A5005951515- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Ginkgo biloba and Cashew Applications
- Diet, Metabolism, and Disease
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- Advanced Glycation End Products research
- Biochemical Analysis and Sensing Techniques
- Piperaceae Chemical and Biological Studies
- Herbal Medicine Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Ischemia and Reperfusion
- Antifungal resistance and susceptibility
- Phytochemicals and Medicinal Plants
- Pharmacological Effects of Natural Compounds
- Chemotherapy-induced organ toxicity mitigation
- Antimicrobial Peptides and Activities
- Bryophyte Studies and Records
- Orthoptera Research and Taxonomy
- Infections and bacterial resistance
- Essential Oils and Antimicrobial Activity
- Synthesis and Reactions of Organic Compounds
- Advances in Cucurbitaceae Research
- Cancer therapeutics and mechanisms
- Phytochemicals and Antioxidant Activities
Sir Takhtasinhji General Hospital
2024
All India Institute of Medical Sciences Bhubaneswar
2020-2024
Goa University
2024
Bombay College of Pharmacy
2008-2014
Sinhgad Dental College and Hospital
2009-2013
Al-Ameen Medical College
2012
Antibiotic Research UK
1990-2011
Savitribai Phule Pune University
2010
University of Mumbai
2005-2009
Unilever (India)
1984-2000
Abstract Background The MCE, Momordica charantia fruit extract Linn. (Cucurbitaceae) have been documented to elicit hypoglycemic activity on various occasions. However, due lack of standardization these extracts, their efficacy remains questionable. present study was undertaken by selecting a well standardised MCE. This reports and antilipidemic activities MCE employing relevant animal models in vitro methods. Methods Diabetes induced Wistar rats s.c., subcutaneous injection alloxan...
Abstract Aim: The protective effects of Ginkgo biloba phytosomes (GBP) on carbon tetrachloride (CCl 4 )‐induced hepatotoxicity and the probable mechanism(s) involved in this protection were investigated rats. Methods: Liver damage was induced Wistar rats by administering a 1:1 (v/v) mixture CCl olive oil (1 ml/kg, i.p.) once daily for 7 days. GBP at 25 mg/kg 50 mg/kg, i.p. reference drug silymarin (200 p.o.) administered 10 days to ‐treated rats, treatment beginning 3 prior commencement...
Piperine (1-peperoyl piperidine) was isolated from Piper nigrum Linn for the evaluation of anti-inflammatory activity in rats. Different acute and chronic experimental models like carrageenin-induced rat paw edema, cotton pellet granuloma, croton oil-induced granuloma pouch, were employed. Simultaneously, biochemical estimations made to elucidate underlying mechanism action. acted significantly on early changes inflammatory processes granulative changes. It also partially through stimulation...
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
Abstract Ginkgo biloba from the traditional Chinese system of medicine has been found to possess neurocognitive enhancing effects. The mechanism action seems be related its antioxidant properties. In present study, phytosomes were administered Wistar rats at 50 mg/kg and 100 for 7 14 days. Chemical hypoxia was induced by administration sodium nitrite (75 mg/kg) 1 h after last treatment. Thirty minutes administration, animals killed cerebral cortex, cerebellum, hippocampus striatum isolated...
The immunomodulatory activity of HN-02, an extract containing a mixture andrographolides (i.e., andrographolide [88 ± 5 %] plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 3 %]) in pure powder form was evaluated at 1.0, 1.5, 2.5 mg/kg on different vivo vitro experimental models. In delayed-type hypersensitivity (DTH) mouse model, potentiation the DTH reaction observed after treatment with cyclophosphamide (CYP) HN-02 individually. However, CYP reversed by...
The present study reports the anti-allergic activity of ethanolic extract Zizyphus jujuba Mill., Rhamnaceae, and its possible mode action. effect Z. at different doses (250, 500 1000 mg/kg, orally) was simulated on studied animal models asthma allergy: a) milk induced eosinophilia leukocytosis; b) compound 48/80 mast cell degranulation; and, c) active passive cutaneous anaphylaxis. In addition, jujuba's sensitized guinea pig ileum (ex vivo) tracheal chain preparations (invitro) were...