Matthew L. Basiaga
A5048707971- Genomics and Rare Diseases
- Autoimmune and Inflammatory Disorders Research
- Genomic variations and chromosomal abnormalities
- Salivary Gland Disorders and Functions
- Orthopedic Infections and Treatments
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Blood groups and transfusion
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- BRCA gene mutations in cancer
- Disaster Response and Management
- Musculoskeletal Disorders and Rehabilitation
- Viral-associated cancers and disorders
- Disaster Management and Resilience
- Dermatological and COVID-19 studies
- Histiocytic Disorders and Treatments
- Streptococcal Infections and Treatments
Mayo Clinic in Florida
2020-2025
Mayo Clinic
2019-2025
Mayo Clinic in Arizona
2020-2024
WinnMed
2019-2023
University of North Carolina at Chapel Hill
2022
University of Alabama at Birmingham
2022
Durham VA Medical Center
2022
Emory University
2022
American College of Rheumatology
2022
University of California, San Francisco
2021
Abstract Objective Sjögren syndrome in children is a poorly understood autoimmune disease. We aimed to describe the clinical and diagnostic features of diagnosed with explore how 2016 ACR/EULAR classification criteria apply this population. Methods An international workgroup retrospectively collected cases under 18 years age from 23 centres across eight nations. analysed patterns symptoms, workup, applied criteria. Results identified 300 syndrome. The majority patients n = 232 (77%) did not...
Studies evaluating treatment responses for chronic nonbacterial osteomyelitis (CNO) are lacking. We aimed to measure and compare response rates of medical treatments, time treatments among patients with CNO the mandible, describe bacterial contamination from biopsy.We conducted a retrospective chart review all diagnosed mandible between 2003 2017 extracted demographic, clinical, laboratory, imaging surgical data. Detailed medication use medications were recorded. The primary outcome was...
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To characterize the incidence and prevalence of childhood-onset systemic lupus erythematosus (SLE), to estimate proportion patients who are diagnosed with SLE during childhood.
Sjögren disease in children and adolescents (pedSD) presents differently than adult disease. Diagnosis classification are controversial, optimal treatment is unknown outcomes poorly understood. Here, we describe the current perspectives of pediatric rheumatologists on diagnosis, treatment, pedSD.A voluntary, 17-question survey was distributed to providers Childhood Arthritis Rheumatology Research Alliance and/or American College Sjögren's Study Group at 2020 Convergence Virtual Conference....
Abstract Background In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD an estimated 30 million Americans. A significant portion of has underlying genetic cause; however, this may go undiagnosed. To better serve these patients, Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD) was created under auspices Center Individualized Medicine (CIM) aiming to integrate genomics into subspecialty practice including...
We report a 6-year-old man with chronic severe recalcitrant bilateral anterior uveitis and remote history of hemophagocytic lymphocytic histiocytosis secondary to Epstein-Barr virus infection. The patient was treated for idiopathic after an initial extensive evaluation failed reveal specific diagnosis. achieve sustained inactive disease multiple monotherapies including topical glucocorticoid, methotrexate, infliximab, mycophenolate mofeti, cyclosporine. Disease control finally attained...
Antimicrobial prophylaxis is indicated to prevent Pneumocystis jirovecii pneumonia (PJP) in profoundly immunosuppressed children. The incidence of PJP infection children with chronic glucocorticoid exposure unknown, and has been associated adverse events. We hypothesized that rare without human immunodeficiency virus (HIV)/acquired syndrome (AIDS), cancer, or a transplant history who are using glucocorticoids those exposed more likely experience cutaneous hypersensitivity reaction...
Minimal data are available regarding the postdischarge treatment of multisystem inflammatory syndrome in children (MIS-C).To evaluate clinical characteristics associated with duration glucocorticoid use and assess course, laboratory test result trajectories, adverse events a multicenter cohort MIS-C.This retrospective study included patients MIS-C hospitalized severe illness followed up for 3 months an ambulatory setting. Patients younger than 21 years who were admitted between May 15, 2020,...
International multidisciplinary collaboration and patient partnerships are essential to prioritize address knowledge gaps in cSjD. This international collaborative workgroup recommends large prospective cohort studies tackle
Abstract Background Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment modifying anti-rheumatic drugs (DMARDs). IAS offer an opportunity to recapture control and avoid exposure side effects from immunosuppression. We examined cohort patients treated after report the probability restarting within 12 months. Methods analyzed Childhood Arthritis...
The aim of this study was to determine the compliance colleges and universities in United States with nationally published guidelines by Federal Emergency Management Agency U.S. Department Education for emergency disaster preparedness at institutions higher education.A questionnaire electronically distributed director security personnel 1167 between January 2010 August 2011.Two hundred twenty-three questionnaires were available analysis. Although 96% had an official plan, 10% do not practice...
The impact of social determinants health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation treatment for pJIA important to prevent disease morbidity; however, a potential barrier early pJIAs delayed presentation pediatric rheumatologist. We examined the community poverty level, key determinant health, time from patient reported symptom onset first rheumatology visit among patients enrolled in Childhood Arthritis and Rheumatology...
Chronic nonbacterial osteomyelitis (CNO) is an uncommon autoinflammatory disorder. Significant effort has recently been spent to better define and treat this disorder including development of consensus treatment protocols, validate disease activity tools, refining classification criteria. However, the underlying immunopathogenesis remains elusive. In report, we describe simultaneous onset CNO in siblings. A pathogenic gene mutation was not identified, these sisters lacked a similar biomarker...
Childhood Sjögren disease (cSjD) is a rare disease. There are no widely accepted diagnostic or classification criteria for cSjD. To fill this gap, members from CARRA Sjogren Workgroup and the International cSjD created clinical algorithm. This study evaluates accuracy of algorithm using an international cohort participants with clinician diagnosed
Toe walking is a previously unreported presentation of systemic lupus erythematosus (SLE). We describe patient who presented with profound multisystem involvement that was preceded by one month toe and multiple flexion contractures without arthritis. Her now under control after aggressive therapy, yet she continues to struggle tendinopathy despite continued physical occupational therapy. Lupus should be considered in the appropriate clinical context children have new-onset due tight tendons.
Abstract Background We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. Methods The CARRA Registry is a convenience cohort of with paediatric onset rheumatic diseases, including JIA. JIA treated ETN for whom month year initiation were available included. Patterns methotrexate (MTX) categorized as follows: combination therapy (ETN MTX started concurrently), step-up...
To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with JIA.JIA Childhood Rheumatology Research Alliance Registry enrolled within 3 months diagnosis from 15 June 2015 to 6 December 2017 at least two cJADAS10 scores 24 follow-up were included. Latent growth curve models analysed; a combination Bayesian information criterion, posterior probabilities judgement was used select model...