A5036497380- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Immunodeficiency and Autoimmune Disorders
- Kawasaki Disease and Coronary Complications
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Osteomyelitis and Bone Disorders Research
- Physical Education and Gymnastics
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Atherosclerosis and Cardiovascular Diseases
- Leprosy Research and Treatment
- Otitis Media and Relapsing Polychondritis
- Food, Nutrition, and Cultural Practices
- Academic Research in Diverse Fields
- COVID-19 Clinical Research Studies
- Marriage and Sexual Relationships
- Spondyloarthritis Studies and Treatments
- Childhood Cancer Survivors' Quality of Life
Universidade Federal do Rio de Janeiro
2011-2024
KPMG (United Kingdom)
2011-2019
Faculdade Brasil
2018
Fundação Oswaldo Cruz
2010
To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). This study aims to compare the performance among American College of Rheumatology (ACR) 1997, Systemic Lupus International Collaborating Clinics (SLICC) and new European League Against Rheumatism (EULAR)/ACR criteria, in a cSLE cohort. We conducted medical chart review cases controls with defined rheumatic diseases, both ANA positive, establish each ACR1997, SLICC EULAR/ACR...
Mutations in genes coding for proteasome subunits and/or assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients CANDLE/PRAAS present mostly chronically type I interferon scores that emerge a consequence of increased proteotoxic stress by mechanisms are not fully understood. Here, we report on five unrelated...
Abstract Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as hyper inflammatory process with multiorgan involvement predominantly healthy children the weeks following mild or asymptomatic disease 2019 (COVID-19). However, host monogenic predisposing factors to MIS-C remain elusive. Methods Herein, we used whole exome sequencing (WES) on 16 Brazilian...
Angiotensin-converting enzyme (ACE) downregulates the activity of bradykinin, a potent proinflammatory and immunostimulatory peptide liberated from an internal portion kininogens. Here, we asked whether periodontitis is worsened in patients under antihypertensive treatment with ACE inhibitors.Periodontal parameters were recorded 30 individuals taking inhibitors (case) 35 non-ACE inhibitor medication (control). Data analyzed by nonparametric parametric statistical tests.Most sociodemographic...
OBJETIVOS: Descrever uma população de crianças com diagnóstico doença Kawasaki (DK) atendida em centros reumatologia pediátrica do Rio Janeiro. Analisar o período atraso no e início tratamento, devido à dificuldade distinguir DK outras doenças febris comuns da infância; impacto deste na frequência sequelas coronarianas. MÉTODOS: Os dados analisados incluíram: nome, sexo, idade, data inicio dos sintomas admissão serviço especializado, sintomatologia, evolução clínica, uso Imunoglobulina...
Background and Objective Simple Measure of the Impact Lupus Erythematosus in Youngsters (SMILEY) is a health‐related quality life (HRQOL) assessment tool for pediatric systemic lupus erythematosus (SLE), which has been translated into Portuguese Brazil. We are reporting preliminary data on cross‐cultural validation reliability SMILEY (Brazil). Methods In this multi‐center cross‐sectional study, Brazilian children adolescents 5–18 years age with SLE parents participated. Children completed...
Rheumatic diseases in children are associated with significant morbidity andpoor health-related quality of life (HRQOL). There is no health-relatedquality (HRQOL) scale available specifically for lesscommon rheumatic diseases. These share several features withsystemic lupus erythematosus (SLE) such as their chronic episodic nature,multi-systemic involvement, and the need immunosuppressive medications.HRQOL developed pediatric SLE will likely be applicable tochildren systemic inflammatory We...
To the Editors: We read, with great interest, a recent article on case fatality rate (CFR) of pediatric multisystem inflammatory syndrome in children (MIS-C) Brazil.1 Considering this, we share our findings from an observational multicenter study conducted Rio de Janeiro State, which challenges prevailing national trends. Brazil, estimated population 215.3 million inhabitants and ranked as sixth most populous country globally, exhibits stark socioeconomic inequalities disparities healthcare...
OBJETIVO: Avaliar a freqüência e gravidade dos efeitos adversos durante infusão de infliximabe. MATERIAL E MÉTODOS: Avaliação retrospectiva prontuários 58 pacientes acompanhados em cinco serviços reumatologia pediátrica. Todos apresentavam doença refratária ou eram intolerantes ao uso uma mais drogas modificadoras receberam infusões A análise estatística foi descritiva, levando-se conta o tipo adversos, assim como sua relação com número infusões, dose infliximabe indicação. RESULTADOS: média...
ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, response therapy in a large population. Methods: This is cross-sectional observational study of Latin American registry using designed web system for data storage, collected between 2015 2018. Any altered findings during follow-up were recorded. The forms translated into Portuguese Spanish, including demographic, clinical, laboratory, genetic treatment characteristics. Results: We included...
Methotrexate is the most used DMARD drug in treatment of juvenile idiopathic arthritis and its efficacy has been demonstrated for more than 20 years. The usual dose 10 to 15mg/m2/week. It a safe well-tolerated by children common side effects are gastrointestinal, hematologic liver toxicity.
To evaluate the importance attributed to tonsillitis by guardians and their level of knowledge about disease, correlating management with schooling socioeconomic profiles.A quantitative, descriptive observational cross-sectional study involving students aged 5 17 years from state-owned private schools. A questionnaire was applied on rheumatic fever, addressing demographic data.A total 323 were included, predominantly females (61.3%), schools (77.1%), a mean age 9.7±0.3 years. Among...