John H. Thomas

ORCID: 0000-0002-7127-8654
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About
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Research Areas
  • Solar and Space Plasma Dynamics
  • Astro and Planetary Science
  • Geomagnetism and Paleomagnetism Studies
  • Cerebrospinal fluid and hydrocephalus
  • Geophysics and Gravity Measurements
  • Stellar, planetary, and galactic studies
  • Fetal and Pediatric Neurological Disorders
  • Solar Radiation and Photovoltaics
  • Ionosphere and magnetosphere dynamics
  • Spinal Dysraphism and Malformations
  • Botany, Ecology, and Taxonomy Studies
  • Advanced Neuroimaging Techniques and Applications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Geophysics and Sensor Technology
  • Scientific Research and Discoveries
  • Oceanographic and Atmospheric Processes
  • Fluid Dynamics and Turbulent Flows
  • Botany and Plant Ecology Studies
  • Historical Astronomy and Related Studies
  • Meteorological Phenomena and Simulations
  • Renal Transplantation Outcomes and Treatments
  • Pulsars and Gravitational Waves Research
  • Astrophysics and Star Formation Studies
  • Rangeland and Wildlife Management
  • Archaeology and Natural History

University of Rochester
2009-2025

Florida International University
2009-2021

Phoenix Houses of New England
2021

Mott MacDonald (United Kingdom)
2017

Oregon Medical Research Center
2017

Oregon Health & Science University
2017

Fort Environmental Laboratories (United States)
2003-2006

University of Cambridge
1966-2005

Isaac Newton Institute for Mathematical Sciences
2005

Auburn University
1998

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is important for clearance metabolic waste. Arterial pulsations are thought to drive flow, but this has never been quantitatively shown. We used particle tracking quantify CSF flow velocities PVSs live mice. pulsatile and driven primarily by cardiac cycle. The speed arterial wall matches that CSF, suggesting motion principal driving mechanism, via a process known as pumping. Increasing blood pressure leaves...

10.1038/s41467-018-07318-3 article EN cc-by Nature Communications 2018-11-13

Spreading edema after stroke The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown play unexpected roles neurodegeneration sleep. Mestre et al. used multimodal vivo imaging rodents found that, stroke, an abnormally large volume rushes into the brain, causing swelling (see Perspective by Moss Williams). This influx caused constrictions arteries triggered well-known...

10.1126/science.aax7171 article EN Science 2020-01-31

The flow of cerebrospinal fluid along perivascular spaces (PVSs) is an important part the brain’s system for delivering nutrients and eliminating metabolic waste products (such as amyloid-β); it also offers a pathway delivery therapeutic drugs to brain parenchyma. Recent experimental results have resolved several questions about this flow, setting stage advances in our understanding its dynamics. This review summarizes new evidence provides critical evaluation previous fluid-dynamic models...

10.1098/rsif.2019.0572 article EN cc-by Journal of The Royal Society Interface 2019-10-23

Purpose This paper aims to review the extant hospitality and tourism literature on state of robotics artificial intelligence (AI) in service industry. The aim was highlight current areas research this emerging topic identify for future application study. Design/methodology/approach A list journals used articles related AI using terms AI, robots, robotics, tourism, several combinations thereof. Additional sources were identified through reviews from works. Findings findings revealed studies...

10.1108/jhtt-07-2018-0066 article EN Journal of Hospitality and Tourism Technology 2019-10-08

Periarterial spaces (PASs) are annular channels that surround arteries in the brain and contain cerebrospinal fluid (CSF): a flow of CSF these is thought to be an important part brain's system for clearing metabolic wastes. In vivo observations reveal they not concentric, circular annuli, however: outer boundaries often oblate, form inner offset from central axis.

10.1186/s12987-019-0140-y article EN cc-by Fluids and Barriers of the CNS 2019-06-19

Cerebrospinal fluid (CSF) flowing through periarterial spaces is integral to the brain’s mechanism for clearing metabolic waste products. Experiments that track tracer particles injected into cisterna magna (CM) of mouse brains have shown evidence pulsatile CSF flow in perivascular surrounding pial arteries, with a bulk same direction as blood flow. However, driving remains elusive. Several studies suggested might be an artifact, driven by injection itself. Here, we address this hypothesis...

10.7554/elife.65958 article EN cc-by eLife 2021-03-09

Circulation of cerebrospinal fluid and interstitial around the central nervous system through brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, metabolic wastes. Passing tissue primarily during sleep, this circulation has implications for neurodegenerative disorders Alzheimer's disease, damage stroke cardiac arrest, flow-related such as hydrocephalus syringomyelia. Recent experimental results reveal several features flow, other...

10.1146/annurev-fluid-120720-011638 article EN cc-by Annual Review of Fluid Mechanics 2022-09-28

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain delivers nutrients, clears metabolic waste, and causes edema formation. Brain-wide imaging cannot resolve PVSs, high-resolution methods access deep tissue. However, theoretical models provide valuable insight. We model CSF pathway as a network hydraulic resistances, using published parameter values. A few parameters (permeability PVSs parenchyma, dimensions astrocyte endfoot gaps) have wide uncertainties, so we...

10.1016/j.isci.2022.104258 article EN cc-by iScience 2022-04-14

Quantifying the flow of cerebrospinal fluid (CSF) is crucial for understanding brain waste clearance and nutrient delivery, as well edema in pathological conditions such stroke. However, existing vivo techniques are limited to sparse velocity measurements pial perivascular spaces (PVSs) or low-resolution from brain-wide imaging. Additionally, volume rate, pressure, shear stress variation PVSs essentially impossible measure vivo. Here, we show that artificial intelligence velocimetry (AIV)...

10.1073/pnas.2217744120 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2023-03-29

▪ Abstract Important physical processes on the Sun, and especially in sunspots, occur spatial scales at or below limiting resolution of current solar telescopes. Over past decade, using a number new techniques, high-resolution observations have begun to reveal complex thermal magnetic structure sunspot, along with associated flows oscillations. During this time remarkable advances computing power allowed significant progress our theoretical understanding dynamical processes, such as...

10.1146/annurev.astro.42.010803.115226 article EN Annual Review of Astronomy and Astrophysics 2004-08-17

Intracranial cerebrospinal and interstitial fluid (ISF) flow solute transport have important clinical implications, but limited in vivo access to the brain interior leaves gaping holes human understanding of nature these neurophysiological phenomena. Models can address some gaps, only insofar as model inputs are accurate. We perform a sensitivity analysis using Monte Carlo approach on lumped-parameter network ISF perivascular extracellular spaces murine brain. place bounds predictions given...

10.1098/rsif.2022.0257 article EN Journal of The Royal Society Interface 2022-06-01

view Abstract Citations (110) References (22) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Siphon Flows in Isolated Magnetic Flux Tubes Thomas, John H. Previous studies of siphon flows magnetic flux tubes have been limited to the case a low-β plasma, appropriate for an embedded tube solar corona or chromosphere. Here author steady isolated, thin surrounded by field-free gas, with plasma β ≥ 1, conditions photosphere. The presents basic equations...

10.1086/166756 article EN The Astrophysical Journal 1988-10-01

A theoretical treatment of magneto-atmospheric waves is presented and applied to the modelling in solar atmosphere. The arise compressible, stratified, electrically conductive atmospheres within gravitational fields when permeated by a magnetic field. Compression, buoyancy, distortion field all contribute existence waves. Basic linearized equations are introduced describe attention given plane-stratified their stability. dispersion relation defined for wave propagation atmosphere there no...

10.1146/annurev.fl.15.010183.001541 article EN Annual Review of Fluid Mechanics 1983-01-01
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