A5090446328- Plant Surface Properties and Treatments
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Insect and Arachnid Ecology and Behavior
- RNA modifications and cancer
- Polysaccharides and Plant Cell Walls
- Tuberculosis Research and Epidemiology
- Advanced Fiber Optic Sensors
- Inhalation and Respiratory Drug Delivery
- Plant Stress Responses and Tolerance
- Muscle Physiology and Disorders
- Plant Water Relations and Carbon Dynamics
- Galectins and Cancer Biology
- Analytical Chemistry and Sensors
- Ubiquitin and proteasome pathways
- Insect and Pesticide Research
- Telomeres, Telomerase, and Senescence
- Antimicrobial Peptides and Activities
- Inflammasome and immune disorders
- Gas Sensing Nanomaterials and Sensors
- Tree Root and Stability Studies
- Plant biochemistry and biosynthesis
Iowa State University
2016-2024
National Institute of Allergy and Infectious Diseases
2023-2024
National Institutes of Health
2023
Mayo Clinic
2022
Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice humans. Using a mouse model p21 overexpression (p21OE), we examined if mechanistically contributes to cellular senescence pathological features muscle. We show that induces several core properties muscle, including an altered transcriptome, DNA damage, mitochondrial dysfunction, senescence-associated secretory phenotype (SASP). Furthermore, p21OE exhibit...
Mutations in genes coding for proteasome subunits and/or assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients CANDLE/PRAAS present mostly chronically type I interferon scores that emerge a consequence of increased proteotoxic stress by mechanisms are not fully understood. Here, we report on five unrelated...
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented immuno-modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing normalizing the aberrant granuloma-associated vasculature, here we demonstrate that FDA-approved (bevacizumab losartan, respectively) can be repurposed...
Abstract Root hairs are tubular extensions of the epidermis. monogenic recessive maize mutant roothairless 6 (rth6 ) arrested after bulge formation during transition to tip growth and display a rough cell surface. BSR-Seq in combination with Seq-walking subsequent analyses four independently generated alleles established that rth6 encodes CSLD5 plasma membrane localized 129 kD D-type cellulose synthase eight transmembrane domains. Cellulose synthases required for biosynthesis cellulose, most...
Abstract The plant cuticle is a complex extracellular lipid barrier that has multiple protective functions. This study investigated deposition by integrating metabolomics and transcriptomics data gathered from six different maize seedling organs of four genotypes, the inbred lines B73 Mo17, their reciprocal hybrids. These datasets captured developmental transition heterotrophic skotomorphogenic growth to autotrophic photomorphogenic growth, highly vulnerable environmental stresses....
This paper reports on a simple method to track water transport inside the plant by using multiple graphene oxide (GO) based relative humidity sensors. The sensor was formed an adhesive polyimide film selectively coating GO layer top of gold interdigitated electrodes and subsequently peeling whole device structure off from pre-coated polydimethylsiloxane temporary layer. To allow easy installation at leaf plant, assembly fixture designed. present measurement provides information how moves...
Abstract The extraordinarily long stigmatic silks of corn ( Zea mays L.) are critical for grain production but the biology their growth and emergence from husk leaves has remained underexplored. Accordingly, gene expression was assayed inbreds ‘B73’ ‘Mo17’ across five contiguous silk sections. Half maize genes (∼20,000) expressed in silks, mostly spatiotemporally dynamic patterns. In particular, triggers strong differential ∼1,500 collectively enriched ontology terms associated with abiotic...
ABSTRACT The plant cuticle is a complex extracellular lipid barrier that provides protection from numerous environmental stressors and critical for normal organ development. In this study, we investigated deposition by integrating metabolomics transcriptomics data gathered six different maize seedling organs of four genotypes, the inbred lines B73 Mo17, their reciprocal hybrids. These datasets captured developmental transition heterotrophic skotomorphogenic growth to autotrophic...