Carolyn R. Rohrer Vitek
A5006580989- Pharmacogenetics and Drug Metabolism
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Ethics in Clinical Research
- Pharmaceutical studies and practices
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Health Sciences Research and Education
- Telomeres, Telomerase, and Senescence
- Pharmaceutical Practices and Patient Outcomes
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Biomedical Text Mining and Ontologies
- Renal and related cancers
- Statistical Methods in Clinical Trials
- Clinical Reasoning and Diagnostic Skills
- Simulation-Based Education in Healthcare
- Medication Adherence and Compliance
- Innovations in Medical Education
- Treatment of Major Depression
- Computational Drug Discovery Methods
- Biomedical and Engineering Education
- Electronic Health Records Systems
- Drug Transport and Resistance Mechanisms
- Body Composition Measurement Techniques
Mayo Clinic
2015-2024
WinnMed
2023
Centre for Individualised Infection Medicine
2014
Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing clinical decision support into settings. Recognizing importance of informed prescribers, a variety strategies were used incorporate provider education implementation. Education experiences with pharmacogenomics are described context each organization's prior involvement, including scope scale implementation specific their projects. We describe common...
A number of barriers exist for adoption pharmacogenomics into practice. Physicians, pharmacists, and nurses report limited knowledge about its use in patient care. Lack education curricula as part professional schools or postgraduate training programs has been reported a potential cause. Understanding is further complicated by complex nonstandard lexicon, medication guidelines, rapidly changing evidence, insufficient awareness test availability utility.
Summary To understand opinions and perceptions on the state of information resources specifically targeted to genomics, approaches delivery in clinical practice. We conducted a survey genomic content use its from representatives across eight institutions electronic Medical Records Genomics (eMERGE) network two Clinical Sequencing Exploratory Research (CSER) consortium 2014. Eleven responses representing distinct projects ten sites showed heterogeneity how is being delivered, with...
The development, implementation, and evaluation of a pharmacogenomics education program for pharmacists in large, integrated multicampus health system are described.Pharmacogenomics has been described as tailoring medications to each patient's unique genetic sequence with the goals minimizing harmful effects optimizing therapeutic effects. Pharmacists uniquely trained lead implementation clinical care. After assessment pharmacists' comfort pharmacogenomics, different approaches were explored...
Personalized medicine offers the promise of better diagnoses, targeted therapies and individualized treatment plans. Pharmacogenomics is an integral component personalized medicine; it aids in prediction individual's response to medications. Despite growing public acceptance emerging clinical evidence, this rapidly expanding field slow be adopted utilized by healthcare providers, although many believe that they should knowledgeable able apply pharmacogenomics practice. Institutional...
To assess impact and value of using clinical decision support (CDS) to drive providers toward online pharmacogenomics education.CDS was used target prescribers codeine/tramadol, send an educational email, display alert/inbox provide links resource. Providers were surveyed impact.Of the methods providers, email more effective (7.2%). Survey response rate 29.2% (n = 528/1817). Of respondents, 57.4% reported opening 27.1% accessed those accessing resource, 89% found it useful learned something...
Abstract Background In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD an estimated 30 million Americans. A significant portion of has underlying genetic cause; however, this may go undiagnosed. To better serve these patients, Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD) was created under auspices Center Individualized Medicine (CIM) aiming to integrate genomics into subspecialty practice including...
Pharmacogenomics (PGx) holds potential to improve patient treatment; yet, effective educational materials are limited.
Aim: To determine if differences in self-reported pharmacogenomics knowledge, skills and perceptions exist between internal medicine residents attending physicians. Materials & methods: Forty-six 54 physicians completed surveys. Thirteen participated focus groups to explore themes emerging from the Results: Resident reported a greater amount of training compared with (48 vs 13%, p < 0.00012). No were found perceptions. Conclusion: Both expressed was relevant their current clinical practice;...
Abstract Background Though next-generation sequencing (NGS) tests like exome (ES), genome (GS), and panels derived from data (EGBP) are effective for rare diseases, the ideal diagnostic approach is debated. Limited research has explored reanalyzing raw ES GS post-negative EGBP results diagnostics. Results: We analyzed complete ES/GS Mayo Clinic's Program Rare Undiagnosed Diseases (PRaUD) patients to assess whether supplementary findings could augment yield. 80 (59 adults) 20 (10 adults),...
The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use clinical decision support has the potential to prevent adverse effects from those drugs metabolized this enzyme. Our initial findings after implementation alerts integrated in electronic health records suggest high feasibility, but also identify important challenges.
Context.— Systems-based practice (SBP) is 1 of 6 core competencies required in all resident training programs accredited by the Accreditation Council for Graduate Medical Education. Reliable methods assessing competency SBP have not been described medical literature. Objective.— To develop and validate an analytic grading rubric to assess pathology residents' analyses problems clinical chemistry. Design.— Residents were assigned project based upon unmet needs chemistry laboratories. Using...