A5034207260- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Vasculitis and related conditions
- COVID-19 and Mental Health
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Kawasaki Disease and Coronary Complications
- Childhood Cancer Survivors' Quality of Life
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Healthcare professionals’ stress and burnout
- Genetic Syndromes and Imprinting
- Viral Infections and Immunology Research
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- T-cell and B-cell Immunology
- Osteomyelitis and Bone Disorders Research
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Complement system in diseases
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2025
Universidade de São Paulo
2015-2024
Weatherford College
2024
Garrahan Hospital
2021
Universidade Federal de São Paulo
2013-2021
Center for Rheumatology
2021
Instituto do Coração
2019
Children’s Institute
2015
To evaluate demographic data and clinical laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); B, school (≥6 to <12 C, adolescent (≥12 <18 years).This was a Brazilian multicenter cohort retrospective study 10 pediatric rheumatology centers, including 847 SLE patients.Patients were divided into groups: A with 39 patients (4%), B 395 (47%), C 413 (49%). Of (8%) ages <2 years, 4 (10%) ≥2 <3 32...
To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19).
Objective: To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody the following variables: demographic data, cumulative clinical laboratory manifestations, disease activity, damage mortality. Methods: A cross-sectional study was performed 27 Pediatric Rheumatology University centers, including 912 patients. The frequencies seven selected (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG...
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Objective. We assessed the orofacial involvement in JDM, and evaluated possible association of gingival mandibular mobility alterations with demographic data, periodontal indices, clinical features, muscle enzyme levels, JDM scores treatment. Methods. Twenty-six patients were studied compared 22 healthy controls. Orofacial evaluation included dental assessment, function salivary flow. Results. The mean current age was similar controls (P > 0.05). A unique alteration characterized by...
Objectives: The main purpose of the study was to investigate left ventricular (LV) subclinical systolic and diastolic dysfunction in childhood-onset systemic lupus erythematosus (c-SLE) patients using two-dimensional speckle-tracking (2DST) echocardiography. We also interrogated possible correlations between impairment myocardial deformation SLE Disease Activity Index 2000 (SLEDAI-2K), as well presence traditional disease-related cardiovascular risk factors (CRFs).Method: A total 50...
To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during coronavirus disease 2019 (COVID-19) pandemic.
Objectives Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering interpretation clinical and laboratorial associations. Therefore, objective multicenter cohort study was evaluate demographic, clinical/laboratorial features, disease damage score cSLE patients with without presence anti-P antibody....
To characterize scrotal involvement in children and adolescents with IgA vasculitis.A cross-sectional retrospective study included 296 vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males assessed by demographic/clinical/laboratory treatments. Scrotal was defined the presence of edema and/or pain/tenderness physical examination testicular Doppler ultrasound abnormalities.Scrotal observed 28/150 (19%) patients. This complication evidenced at diagnosis 27/28 (96%). Acute...
To evaluate alcohol, smoking and/or illicit drug use, and history of bullying in adolescent childhood-onset systemic lupus erythematosus healthy controls.174 adolescents with pediatric rheumatic diseases were selected. All the 34 patients 35 controls participated this study. A cross-sectional study included demographic/anthropometric data puberty markers assessments; structured questionnaire CRAFFT screening interview.McNemar tests indicated an excellent test-retest reliability (p=1.0). The...
To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis patients with JIA receiving TNF blockers.This was a retrospective cohort that included eligible to anti-TNF therapy. Patients were screened for LTBI prior using tuberculin skin test (TST), chest X-ray history exposure TB. Subjects regularly followed at 2-month intervals.Sixty-nine current age 17.4±5.8 years, mean disease duration 5.0±4.9 years included....
Abstract Background Exercise has been suggested to prevent deterioration of health-related quality life (HRQL) and overall health in pediatric rheumatologic diseases during the COVID-19 pandemic. Herein we describe effects a 12-week, home-based, exercise program on among quarantined patients with juvenile dermatomyositis (JDM). Method This prospective, quasi-experimental, mixed methods (qualitative quantitative) study was conducted between July December 2020, most restricted period pandemic...
Avaliar, em um país endêmico, a eficácia longo prazo do rastreamento à procura de infecção latente por tuberculose (ILTB) e profilaxia primária pacientes com AIJ uso bloqueadores TNF. Trata‐se uma coorte retrospectiva que incluiu elegíveis para terapia anti‐TNF. Os foram rastreados ILTB previamente ao anti‐TNF meio teste tuberculínico (TT), radiografia tórax história exposição TB. indivíduos acompanhados regularmente intervalos dois meses. Incluíram‐se 69 idade atual 17,4 ± 5,8 anos, média...
Cervical adenitis >1.5cm in diameter is the less frequently observed criteria patients with Kawasaki disease and it usually found association other symptoms during acute phase. Moreover, finding of fever lymphadenitis intense local signs inflammation phlegmon rarely seen as initial manifestation disease. We report case a 7-year-old boy who had cervical adjacent cellulitis mimicking bacterial first presentation The patient fever, cellulitis, severe headache. Cefadroxil was prescribed based on...
Abstract Objective: to assess mental health issues in pediatric nurses during coronavirus pandemic 2019. Method: cross-sectional study was conducted with at the Instituto da Criança e do Adolescente based on online self-rated survey about clinical practice and impact COVID-19 pandemic. Validated self-reported scales for anxiety, depression burnout were used assessing these professionals. Results: 107/298 (36%) answered, 90% female, median age 41(23-64) years, 68% worked adolescents, 66%...
To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents immunocompromising diseases.A cross-sectional study included 343 diseases 108 healthy adolescents. Online questionnaires were answered including socio-demographic data self-rated healthcare routine during validated surveys: Strengths Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric of Life Inventory 4.0 (PedsQL4.0).The...