A5010803779- Sarcoma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Osteomyelitis and Bone Disorders Research
- Hematological disorders and diagnostics
- Streptococcal Infections and Treatments
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Bone fractures and treatments
- Neuroblastoma Research and Treatments
- Neurogenetic and Muscular Disorders Research
- Testicular diseases and treatments
- Hormonal and reproductive studies
- Vascular Tumors and Angiosarcomas
- Elbow and Forearm Trauma Treatment
- Musculoskeletal Disorders and Rehabilitation
- Antibiotic Use and Resistance
- Urinary Bladder and Prostate Research
- Bone health and treatments
- Molecular Biology Techniques and Applications
- Pain Management and Treatment
- Sexual function and dysfunction studies
- Scoliosis diagnosis and treatment
- Renal and related cancers
University of Colorado Denver
2015-2025
Children's Hospital Colorado
2016-2025
Orthopedic Institute
2025
University of Colorado Anschutz Medical Campus
2023-2025
University of Colorado Boulder
2024
Yahoo (United Kingdom)
2024
University of Miami
2018
King's College Hospital
2004
Acute pediatric musculoskeletal infections are common, leading to significant use of resources and antimicrobial exposure. In order decrease variability improve the quality care, Children's Hospital Colorado implemented a clinical care guideline (CCG) for these infections. The purpose this study is evaluate resource outcomes PRE POST CCG. Retrospective chart review evaluated patients admitted large quaternary referral center (CHCO) diagnosed with acute osteomyelitis, septic arthritis,...
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Abstract Purpose: Ewing sarcoma (EwS) is the second most common bone cancer in children, accounting for 2% of pediatric diagnoses. Patients who present with metastatic disease at time diagnosis have a dismal prognosis, compared to >70% 5-year survival those localized disease. Novel therapeutic approaches that can impact are desperately needed, as well deeper understanding heterogeneity EwS tumors. Experimental Design: Here, we utilized single cell RNA-sequencing characterize...
Abstract Ewing sarcoma is the second most common bone cancer in children, accounting for 2% of pediatric diagnoses. Patients who present with metastatic disease at time diagnosis have a dismal prognosis, compared to >70% 5-year survival those localized disease. Here, we utilized single cell RNA-sequencing characterize transcriptional landscape primary tumors and surrounding tumor microenvironment (TME). Copy-number analysis identified subclonal evolution within patients prior treatment....
Increased sympathetic tone may cause an equivocal response to a prostaglandin E1 (PGE1) penile Doppler ultrasound (US) examination interpreted as venous leak. We evaluated the US parameters and erectile addition of phentolamine PGE1 ascertain whether would abolish suboptimal response. 32 patients (median age 29 years, range 17-70 years) with either previous pattern leakage or clinical suspicion venogenic impotence, underwent after total dose 20 microg PGE1. Peak systolic velocity (PSV), end...
We present a surgical technique for chest wall reconstruction using custom-designed titanium implants developed two female patients to provide both symmetry and adequate stability staged breast reconstruction.A retrospective review was performed adolescent with large defects who underwent the described technique. The etiology of deficiency secondary Poland's syndrome in one patient, resection osteosarcoma other patient. For each fine-cut computed tomography scan obtained assist implant...
➢ Patients with congenital pseudarthrosis of the tibia do not have a normal tibia. In such patients, entire is abnormal (even outside established site); bone does healing response to injury or osteotomy, and proximal growth plate typically has an inclination. Operative attempts promote union at site (intramedullary nailing bone-grafting, Ilizarov technique, microvascular free fibular transfer) fail address as whole. We must critically evaluate treatment outcomes for patients tibia;...
1. Nathan Donaldson, DO* 2. Julia Sanders, MD* 3. Jason Child, PharmD† 4. Sarah Parker, MD‡ 1. *Division of Orthopedic Surgery and 2. ‡Division Infectious Diseases, Department Pediatrics, University Colorado Denver School Medicine, Aurora, CO 3. †Department Pharmacy, Children’s Hospital Colorado, CO * Abbreviations: ADE: : adverse drug event CRMO: chronic recurrent multifocal osteomyelitis CRP: C-reactive protein CT: computed tomography ESR: erythrocyte sedimentation rate MRI:...
BACKGROUND: Acute hematogenous musculoskeletal infections are a common cause of hospitalization in children. A locally developed clinical care guideline (CCG) for acute was implemented at our quaternary pediatric hospital July 2012. The purpose this study to evaluate the long-term sustainability previously described improvements after CCG implementation. METHODS: Clinical outcomes children hospitalized with Children’s Hospital Colorado from June 2009 through September 2018 were...
Abstract Background High-dose-rate brachytherapy (HDR-BT) and external-beam radiation therapy (EBRT) are two modalities used in the treatment of soft tissue sarcoma. Previous work at our institution showed early complications outcomes for patients treated with HDR-BT, EBRT, or a combination both modalities. As general indications each these approaches to differ, it is important evaluate use an algorithmic way, reflecting how they contemporary practice sites that treatments. Question/purposes...
Background: Identifying the causative pathogen for acute hematogenous musculoskeletal infections (MSKIs) allows directed antimicrobial therapy and diagnostic confidence. However, 20% to 50% of children with MSKIs remain culture negative. The objective this study was compare characteristics negative MSKI patients those where a is identified. Methods: Electronic medical records admitted between July 2014 September 2018 single quaternary care pediatric hospital were retrospectively reviewed....
Metastatic central nervous system (CNS) involvement is rare in pediatric primary extracranial Ewing sarcoma (ES). We describe the incidence and course of 6 patients with ES who developed metastatic CNS lesions treated at a single institution. The median time to disease detection was 16.3 months (10.0-28.3 months). Event-free overall survival after were 1.9 (0.4 10.3 months) 4.6 (1.1 50.9 months), respectively. One patient alive analysis. Clinical status ability obtain control should be...
The field of vascular anomalies has seen a rapid paradigm shift from descriptive to molecular diagnoses, with DNA-based next-generation sequencing becoming standard practice in the workup and characterization lesions. RNA-based panels for fusion transcripts have been less utilized anomalies. We report recurrent, infiltrative prevertebral tumor negative known somatic variants but positive an Ewing sarcoma breakpoint region 1::nuclear factor activated T-cells cytoplasmic 2 transcript. This...
Background: Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder of bone, typically arising adjacent to the physes long bones but also seen throughout skeleton. For patients with spinal involvement, CRMO lesions can cause compression deformities a range severity from minimal anterior wedging circumferential height loss, known as vertebra plana. This study examines large cohort determine prevalence spine involvement and vertebral deformity. Methods: retrospective...
<title>Abstract</title> <bold>Background</bold> NSAIDs are commonly used as first line therapy in chronic nonbacterial osteomyelitis (CNO) but not effective for all patients. The objective of this study was to identify clinical variables associated with NSAID monotherapy response versus requiring second-line medication a single-center cohort patients CNO.<bold>Methods</bold> charts children CNO who attended clinic at quaternary care center between 1/1/05 and 7/31/21 were retrospectively...
Solid organ transplant recipients are at increased risk of malignancy. Pediatric particularly have a potentially higher given the young age immunosuppression initiation. Posttransplant malignancies main cause death in 5%-16% liver transplantation patients. The frequency de novo pediatric has been reported to be 13%. Synovial sarcoma is malignant mesenchymal neoplasm that not previously after transplantation. We report case an adolescent recipient who was diagnosed with synovial 14 years
Metastatic central nervous system (CNS) involvement is rare in pediatric primary extracranial Ewing sarcoma (ES). We describe the incidence and course of six patients with ES who developed metastatic CNS lesions treated at a single institution. Median time to disease detection was 16.3 months (10.0-28.3 months). Event free overall survival after were 1.9 (0.4-10.3 months) 4.6 (1.1-50.9 months), respectively. One patient alive analysis. Clinical status ability obtain control should be...
Case: A 19-year-old adolescent with Kniest dysplasia was incidentally found to have osteosarcoma of the proximal aspect humerus after having a chest radiograph for evaluation an upper respiratory infection. He underwent chemotherapy and resection tumor, there no evidence metastasis at 16-month follow-up. Conclusion: Patients osteochondrodysplasias often multiple orthopaedic symptoms. Changes in chronic pain symptoms should be investigated rule out insidious secondary causes musculoskeletal...