A5076354428- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Forecasting Techniques and Applications
- Acute Ischemic Stroke Management
- demographic modeling and climate adaptation
- Blood groups and transfusion
- Acute Myocardial Infarction Research
- Hemophilia Treatment and Research
- Complement system in diseases
- Monetary Policy and Economic Impact
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Hemoglobinopathies and Related Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Glioma Diagnosis and Treatment
- Complex Systems and Time Series Analysis
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Protease and Inhibitor Mechanisms
- Power Transformer Diagnostics and Insulation
- Blood transfusion and management
- High voltage insulation and dielectric phenomena
- Hemostasis and retained surgical items
Indiana University – Purdue University Indianapolis
2023-2025
Indiana University School of Medicine
2023-2025
Central Michigan University
2025
United States Census Bureau
1998-2024
Queen's University Belfast
2024
Indiana University Health
2024
National Hospital
2024
Boston University
2024
VA Puget Sound Health Care System
2024
University of Washington
2024
The mechanism of cytotoxicity 6-hydroxydopamine, 2,4,5-trihydroxyphenylalanine, dopa, dopamine, norepinephrine, and epinephrine was explored by asking whether a reflection the potential for autoxidation each polyphenol or sulfhydryl reactivity its quinone products. polyphenols, as measured inhibition [3H]thymidine incorporation into DNA C1300 neuroblastoma cells in tissue culture, correlated with rate autoxidation, spectrophotometrically oxygen electrode studies. Polarographic determinations...
Thrombotic thrombocytopenic purpura—hemolytic uremic syndrome (TTP-HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction. In early reports the mortality approached 100 percent. A treatment protocol was introduced in 1979 for patients admitted to Johns Hopkins Hospital with diagnosis of TTP-HUS. Treatment regimens included 200 mg prednisone a day, minimal symptoms no symptoms, plus plasma exchange,...
The antiplatelet drug clopidogrel is a new thienopyridine derivative whose mechanism of action and chemical structure are similar to those ticlopidine. estimated incidence ticlopidine-associated thrombotic thrombocytopenic purpura 1 per 1600 5000 patients treated, whereas no clopidogrel-associated cases were observed among 20,000 closely monitored treated in phase 3 clinical trials cohort studies. Because the association between ticlopidine use other adverse effects, has largely replaced...
TROUSSEAU'S SYNDROME AND OTHER MANIFESTATIONS OF CHRONIC DISSEMINATED COAGULOPATHY IN PATIENTS WITH NEOPLASMS: PDF Only
X-12-ARIMA is the Census Bureau's new seasonal-adjustment program. It provides four types of enhancements to X-ll-ARIMA—(1) alternative seasonal, trading-day, and holiday effect adjustment capabilities that include adjustments for effects estimated with user-defined regressors; additional seasonal trend filter options; an seasonal-trend-irregular decomposition; (2) diagnostics quality stability achieved under options selected; (3) extensive time series modeling model-selection linear...
Abstract The decision on whether or not to include a unit root in an autoregressive operator has profound implications. Formal tests for the presence of roots give analysts objective guidance this decision. This article is practical guide use these tests. Key Words: Time seriesNonstationaryUnit rootHypothesis test
From the Departments of Medicine and Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
Journal Article A Probability Model for the Measurement of Ecological Segregation Get access Wendell Bell Stanford University Search other works by this author on: Oxford Academic Google Scholar Social Forces, Volume 32, Issue 4, May 1954, Pages 357–364, https://doi.org/10.2307/2574118 Published: 01 1954
In a group of 52 patients receiving continuous intravenous heparin, 16 developed thrombocytopenia (platelets < 100 000/mm3). Ten the who had elevated titers fibrinogen-fibrin degradation products, and five these 10 also reduction in plasma fibrinogen. The abnormalities disappeared after heparin preparation was discontinued. These occurrences could not be attributed to drugs other than dose administered, or prior exposure heparin. mechanism by which may induce changes is known.
In the first part of this article, we briefly review history seasonal adjustment and statistical time series analysis in order to understand why methods have evolved into their present form. This provides insight some problems that must be addressed by procedures points out advances modern raise question whether should performed at all. turn leads a discussion second issues invloved adjustment. We state our opinions about raised renew work authors. First, comment on reasons been given for...
The nonstationary signal extraction problem is to estimate $s_t$ given observations on $z_t = s_t + n_t$ (signal plus noise) when either or $n_t$ both nonstationary. Homogeneous explosive time series described by models of the form $\delta(B)z_t w_t$ where $\delta(B)$ has zeroes inside unit circle and $w_t$ stationary are considered. For certain cases, approximate solutions have been Hannan (1967), Sobel Cleveland Tiao (1976). paper gives exact in forms expressions for $E(s_t\mid\{z_t\})$...
Synthetic cluster glycosides containing either one, two, or three galactosyl lactosyl residues per ligand were used to test the effect of carbohydrate clustering on binding by rabbit hepatic Gal/GalNAc-binding lectin using isolated hepatocytes solubilized, affinity-purified lectin. The tris- and bis-glycosides superior mono-glycosides for inhibition 125I-asialoorosomucoid at 0 degrees C. concentrations tris-glycosides required 50% (4-8 microM) 50-100 times lower than corresponding (400-500...
We performed a prospective, double-blind study of the incidence thrombocytopenia in 149 patients randomly assigned to treatment with one three heparin preparations--from bovine lung from intestinal-mucosa A, or O. Thrombocytopenia developed 21 (platelets, < 100 x 10(9) per liter): 13 50 receiving heparin, four 45 intestinal-mucosa-A and 54 intestinal-musoca-O (P 0.005). There was significantly increased bovine-lung group 0.002); estimated rates after nine days were 24 cent this 7 combined A...
Symposium1 July 1980Thrombolytic Therapy in Thrombosis: A National Institutes of Health Consensus Development ConferenceSOL SHERRY, WILLIAM R. BELL, F. H. DUCKERT, ANTHONY P. FLETCHER, VICTOR GUREWICH, DAVID M. LONG, J. MARDER, HAROLD ROBERTS, EDWIN W. SALZMAN, ARTHUR SASAHARA, MARC VERSTRAETESOL VERSTRAETEAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions...
TWO agents that induce thrombolytic activity have recently been approved for clinical use by the Food and Drug Administration: streptokinase (marketed as Streptase Hoechst-Roussel Pharmaceuticals, Somerville, NJ, Kabikinase Kabi Group, Greenwich, CT) urokinase Abbokinase Abbott Laboratories, North Chicago, IL).1 These drugs activate plasminogen thus cause formation of proteolytic enzyme plasmin. (Other with potential activating human fibrinolytic system include Thrombolysin Actase. are...
Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led the Age-Related Eye Disease Study, which showed supplements containing antioxidant vitamins and zinc reduce risk of progression severe stages AMD. Despite these data indirectly implicate oxidative damage pathogenesis AMD, there has not been any direct demonstration increased retinas In...
Amino acid and carbohydrute composition of fibrinogen, constituent chains, derived glycopeptides
Two patients receiving intravenous heparin for pulmonary emboli developed disseminated intravascular coagulation during therapy. Both were adequate anticoagulation before the onset of this syndrome. Mechanisms that might cause or prolong therapy are proposed.
Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and profiles age-matched subjects with PART AD pathology.Brain autopsies (n = 183) were conducted on participants 85 years older from Baltimore Longitudinal Study Aging Johns Hopkins Disease Research Center. Participants, normal at enrollment,...