A5078998706- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Pancreatic function and diabetes
- Diet and metabolism studies
- Estrogen and related hormone effects
- Pituitary Gland Disorders and Treatments
- Innovations in Medical Education
- Health Sciences Research and Education
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Diabetes and associated disorders
- Discrimination and Equality Law
- Glioma Diagnosis and Treatment
- Clinical Reasoning and Diagnostic Skills
- Sex and Gender in Healthcare
- Adrenal and Paraganglionic Tumors
- Metabolism, Diabetes, and Cancer
Nemours Children's Health System
2016-2024
Mayo Clinic in Florida
2019
Jacksonville College
2019
WinnMed
2019
University of Virginia
2019
University of Chile
2019
University of Pennsylvania
2019
Nemours Children's Clinic
2013
University of Florida
2013
The long-term effects of pure 17β-estradiol (E2) depending on route administration have not been well characterized. Our objective was to assess metabolic oral vs transdermal (TD) 17β-E2 replacement using estrogen concentration-based dosing in girls with Turner syndrome (TS). Forty TS, mean age 16.7 ± 1.7 years, were recruited. Subjects randomized orally or TD. Doses titrated E2 concentrations normally menstruating as therapeutic target. E2, estrone (E1), and E1 sulfate (E1S) measured by...
The established link between oestrogen and breast cancer occurs via both receptor (ER)-mediated non ER-mediated mechanisms. term genotoxic estrogens describes mutagenic metabolites, including catechols quinones, which have been linked to carcinogenesis in post-menopausal women. We aimed assess whether the route of administration 17β oestradiol (E2 ) affects accumulation metabolites a model ovarian failure young girls with Turner syndrome.Stored plasma samples obtained at 0 12 months were...
Abstract Context The assessment and treatment of children with growth retardation is increasingly complex, due to availability targeted genetic sequencing, an ever-expanding number conditions impeding are being identified. Among endocrine-related etiologies short stature amenable hormonal treatment, defects in the hormone (GH)–insulin-like factor I axis remain pre-eminent, a multiplicity disorders causing decreased secretion or insensitivity GH action. Sex steroids puberty increase...
Tumors involving the sella are commonly craniopharyngiomas, optic pathway gliomas, or pituitary adenomas. Functioning adenomas expected, with prolactinomas topping differential. The authors present case of a silent corticotroph adenoma, which has not been described in pediatric population, and they detail use proton therapy, is also novel.
Among patients with Turner Syndrome (TS), premature ovarian failure is a main feature. Recently published consensus guidelines recommend that transdermal (TD) estradiol the preferred route for estrogen replacement. Studies related to ultrasound (US) measurements during replacement in TS using (17β E2) and correlating uterine growth metabolites are limited.To compare morphology hormonal changes depending on of administration 17β E2 (oral vs. TD) small population girls TS.11 hypogonadal (mean...
Abstract Objective: The established link between estrogen and breast cancer occurs via both receptor (ER)-mediated non ER-mediated mechanisms. term genotoxic estrogens describes mutagenic metabolites, including catechols quinones, which have been linked to carcinogenesis in post-menopausal women. Recent data showed that childhood obesity is associated with significantly higher levels of the blood compared lean children, raising possibility a potential pathogenic roles these metabolites...