A5066888960- Ethics in Clinical Research
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Vitamin D Research Studies
- Autoimmune and Inflammatory Disorders Research
- Prostate Cancer Treatment and Research
- Pharmaceutical Economics and Policy
- Telemedicine and Telehealth Implementation
- Muscle metabolism and nutrition
- Biomedical Ethics and Regulation
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Vitamin C and Antioxidants Research
- Adolescent and Pediatric Healthcare
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- Healthcare Systems and Public Health
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Artificial Intelligence in Healthcare
- Biosimilars and Bioanalytical Methods
- Electronic Health Records Systems
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- Digestive system and related health
Memorial Sloan Kettering Cancer Center
2018-2025
InterSystems (United States)
2025
Duke University
2024
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2024
Johnson & Johnson (Israel)
2024
Astellas Pharma (China)
2024
Merck (Singapore)
2024
Innovative Clinical Research
2024
Izaak Walton Killam Health Centre
2022
Background Sorafenib monotherapy in patients with metastatic melanoma was explored this multi-institutional phase II study. In correlative studies the impact of sorafenib on cyclin D1 and Ki67 assessed. Methodology/Principal Findings Thirty-six treatment-naïve advanced received 400 mg p.o. twice daily continuously. Tumor BRAFV600E mutational status determined by routine DNA sequencing mutation-specific PCR (MSPCR). Immunohistochemistry (IHC) staining for performed available pre- post...
Abstract Background Treatment options for patients with recurrent superficial bladder cancer are limited, necessitating aggressive exploration of new treatment strategies that effectively prevent recurrence and progression to invasive disease. We assessed the effects belinostat (previously PXD101), a novel histone deacetylase inhibitor, on panel human cell lines representing disease, transgenic mouse model cancer. Methods Growth inhibition cycle distribution effect 5637, T24, J82, RT4...
Real-time monitoring of hydration biomarkers in tandem with biophysical markers can offer valuable physiological insights about heat stress and related thermoregulatory response. These metrics have been challenging to achieve wearable sensors. Here we present a closed-loop electrochemical/biophysical sensing device algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, loss electrode arrays embedded microfluidic channel. The contains two temperature...
PURPOSE Clinical trials are integral for patients with cancer but remain inaccessible to many because of barriers including geographic and transportation challenges. This study aimed evaluate patients' preferences telemedicine versus in-person visits clinical trial discussions informed consent (IC). METHODS An electronic survey was administered first-time users at Memorial Sloan Kettering Cancer Center from 2021 2023. The assessed the IC process their comfort discussing virtually. primary...
Abstract Increased androgen receptor (AR) expression and activity are pivotal for androgen-independent (AI) prostate cancer (PC) progression resistance to androgen-deprivation therapy. We show that a novel transcriptional repressor complex binds specific sequence (repressor element) in the AR gene 5′-untranslated region contains Purα hnRNP-K. expression, its nuclear localization, promoter association, as determined by chromatin immunoprecipitation analysis, were found be significantly...
Abstract Background The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First-line options sJIA (FROST) was a prospective observational study assess CTP outcomes using the CARRA Registry. Methods Patients with new-onset were enrolled if they received initial according biologic CTPs (IL-1 or IL-6 inhibitor) non-biologic (glucocorticoid (GC) monotherapy...
eSource software that transfers patient electronic health record data into a clinical trial case report form holds promise for increasing quality while reducing collection, monitoring and source document verification costs. Integrating multicenter start-up procedures could facilitate the use of technologies in trials.
To report baseline characteristics, patient reported outcomes and treatment of children with Juvenile Dermatomyositis (JDM) in the Childhood Arthritis Rheumatology Research Alliance (CARRA) Registry.Children newly diagnosed JDM were enrolled CARRA Registry from 41 pediatric rheumatology centers. Baseline demographics, disease assessments, outcome treatments recorded.In first year, 119 participants enrolled. Most female (63.4%), white (72.3%) a median diagnosis age 8.0 years (IQR 4.0-11.5),...
Abstract Background Different Insulin-like Growth Factor Binding Proteins (IGFBPs) have been investigated as potential biomarkers in several types of tumors. In this study, we examined both IGFBP-3 and -4 levels tissues sera melanoma patients representing different stages progression. Methods The study cohort consisted 132 (primary, n = 72; metastatic, 60; 64 Male, 68 Female; Median Age 56) prospectively enrolled the New York University School Medicine Interdisciplinary Melanoma Cooperative...
INTRODUCTION: Manual transcription of site clinical trial data into sponsor Electronic Data Capture (EDC) systems is labor intensive and error prone. Herein, we describe Direct Extraction (DDE) best practices identified by the Society for Clinical Management eSource Consortium that will enable other groups to implement DDE their own research efforts. OBJECTIVES: The primary objective this study was show efficiency gains return on investment implementing compared traditional manual entry...
9072 Background: This is a completed outcome analysis of phase II trial S in MM which aimed to determine if treatment (tx) with altered tumor proliferation,and induced differential anti-tumor responses (resp) wt or mutB-Raf MM. Mutation detection was performed using newly developed fluorescent based mutant-specific PCR assay (MS-PCR). Methods: Biopsy (bx)-accessible, untreated measurable disease (RECIST). Stratification:Tumor BRAF status at codon V600 by routine sequencing and MS-PCR. Tx:...
e18577 Background: The eIC platform was developed to reduce administrative time and effort associated with paper-based consenting, improve the IC audit trail, augment educational alternatives for research subjects. includes 3 distinct tools: 1) module where consent form is reviewed/signed; 2) an management tool that sets user level access permissions, 3) a processing utility ensures most recent IRB-approved discussed, displays metrics completed consents, transmits signed forms electronic...
Consent processes are critical for clinical care and research may benefit from incorporating digital strategies. We compared an electronic informed consent (eIC) option to paper across four outcomes: (1) technology burden, (2) protocol comprehension, (3) participant agency (ability self-advocate), (4) completion of required document fields.
eSource software that copies patient electronic health record data into a clinical trial case report form holds promise for increasing quality while reducing collection, monitoring and source document verification costs. Integrating multicenter start-up procedures could facilitate the use of technologies in trials.
e13651 Background: Manual abstraction of data from a site’s clinical systems to biopharmaceutical firm’s electronic capture (EDC) system is inefficient and error prone. In partnership with managers (DMs), we used human-centered design thinking methodology create web application, CTDataHub, reduce the effort associated this process. CTDataHub extracts consolidates adverse events (AE) concomitant medications (ConMed) displays it in user-friendly view for easy entry into EDCs. Methods: was...