A5018331813- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Infectious Diseases and Tuberculosis
- Ocular Diseases and Behçet’s Syndrome
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Eosinophilic Esophagitis
- Retinal and Optic Conditions
- Atherosclerosis and Cardiovascular Diseases
- Syphilis Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Complement system in diseases
- Streptococcal Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Spondyloarthritis Studies and Treatments
- Liver Diseases and Immunity
Universidade Federal do Rio de Janeiro
2009-2025
Secretaria de Agricultura e Abastecimento
2024
Universidade Veiga de Almeida
2024
Indiana University School of Medicine
2024
Boston University
2024
VA Puget Sound Health Care System
2024
University of Washington
2024
National Hospital
2024
Indiana University
2024
University School
2024
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
Objective. The most widely used classification criteria for SLE are those derived and validated in adult patients by the ACR. Alternatives include Boston weighted (BW) SLICC criteria. aim of this study was to compare performance BW with 1997 ACR a JSLE cohort. Methods. Cases were controls other rheumatic diseases attending tertiary centre past 10 years. Data retrospectively collected establish ACR, fulfilled at first visit within year follow-up. A consensus diagnosis established same group...
To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). This study aims to compare the performance among American College of Rheumatology (ACR) 1997, Systemic Lupus International Collaborating Clinics (SLICC) and new European League Against Rheumatism (EULAR)/ACR criteria, in a cSLE cohort. We conducted medical chart review cases controls with defined rheumatic diseases, both ANA positive, establish each ACR1997, SLICC EULAR/ACR...
O presente trabalho teve como objetivo avaliar os sistemas de mulching com filme plástico e papelão sobre a produtividade desenvolvimento da alface. ensaio foi conduzido em área experimental do IF Goiano Campus Cristalina. delineamento utilizado tratamentos casualizados parcelas subdivididas, no esquema fatorial 2 x 3 sete repetições. Os estudados foram duas variedades alface: Aurélia folha lisa Lucy Brown crespa cultivadas nos sem mulching, dupla face, preto na face superior branco inferior...
Mutations in genes coding for proteasome subunits and/or assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients CANDLE/PRAAS present mostly chronically type I interferon scores that emerge a consequence of increased proteotoxic stress by mechanisms are not fully understood. Here, we report on five unrelated...
O posicionamento de variedades adaptadas ao clima da região é importante para a padronização produtividade. Desta forma, o objetivo deste projeto realizar dois ensaios valor cultivo e uso com do programa UFV no município Cristalina-GO. experimento foi conduzido em locais Cristalina-GO nas safras 2022-2023. localizados Cristalina-GO, primeiro local Estação Experimental IF Goiano Campus Cristalina (latitude 16º 49' S longitude 47º 36' W) segundo na Fazenda São Geraldo 50' 48' W). delineamento...
Objective: To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody the following variables: demographic data, cumulative clinical laboratory manifestations, disease activity, damage mortality. Methods: A cross-sectional study was performed 27 Pediatric Rheumatology University centers, including 912 patients. The frequencies seven selected (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG...
Abstract Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as hyper inflammatory process with multiorgan involvement predominantly healthy children the weeks following mild or asymptomatic disease 2019 (COVID-19). However, host monogenic predisposing factors to MIS-C remain elusive. Methods Herein, we used whole exome sequencing (WES) on 16 Brazilian...
Objective To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood‐onset systemic lupus erythematosus (SLE) complicated by nephritis (LN), using consensus formation methodology. Methods Parameters influencing corticosteroid (CS) were identified (step 1). Data from children with proliferative LN used to generate patient profiles 2). Physicians rated changes in renal and extrarenal SLE activity between 2 consecutive visits proposed CS 3). The SSR was developed...
ABSTRACT Objective: To describe the current state of art in therapeutic administration botulinum toxin with indications, efficacy, and safety profile for children adolescents cerebral palsy. Data source: An integrative review was conducted. The MEDLINE/PubMed database searched twice within last decade using distinct terms, only studies written English language were included. study population limited to those aged 0–18 years. Articles that duplicates or lacked sufficient methodology...
<h3>Background</h3> To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). <h3>Objectives</h3> This study aims to compare the performance among American College of Rheumatology (ACR) 1997, Systemic Lupus International Collaborating Clinics (SLICC) and new European League Against Rheumatism (EULAR)/ACR criteria, in a cSLE cohort. <h3>Methods</h3> Data were retrospectively collected from medical charts cases controls with defined...
To evaluate if the 2019-European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) criteria at diagnosis childhood-onset systemic lupus erythematosus (cSLE) are associated with higher rates early damage scored by Systemic Lupus International Collaborating Clinics/American (SLICC/ACR) Damage Index (SDI).This retrospective multicenter study included 670 cSLE patients ≤5 years disease duration. All fulfilled both 2019-EULAR/ACR and 1997-ACR classification criteria. Total...
Objectives To identify associations between mortality in cSLE patients and their characteristics: clinical laboratory features, disease activity damage scores, treatment; to evaluate risk factors associated with cSLE; determine the most frequent causes of death this group patients. Methods We performed a multicenter retrospective cohort using data from 1,528 followed 27 pediatric rheumatology tertiary centers Brazil. Patients’ medical records were reviewed according standardized protocol,...
A Doença do Trato Urinário Inferior em Felinos (DTUIF) é uma condição complexa que reflete a interação entre anatomia única dos felinos e fatores ambientais, como o estresse.A urinária gatos, especialmente nos machos, caracterizada por uretra estreita longa, naturalmente aumenta risco de obstruções urinárias.Essa predisposição anatômica, combinada com capacidade gatos concentrar fortemente urina para conservar água (um traço evolutivo seus ancestrais viviam no deserto), pode facilitar...
Este relato aborda um caso de lesão medular em gato causada por projétil arma fogo, com foco na anatomia da coluna vertebral felina e no impacto do trauma.A dos gatos é uma estrutura complexa, adaptada para flexibilidade agilidade, composta vértebras que protegem a medula espinhal, essencial transmissão sinais entre o cérebro corpo.O estudo envolve dois anos, sofreu paralisia membros pélvicos disúria devido provocada projétil.A análise deste incidente destaca vulnerabilidade espinhal dentro...
To the Editors: We read, with great interest, a recent article on case fatality rate (CFR) of pediatric multisystem inflammatory syndrome in children (MIS-C) Brazil.1 Considering this, we share our findings from an observational multicenter study conducted Rio de Janeiro State, which challenges prevailing national trends. Brazil, estimated population 215.3 million inhabitants and ranked as sixth most populous country globally, exhibits stark socioeconomic inequalities disparities healthcare...