A5091104216- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Vitamin D Research Studies
- Eating Disorders and Behaviors
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Birth, Development, and Health
- Ophthalmology and Eye Disorders
- Diet and metabolism studies
- Health and Lifestyle Studies
- Bariatric Surgery and Outcomes
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Thyroid Disorders and Treatments
- Child and Adolescent Health
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacology and Obesity Treatment
- Mobile Health and mHealth Applications
- Legal and Policy Issues
- Neuroendocrine Tumor Research Advances
Mayo Clinic in Florida
2015-2025
New York Academy of Sciences
2017-2024
WinnMed
2013-2024
Mayo Clinic
2015-2024
Mayo Clinic in Arizona
2013-2024
Hudson Institute
2017-2024
John Wiley & Sons (Germany)
2022-2024
Moss Landing Marine Laboratories
2022-2024
Middle East Institute
2024
Liechtenstein Institute
2024
Graves' ophthalmopathy (GO) is characterized by expanded volume of the orbital tissues associated with elevated serum levels TSH receptor (TSHR) autoantibodies. Because previous studies have demonstrated evidence adipogenesis within GO orbit, we sought to determine whether M22, a human monoclonal antibody directed against TSHR, enhances in fibroblasts from patients and, if so, identify signaling mechanisms involved. fibroblast cultures (n=10) were treated for 10 days bovine (1 or 10.0 U/l)...
Spexin is a novel peptide that implicated in obesity and related energy homeostasis animals adult humans. Little known about its role children.The aim of the current study was to determine potential obese children explore relationships with various cardiometabolic risk factors.This cross-sectional composed 69 (51 18 normal weight; age 15.3 ± 0.26 y).Spexin measured using specific enzyme-linked immunosorbent assay. Leptin, total high-molecular-weight adiponectin, IL-6, high-sensitivity...
The signs and symptoms of Graves' ophthalmopathy (GO) result from increased volume the orbital contents, including adipose, connective, extraocular muscle tissues. We wanted to determine whether expanded adipose tissue might be in part attributable de novo adipogenesis. measured levels mRNA encoding leptin, adiponectin, peroxisome proliferator-activated receptor gamma (PPAR gamma), preadipocyte factor-1, TSH (TSHr) genes tissues GO patients (n = 22) normal individuals 18) cultures derived 6)...
There is ongoing concern that stimulant medications may adversely affect growth. In a sample of attention-deficit/hyperactivity disorder (ADHD) cases and controls from population-based birth cohort, we assessed growth the association between treatment
Surgically managed endocrinopathies are rare in children. Most surgeons have limited experience this field. Herein we report our operative with pediatric patients, performed over two decades by high-volume endocrine surgeons.The study was conducted at the Mayo Clinic (a tertiary referral center).Patients were <19 years old and underwent an operation (1993-2012).Demographics, surgical procedure, diagnoses, morbidity, mortality retrospectively reviewed.A total of 241 primary cases included 177...
Graves ophthalmopathy (GO) is an autoimmune disorder characterized by increased adipogenesis and hyaluronan (HA) production orbital fibroblasts. Circulating autoantibodies (thyroid-stimulating antibodies [TSAbs]) directed at the thyrotropin receptor (TSHR) on these cells stimulate or augment cellular processes. A recently developed drug-like small molecule inverse agonist of TSHR, NCGC00229600, termed 1, binds to TSHR blocks basal stimulated signal transduction.The purpose this article was...
Graves' ophthalmopathy (GO) is characterized by expanded volume of the orbital fat and extraocular muscle tissues elevated levels TSH receptor autoantibodies (TRAb). The expansion involves accumulation hyaluronic acid (HA) within orbit.The objective study was to determine whether a monoclonal stimulatory TRAb (M22) impacts HA synthesis in GO cells and, if so, this might be blocked an IGF-I (IGF-IR)-blocking antibody (1H7) or inhibitors various downstream signaling cascades.GO fibroblast...
In adults without thyroid disease, increasing levels of thyroid-stimulating hormone (TSH) within the range that considered normal have been shown to be associated with increases in total cholesterol, low-density lipoprotein non-high-density and triglycerides, decreases high-density cholesterol. Serum TSH has also found positively fasting postload insulin concentrations negatively sensitivity euthyroid adults. We hypothesized such relationships exist children adolescents.This was a...
<b><i>Background/Aims:</i></b> To determine the effect of vitamin D<sub>3</sub> supplementation on 25-hydroxyvitamin D [25(OH)D], lipid profile and markers insulin resistance in obese adolescents. <b><i>Methods:</i></b> In this double-blind, randomized, placebo-controlled trial, 58 adolescents (n = 58; 12-18 years age) received either (2,000 IU/day) or placebo for 12 weeks. Total 25(OH)D, fasting plasma glucose, were measured at...
<b><i>Background/Aims:</i></b> Vitamin D deficiency is highly prevalent in obese children, and children tend to respond poorly vitamin supplementation. The objective of the study was compare response D<sub>3</sub> supplementation (2,000 IU once daily for 12 weeks) between non-obese Caucasian adolescents. <b><i>Methods:</i></b> design was<b> </b>open label non-randomized. It carried out at a single center. Eighteen...
Summary Purpose Spexin, a novel peptide, has potential implications in obesity, satiety and energy homeostasis. The current study examined the relationship of spexin with various biomarkers cardiovascular disease endothelial function adolescents obesity. Methods Nineteen obesity (age, 15.8 ± 1.7 years) were studied. leptin measured. Endothelial was assessed by high‐resolution Doppler ultrasonography right brachial artery. Results Spexin concentration (median [interquartile range] 0.38 ng/mL...
Objective To assess the safety and efficacy of short‐term meal replacement therapy followed by topiramate for body mass index (BMI) reduction in adolescents with severe obesity. Methods Adolescents (ages 12–18 years) obesity (BMI ≥1.2 times 95th percentile or BMI ≥35 kg/m 2 ) were recruited this double‐blind, randomized, placebo‐controlled trial. Participants completed 4 weeks randomization (1:1) to either 24 75 mg/day placebo. Mean changes compared between groups. Results Thirty (mean age...
Graves’ ophthalmopathy (GO) is an autoimmune disorder involving the adipose and connective tissues of orbit. The study cytokines present in these may reveal nature cells immune responses involved GO pathogenesis. In current study, we performed relative quantification expression cytokine genes orbital tissue from patients with (n = 6) normal individuals 2). Real-time RT-PCR was using fluorescent probes primers for including IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IFN-γ, TNF-α. Results showed...
Intra-articular and intradermal steroids are often used for their antiinflammatory effect. There is limited experience with intra-articular intralesional administration of corticosteroids in the pediatric age group.We performed a retrospective chart review 3 patients who developed Cushing's syndrome after local triamcinolone acetonide (TCA).Two females 9 17 years old, received injections TCA. One patient multiple TCA into interphalangeal joints (cumulative dose: 120 mg), whereas other single...
Background: Patients with Graves' ophthalmopathy (GO) have circulating autoantibodies directed against the thyrotropin receptor (TSHR) and elevated levels of proinflammatory cytokine interleukin-6 (IL-6) in both serum orbital tissues. We hypothesized that these might increase IL-6 expression secretion preadipocyte fibroblasts adipocytes from patients GO, thus directly impact clinical activity disease. Methods:IL-6 mRNA were measured cultures GO preadipocytes (n = 3) treated during adipocyte...