investigated. Historical reports suggest that they regulate brain volume by passively transporting cerebrospinal fluid (CSF) into dural venous sinuses. Here, we studied the microstructure of cerebral AG in humans with aim understanding their roles physiology. We discovered marked variations size, lobation, location, content, and degree surface encapsulation. High-resolution microscopy shows consist outer capsule inner stromal core regions. The fine...
Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in humans are incompletely understood. Here, we assessed physiologic responses to FUS administered multifocal brain sites of persons with Alzheimer’s disease (AD). Methods At tertiary neuroscience institute, eight participants AD (mean age 65, 38% F) enrolled phase 2 clinical trial underwent three successive targeted...
Abstract INTRODUCTION To study the relationship of late‐life hemoglobin A1C (A1C) with postmortem neuropathology in older adults and without diabetes mellitus (DM). METHODS A total 990 participants from five cohort studies aging dementia at least two annually‐collected measures, who had autopsy. Neuropathologic evaluations documented cerebrovascular disease, Alzheimer's disease (AD), other pathologies. evaluate association mean variability (standard deviation [SD]) neuropathology, we used a...
Disability or death occurs more frequently in patients with hemorrhagic transformation (HT) after ischemic stroke. In rat models of stroke, sulfonylurea (SU) drugs such as glibenclamide (adopted US name, glyburide) confer protection against swelling and HT through actions on the novel SUR1-regulated NC(Ca-ATP) channel. Here, we sought to determine whether use SU diabetes mellitus (DM) presenting acute stroke might influence incidence HT.We retrospectively analyzed data 220 DM who presented...
The nonselective monovalent cation channel transient receptor potential melastatin 4 (Trpm4) is transcriptionally upregulated in neural and vascular cells animal models of brain infarction. It associates with sulfonylurea 1 (Sur1) to form Sur1-Trpm4 channels, which have critical roles cytotoxic edema, cell death, blood-brain barrier breakdown, vasogenic edema. We examined Trpm4 expression postmortem specimens from 15 patients who died within the first 31 days onset focal cerebral ischemia....
A history of traumatic brain injury (TBI) has been considered a risk factor for Alzheimer dementia. However, the specific association TBI, even without loss consciousness (LOC), with pathologic findings that underlie dementia, including disease (AD), non-AD neurodegenerative, and vascular findings, remains unclear.To examine between TBI LOC neuropathologic in community-based cohorts.This cross-sectional analysis used data from 1689 participants Religious Orders Study, Rush Memory Aging...
Subarachnoid hemorrhage (SAH) can lead to disabling motor, cognitive, and neuropsychological abnormalities. Part of the secondary injury cerebral tissues associated with SAH is attributable neuroinflammatory response induced by blood. Heparin a pleiotropic compound that reduces inflammatory responses in conditions outside central nervous system. Using model devoid global insult, we evaluated effect delayed intravenous (IV) infusion heparin, at dose does not produce therapeutic...
Ischemic stroke, a major cause of mortality, is frequently accompanied by life-threatening cerebral edema. Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, important molecular contributor to edema formation. Past studies Aqp4 expression and localization after ischemia examined grey matter exclusively. However, as white astrocytes differ developmentally, physiologically, molecularly from astrocytes, we hypothesized that functionally regional heterogeneity exists in subcellular...
Background and Purpose: Enlarged perivascular spaces (EPVS) have been associated with aging, increased stroke risk, decreased cognitive function, vascular dementia. However, the relationship of EPVS age-related neuropathologies is not well understood. Therefore, purpose this study was to assess neuropathologic correlates in a large community-based cohort older adults. The over beyond those other pathologies were also assessed. Methods: This included 654 deceased autopsied participants 3...
Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that shortly anoxia secondary to terminal depolarizations the abnormal entry CSF. Oedema severity correlated with availability CSF age-dependent increase in volume worsening oedema. was identified primarily regions bordering compartments mice humans. The degree ex vivo tissue swelling predicted by an osmotic model suggesting possesses a high intrinsic...
This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.