A5033077951- Asthma and respiratory diseases
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
- Respiratory Support and Mechanisms
- Acute Lymphoblastic Leukemia research
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Mobile Health and mHealth Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Pharmaceutical studies and practices
- Birth, Development, and Health
- Respiratory and Cough-Related Research
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Antioxidant Activity and Oxidative Stress
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
Nemours Children's Health System
2016-2025
Thomas Jefferson University
2013-2025
Ahsanullah University of Science and Technology
2025
Dupont Hospital
2014-2023
University of Delaware
2013-2023
Christiana Care Health System
2023
Alfred I. duPont Hospital for Children
2013-2022
Arizona State University
2022
DuPont (United States)
2012-2021
National Institutes of Health
2021
To prospectively evaluate the effect of a comprehensive antimicrobial stewardship program on use, physician interventions, patient outcomes, and rates resistance.Active surveillance use with intervention real-time feedback to providers reinforcement prior authorization for selected antimicrobials were introduced at pediatric teaching hospital. Antimicrobial-use indications incorporated as mandatory field in computerized information system. An automated report prescribed, doses, demographics,...
Adult obesity is linked to asthma cases and estimated lead 250 000 new yearly. Similar incidence attributable risk (AR) estimates have not been developed for children. We sought describe the relationship between overweight incident in childhood quantify AR statistics United States on pediatric asthma.The PEDSnet clinical data research network was used conduct a retrospective cohort study (January 2009-December 2015) compare among and/or obese versus healthy weight 2- 17-year-old Asthma...
Spexin is a novel peptide that implicated in obesity and related energy homeostasis animals adult humans. Little known about its role children.The aim of the current study was to determine potential obese children explore relationships with various cardiometabolic risk factors.This cross-sectional composed 69 (51 18 normal weight; age 15.3 ± 0.26 y).Spexin measured using specific enzyme-linked immunosorbent assay. Leptin, total high-molecular-weight adiponectin, IL-6, high-sensitivity...
PLA-PVA films have desirable unique, unparalleled properties such as good oxygen and moisture barrier, excellent mechanical strength low toxicity. The biodegradability of PLA PVA offers a sustainable alternative to traditional plastic packaging. film stacking technology its potential benefits for XRD pattern exhibited sharp diffraction peaks at 20.0 ° 41.0 °, reflecting semi-crystalline nature, with the peak where main was found around 16.5 °. generally crystallizes in monoclinic unit cell...
The long-term effects of pure 17β-estradiol (E2) depending on route administration have not been well characterized. Our objective was to assess metabolic oral vs transdermal (TD) 17β-E2 replacement using estrogen concentration-based dosing in girls with Turner syndrome (TS). Forty TS, mean age 16.7 ± 1.7 years, were recruited. Subjects randomized orally or TD. Doses titrated E2 concentrations normally menstruating as therapeutic target. E2, estrone (E1), and E1 sulfate (E1S) measured by...
Growth of short children in puberty is limited by the effect estrogen on epiphyseal fusion. To compare: 1) efficacy and safety aromatase inhibitors (AIs) vs GH AI/GH increasing adult height potential pubertal boys with severe idiopathic stature (ISS); 2) differences body composition among groups. Randomized three-arm open-label comparator. Outpatient clinical research. Seventy-six [mean (SE) age, 14.1 (0.1) years] ISS [height SD score (SDS), −2.3 (0.0)]. Daily AIs (anastrozole or letrozole),...
Context. We evaluated the validity of Newest Vital Sign (NVS) as a brief screen for health literacy in children. Objectives. To ( a) test hypothesis that child performance on NVS correlates with reading comprehension and b) establish age-based cutoffs expected NVS. Design. Children aged 7 to 17 years were administered followed by Gray Silent Reading Test (GSRT). Results. The score correlated strongly GSRT (ρ = 0.71, P < .0001) increased age. 9 had median 1 (interquartile range 1-2);...
Abstract Context: Carotenoids have been implicated in the regulation of adipocyte metabolism. Objective: To compare effects mixed-carotenoid supplementation (MCS) versus placebo on adipokines and accrual abdominal adiposity children with obesity. Design Setting: Randomized (1:1), double-blind, placebo-controlled intervention trial to evaluate MCS over 6 months a subspecialty clinic. Participants: Twenty (6 male 14 female) simple obesity [body mass index (BMI) &gt; 90%], mean age (±...
The type, dose, and route of 17β-estradiol (E(2)) used to feminize girls with Turner syndrome (TS) is not well established.The objective the study was characterize pharmacokinetics pharmacodynamics oral vs. transdermal E(2).The conducted at a clinical research center.Ten TS, mean age 17.7 ± 0.4 (se) yr 20 normally menstruating controls (aged 16.8 yr) participated in study.TS subjects were randomized 2 wk each to: low-dose daily (0.5 mg) biweekly E(2) (0.0375 washout between or high-dose (2.0...
Objective: To determine if metformin improves markers of inflammation, thrombosis, and intrahepatic fat contents in children with uncomplicated obesity.
Summary Purpose Spexin, a novel peptide, has potential implications in obesity, satiety and energy homeostasis. The current study examined the relationship of spexin with various biomarkers cardiovascular disease endothelial function adolescents obesity. Methods Nineteen obesity (age, 15.8 ± 1.7 years) were studied. leptin measured. Endothelial was assessed by high‐resolution Doppler ultrasonography right brachial artery. Results Spexin concentration (median [interquartile range] 0.38 ng/mL...
mRNA localization provides polarized cells with a locally renewable source of proteins. In neurons, translation can occur at millimeters to centimeters from the cell body, giving dendritic and axonal processes means autonomously respond their environment. Despite that hundreds mRNAs have been detected in neuronal processes, there are no reliable predict elements. Here, we asked what RNA elements needed for transcripts encoding endoplasmic reticulum chaperone proteins neurons. The...
ObjectiveTo determine the effects of placebo vs an encapsulated supplement fruit and vegetable juice concentrate (FVJC) on serum β-carotene levels, insulin resistance, adiposity, subclinical inflammation in boys.Study designThirty age-matched prepubertal boys (9 lean 21 overweight (OW); age range, 6-10 years) were studied. All participants received nutrition counseling randomized to receive FVJC or capsules for 6 months. Total cholesterol, triglycerides, lipid corrected β-carotene, retinol,...
Objective. The relationship between weight status and asthma characteristics in children remains inadequately defined. Very little has been published on the risk of exacerbation, physician perception severity, level controller treatment prescribed to underweight obese with a real-world setting. Methods. We assessed diagnostic pulmonary function, exacerbation prevalence, 10,559 new patients seen at one four pediatric subspecialty clinics among three BMI groups. Participants were analyzed by...
Pediatric thyroid carcinoma is relatively uncommon. But variability in incidence rate by race, sex, age at onset/diagnosis, and geographic local had been observed adult the USA. We aimed to examine patterns, rates, temporal trends of among pediatric patients (0–19 years) between 1973 2007. The Surveillance, Epidemiology, End Results (SEER) data National Cancer Institute were utilized. Data available on diagnosis, race/ethnicity, locale (9 SEER registries) used for rates computation....
Keratan sulfate (KS) is a storage material in mucopolysaccharidosis IV (MPS IV). However, no detailed analysis has been reported on subclasses of KS: mono-sulfated KS and di-sulfated KS. We established novel method to distinguish quantify mono- using liquid chromatography–tandem mass spectrometry measured both levels various specimens. Di-sulfated was dominant shark cartilage rat serum, while bovine cornea human serum. Levels varied with age the blood urine from control subjects patients MPS...
Age at diagnosis is a key prognostic factor in pediatric acute lymphoblastic leukemia (ALL) survivorship. However, literature providing adequate assessment of the survival variability by age scarce. The aim this study to assess impact ALL survival. We estimated incidence rate mortality, 5-year rate, Kaplan-Meier function, and hazard ratio using Surveillance Epidemiology End Results (SEER) data during 1973-2009. There was significant diagnosis. Survival peaked among children diagnosed 1-4...