A5020761427- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Mechanical Circulatory Support Devices
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Neonatal Respiratory Health Research
- Polyomavirus and related diseases
- Muscle and Compartmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- T-cell and B-cell Immunology
- BRCA gene mutations in cancer
- Family and Patient Care in Intensive Care Units
- Organ Transplantation Techniques and Outcomes
- Organ and Tissue Transplantation Research
- Teratomas and Epidermoid Cysts
- Genetics and Neurodevelopmental Disorders
- Mast cells and histamine
Mayo Clinic
2023-2024
James Madison University
2024
WinnMed
2023
University of Minnesota
2023
University College Dublin
2022
Western University
2021
Georgetown University
2021
Mesoblast (United States)
2015-2021
Minnesota Medical Association
2021
The Ohio State University
2020-2021
Background— Cardiac transplantation vasculopathy is the leading cause of late death in heart recipients. Rapamycin an immunosuppressant drug with potent antiproliferative and antimigratory effects. We investigated whether rapamycin could prevent progression graft 46 patients (age, 54±10 years; 4.3±2.3 years after transplantation) severe disease. Methods Results— At annual cardiac catheterization, were randomly assigned to treatment (n=22) versus continued current immunosuppression (n=24)....
Alloantigen-activated T cells express the high-affinity interleukin-2 receptor. Specific blockade of this receptor with human IgG1 monoclonal antibody daclizumab may prevent rejection allografts after cardiac transplantation without inducing global immunosuppression.
A network of tubular lysosomes extends through the cytoplasm J774.2 macrophages and phorbol ester-treated mouse peritoneal macrophages. The presence this is dependent upon integrity cytoplasmic microtubules correlates with high cellular rates accumulation Lucifer Yellow (LY), a marker fluid phase pinocytosis. We tested hypothesis that efficiency LY transfer between pinosomal lysosomal compartments increased in by asking how conditions deplete lysosome affect pinocytic LY. Tubular were...
Clinical outcomes in children with steroid-refractory acute graft-versus-host disease (SR-aGVHD) are generally poor, a high mortality rate and limited therapeutic options. Here we report our updated investigational experience mesenchymal stromal cell (MSC) therapy remestemcel-L multicenter expanded access protocol (ClinicalTrials.gov identifier NCT00759018) 241 aGVHD who failed to respond steroids or without other secondary tertiary immunosuppressive therapies. A total of grade B-D SR-aGVHD...
Recipients of left ventricular assist devices (LVADs) develop prominent B-cell hyperreactivity. We investigated the influence anti-HLA antibodies on waiting time to cardiac transplantation in LVAD recipients and compared effects 2 immunomodulatory regimens serum reactivity.Fifty-five previously nonsensitized a TCI device implanted between 1990 1996 were studied. Patients with received monthly courses either intravenous immunoglobulin (IVIg) or plasmapheresis, conjunction cyclophosphamide....
The proportion of cardiac transplant recipients with preexisting sensitization to HLA alloantigens has been increasing. Sensitization prolongs duration obtaining a donor and predicts poorer long-term allograft survival because increased risk cellular rejections. We investigated the effect cyclophosphamide pulse therapy in sensitized recipients.Pretransplant posttransplant outcomes were compared between 88 at for 26 treated intravenous together immune globulin before as part...
Background Addressing mental health illnesses among the college student population is pressing since they are associated with a decline in academic performance.
Transplant-related coronary-artery disease (TCAD) develops frequently in cardiac-allograft recipients, and limits long-term survival. We examined the relation between this disorder cumulative frequency of high-grade rejection, investigated whether concomitant use three immunological factors at time a low-grade endomyocardial biopsy can predict progression to rejection.We annual rejection TCAD 198 recipients cardiac transplantation 1992 1996 by means Kaplan-Meier actuarial life-tables....
Most humoral rejection (HR) episodes occur early after cardiac transplantation and are associated with hemodynamic compromise poor prognosis. Late cases of HR (>6 months transplant) have been reported. We examined the differences in clinical characteristics outcomes patients presenting (<6 months) late transplant periods.A retrospective chart review was performed all at a single large center from January 1, 1995 to March 2006.A total 37 adult transplants had biopsy-proven HR; 13 24 mean 5 yr...
Bronchiolitis obliterans organizing pneumonia (BOOP) presents with fever, dyspnoea, pleuritic chest pain and hypoxia. The diagnosis can be made from radiological appearances on radiograph CT scan correlated histological findings following biopsy. We present a 52-year-old gentleman undergoing treatment for high grade non-Hodgkin's lymphoma who developed respiratory symptoms during chemotherapy. BOOP was diagnosed he responded well to oral prednisolone. cause of is often not certain. However,...
Abstract Background In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD an estimated 30 million Americans. A significant portion of has underlying genetic cause; however, this may go undiagnosed. To better serve these patients, Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD) was created under auspices Center Individualized Medicine (CIM) aiming to integrate genomics into subspecialty practice including...
Activation of T cells induces immunoglobulin (Ig)M-to-IgG B-cell isotype switching via costimulatory regulatory pathways. Because rejection transplanted organs is preceded by alloantigen-dependent T-cell activation, we investigated whether could predict acute cellular and the subsequent development transplantation-related coronary artery disease (TCAD) in cardiac transplant recipients.Among 267 nonsensitized heart recipients, from IgM to IgG anti-human leukocyte antigens (HLA) antibodies...
Background —Recipients of left ventricular assist devices (LVADs) develop prominent B-cell hyperreactivity. We investigated the influence anti-HLA antibodies on waiting time to cardiac transplantation in LVAD recipients and compared effects 2 immunomodulatory regimens serum reactivity. Methods Results —Fifty-five previously nonsensitized a TCI device implanted between 1990 1996 were studied. Patients with received monthly courses either intravenous immunoglobulin (IVIg) or plasmapheresis,...
Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS patients suffer mainly from deficiencies CO2 and/or O2 respiratory chemoreflex, whereas other present with full apnea shortly after birth. Our goal was to identify neuropathological mechanisms of apneic presentations CCHS. In developing murine neuroepithelium, Phox2b is expressed three discrete progenitor domains across...
Multisystem inflammatory syndrome in children (MIS-C) is a serious postinfectious immune dysregulation associated with coronavirus disease 2019 that may present severe and life-threatening cardiovascular dysfunction, hemodynamic instability, shock, multisystem organ failure. Optimal treatment unknown. Current standard of care consists nonspecific anti-inflammatory antithrombotic therapies. Interventions target MIS-C's distinctive clinical features immunophenotype are indicated....