A5053407441- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Antioxidant Activity and Oxidative Stress
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
- Advanced Chemical Sensor Technologies
- Renal Transplantation Outcomes and Treatments
- Asthma and respiratory diseases
- Animal Genetics and Reproduction
- Electrospun Nanofibers in Biomedical Applications
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Additive Manufacturing and 3D Printing Technologies
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Aquaculture disease management and microbiota
- Gas Sensing Nanomaterials and Sensors
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Algal biology and biofuel production
- Analytical Chemistry and Sensors
Memorial University of Newfoundland
2017-2025
Simon Fraser University
2021-2022
University of Waterloo
2022
Alzahra University
2013
The evolutionary arms race between host restriction factors and viral antagonists provides crucial insights into immune system evolution adaptation. This study investigates the structural dynamics of double-domain A3F A3G their inhibitor, Vif, across diverse primate species. By constructing 3D homology models integrating ancestral sequence reconstruction (ASR), we identified patterns diversity, conservation, functional Inactive CD1 (Catalytic Domain 1) domains displayed greater diversity...
Activation-induced cytidine deaminase (AID) initiates antibody diversification by mutating immunoglobulin loci in B lymphocytes. AID and related APOBEC3 (A3) enzymes also induce genome-wide mutations lesions implicated tumorigenesis tumor progression. The most prevalent mutation signatures across diverse genomes are attributable to the mistargeted mutagenic activities of AID/A3s. Thus, inhibiting AID/A3s has been suggested be therapeutic benefit. We previously used a...
Viperin is a key antiviral effector in immune responses of vertebrates including the Atlantic cod (Gadus morhua). Using cloning, sequencing and gene expression analyses, we characterized viperin at nucleotide hypothetical amino acid levels, its regulating factors were investigated. cDNA 1,342 bp long, predicted protein contains 347 acids. silico showed that composed 5 exons, as other vertebrate orthologs. In addition, radical SAM domain C-terminal sequences are highly conserved among various...
Activation-induced cytidine deaminase (AID) mutates immunoglobulin genes and acts genome-wide. AID targets robustly transcribed genes, purified on single-stranded (ss) but not double-stranded (ds) DNA oligonucleotides. Thus, it is believed that transcription the generator of ssDNA for AID. Previous cell-free studies examining relationship between targeting have employed a bacterial colony count assay wherein reverts an antibiotic resistance stop codon in plasmid substrates, leading to...
Abstract Background Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification by mutating immunoglobulin loci. AID-driven is conserved across jawed since bony and cartilaginous fish. Two exceptions have recently been reported, Pipefish Anglerfish, AID-encoding aicda gene has lost. Both cases are associated with unusual reproductive behavior, including male pregnancy sexual parasitism. Several...
Activation-induced cytidine deaminase (AID) is a member of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family deaminases. AID mutates immunoglobulin loci to initiate secondary antibody diversification. The APOBEC3 (A3) sub-branch viral pathogens in cytosol and acidic endosomal compartments. Accordingly, functions optimally near-neutral pH, while most A3s are acid-adapted (optimal pH 5.5-6.5). To gain structural understanding for this disparity, we...
Purpose: We aim to discuss the current status of knowledge on role recently identified cytokines in airway hyper responsiveness as well genetic predisposition conferred by their coding genes asthma. Methods: focused three and genes,IL-9, IL-17, IL-22, conducted a narrative review all relevant publications known authors. Results: A great body evidence regarding involvement these asthma was discussed interpreted. These range from studies murine models clinical human approaches. Despite large...
Abstract We report a highly sensitive and fully printable capacitive humidity sensor based on zinc oxide (ZnO) polyethylenimine (PEI) composite. The has simple structure, consisting only of layer the ZnO:PEI composite, coated using an ethanol solution, silver inter-digital electrodes that have been pre-printed polyethyleneterephthalate substrate. with in ratio 2:1 by volume exhibits response 43 907 000% at maximum humidity, detection range 15%–95% relative higher than other sensors made...