A5026539778- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Physiological and biochemical adaptations
- Reproductive biology and impacts on aquatic species
- Environmental Quality and Pollution
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Geomechanics and Mining Engineering
- Computational Drug Discovery Methods
- Geoscience and Mining Technology
- Fish Ecology and Management Studies
- Metabolomics and Mass Spectrometry Studies
- Parasite Biology and Host Interactions
- Invertebrate Immune Response Mechanisms
- Myxozoan Parasites in Aquatic Species
- interferon and immune responses
- Genetic and phenotypic traits in livestock
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Animal Genetics and Reproduction
- Landslides and related hazards
- Environmental and Agricultural Sciences
- Machine Learning in Bioinformatics
- Creativity in Education and Neuroscience
- Eicosanoids and Hypertension Pharmacology
Memorial University of Newfoundland
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
University of Jordan
2024
Weatherford College
2024
Guangxi University
2021-2022
Waseda University
2022
University of California, Los Angeles
2011-2019
New York University
2018
Xi'an University of Science and Technology
2013-2015
Xi'an Jiaotong University
2014
<h3>BACKGROUND AND PURPOSE:</h3> Currently it is difficult to predict tumor response anti-angiogenic therapy in individual patients. Our aim was determine if ADC histogram analysis can stratify progression-free and overall survival patients with newly diagnosed GBM treated "up-front" (ie, before recurrence) bevacizumab. <h3>MATERIALS METHODS:</h3> Up-front bevacizumab-treated control (<i>n</i> = 59 62, respectively) were analyzed by using an approach based on enhancing tumor....
Abstract Background Increases in ocean temperatures and the frequency severity of hypoxic events are expected with climate change, may become a challenge for cultured Atlantic salmon negatively affect their growth, immunology welfare. Thus, we examined how an incremental temperature increase alone (Warm & Normoxic-WN: 12 → 20 °C; 1 °C week − ), combination moderate hypoxia Hypoxic-WH: ~ 70% air saturation), impacted salmon’s hepatic transcriptome expr\ession compared to control fish (CT:...
Dependence on marine natural resources threatens the sustainability of Atlantic salmon aquaculture. In present study, fed for 14 weeks with an experimental diet based animal by-products and vegetable oil (ABP) exhibited reduced growth performance compared others a fish meal/fish (MAR) plant protein/vegetable oil-based (VEG). To characterize molecular changes underlying differences in performance, we conducted 44 K microarray study liver transcriptome three dietary groups. The experiment...
Due to the limited availability and high cost of fish oil in face increasing aquaculture production, there is a need reduce usage aquafeeds without compromising farm health. Therefore, present study was conducted determine if different levels vegetable oils can alter antiviral responses salmon macrophage-like cells (MLCs). Atlantic (Salmo salar) were fed diets containing 7.4% (FO7) or 5.1% (FO5) oil. These designed be relatively low EPA + DHA (i.e. FO7: 1.41% FO5: 1%), but near requirement...
Parasitic sea lice (e.g., Lepeophtheirussalmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated early transcriptomic pelvic fins of Atlantic parasitized with chalimus I stage lice. Fin samples collected from non-infected (i.e. pre-infected) control (PRE) and at chalimus-attachment sites (ATT) adjacent to (ADJ) infected fish were used profiling global gene expression...
Gill damage represents a significant challenge in the teleost fish aquaculture industry globally, due to gill's involvement several vital functions and direct contact with surrounding environment. To examine local systemic effects accompanying gill (which is likely negatively affect function) of Atlantic salmon, we performed field sampling collect liver tissue after environmental insults (e.g., harmful algal blooms). Before sampling, gills were visually inspected was scored; scores assigned...
MicroRNAs (miRNAs) are key regulators in fish immune responses. However, no study has previously characterized the impact of polyriboinosinic polyribocytidylic acid (pIC) and formalin-killed typical Aeromonas salmonicida (ASAL) on miRNA expression Atlantic salmon fed a commercial diet with without immunostimulant CpG. To this end, first, we performed small RNA deep sequencing qPCR analyses to identify confirm pIC- and/or ASAL-responsive miRNAs head kidney control diet. DESeq2 identified 12...
Salmonid rickettsial septicemia (SRS), caused by Piscirickettsia salmonis, is one of the most devastating diseases salmonids. However, transcriptomic responses Atlantic salmon (Salmon salar) in freshwater to an EM-90-like isolate have not been explored. Here, we infected parr with and conducted time-course qPCR analyses pathogen load four biomarkers (campb, hampa, il8a, tlr5a) innate immunity on head kidney samples. Transcript expression three these genes (except hampa), as well level,...
The inclusion of plant meals in diets farmed Atlantic salmon can elicit inflammatory responses the distal intestine (DI). For present work, fish were fed a standard meal (FM) diet or with partial replacement FM solvent-extracted camelina (CM) (8, 16, 24 % CM inclusion) during 16-week feeding trial. A significant decrease growth performance was seen all (Hixson et al. Aquacult Nutr 22:615–630, 2016). 4x44K oligonucleotide microarray experiment carried out and significance analysis microarrays...
Abstract The rational design of chemical entities with desired properties for a specific target is long-standing challenge in drug design. Generative neural networks have emerged as powerful approach to sample novel molecules properties, termed inverse However, generating biological activity against certain targets and predefined still remains challenging. Here, we propose conditional molecular generation net (CMGN), the backbone which bidirectional autoregressive transformer. CMGN applies...
Library matching by comparing carbon-13 nuclear magnetic resonance (13C NMR) spectra with spectral data in the library is a crucial method for compound identification. In our previous paper, we introduced deep contrastive learning system called CReSS, which used that contained more structures. However, CReSS has two limitations: there were no unknown structures library, and redundant reduces structure-elucidation accuracy. Herein, replaced oversize traditional libraries focused containing...
Abstract The immunomodulatory effects of omega-3 and omega-6 fatty acids are a crucial subject investigation for sustainable fish aquaculture, as oil is increasingly replaced by terrestrial vegetable oils in aquafeeds. Unlike previous research focusing on replacement with alternatives, our study explored how the to polyunsaturated acid (PUFA) ratio low-fish aquafeeds influences Atlantic salmon's antiviral antibacterial immune responses. salmon were fed rich soy (high omega-6) or linseed...
Viperin is a key antiviral effector in immune responses of vertebrates including the Atlantic cod (Gadus morhua). Using cloning, sequencing and gene expression analyses, we characterized viperin at nucleotide hypothetical amino acid levels, its regulating factors were investigated. cDNA 1,342 bp long, predicted protein contains 347 acids. silico showed that composed 5 exons, as other vertebrate orthologs. In addition, radical SAM domain C-terminal sequences are highly conserved among various...
Lepeophtheirus salmonis (sea lice) and bacterial co-infection threatens wild farmed Atlantic salmon performance welfare. In the present study, pre-adult L. salmonis-infected non-infected were intraperitoneally injected with either formalin-killed Aeromonas salmonicida bacterin (ASAL) or phosphate-buffered saline (PBS). Dorsal skin samples from each injection/infection group (PBS/no lice, PBS/lice, ASAL/no ASAL/lice) collected at 24 h post-injection used for transcriptome profiling using a...
Abstract Moritella viscosa is a Gram-negative pathogen that causes large, chronic ulcers, known as winter-ulcer disease, in the skin of several fish species including Atlantic salmon. We used bath challenge approach to profile transcriptome responses M. -infected salmon at lesion (Mv-At) and away from (Mv-Aw) sites. infection was confirmed through RNA-based qPCR assays. RNA-Seq identified 5212 2911 transcripts differentially expressed Mv-At compared no-infection control Mv-Aw groups,...