A5028547214- Economic and Financial Impacts of Cancer
- COVID-19 and healthcare impacts
- Telemedicine and Telehealth Implementation
- Cancer survivorship and care
- COVID-19 Clinical Research Studies
- Medication Adherence and Compliance
- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Migraine and Headache Studies
- Clinical practice guidelines implementation
- Infection Control and Ventilation
- Cardiovascular Syncope and Autonomic Disorders
- Poisoning and overdose treatments
- Mobile Health and mHealth Applications
- Biosimilars and Bioanalytical Methods
- Blood groups and transfusion
- Acute Lymphoblastic Leukemia research
- Adenosine and Purinergic Signaling
- Polyomavirus and related diseases
- Digital Mental Health Interventions
Memorial Sloan Kettering Cancer Center
2023-2025
University of Pennsylvania
2018-2025
Varian Medical Systems (Switzerland)
2024
AstraZeneca (Finland)
2024
Astellas Pharma (China)
2024
AstraZeneca (Brazil)
2024
Pfizer (United Kingdom)
2024
Bayer (Germany)
2024
Sidney Kimmel Cancer Center
2022
Abramson Cancer Center
2021-2022
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients who were hospitalized for COVID-19, hematologic had higher relative to solid cancer. two additional cohorts, flow cytometric serologic analyses demonstrated without similar phenotype during acute whereas impairment B cells severe respiratory syndrome 2 (SARS-CoV-2)-specific antibody responses. Despite impaired...
The STK11 gene encodes a serine/threonine protein kinase that regulates cell polarity and functions as tumor suppressor. Patients with non-small-cell lung cancer (NSCLC) mutations often have other co-mutations. We evaluated the impact of KRAS TP53 co-mutations on outcomes after first-line systemic therapy for patients metastatic or recurrent NSCLC harbors mutations.We conducted retrospective review treated at University Pennsylvania. were identified through next-generation sequencing (NGS)...
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer hospitalized for COVID-19 at University Pennsylvania Health System, we found that with hematologic cancers had significantly higher relative to solid after accounting confounders including ECOG performance status active status. We performed flow cytometric serologic analyses 106 113 non-cancer controls two additional...
The median overall survival (OS) for metastatic pancreatic ductal adenocarcinoma (mPDAC) is < 1 year. Factors that contribute to quality of life during treatment are critical quantify. One factor-time spent obtaining clinical services-is understudied. We quantified total outpatient time among patients with mPDAC receiving palliative systemic chemotherapy.We conducted a retrospective analysis using four patient-level measures calculated from the medical record 5-fluorouracil infusion,...
Abstract The COVID-19 pandemic placed a spotlight on the potential to dramatically increase use of telehealth across cancer care continuum, but whether and how can be implemented in practice ways that reduce, rather than exacerbate, inequities are largely unknown. To help fill this critical gap research practice, we developed Framework for Integrating Telehealth Equitably (FITE), process evaluation model designed guide equitable integration into practice. In manuscript, present FITE showcase...
Abstract Cancer patients are a vulnerable population postulated to be at higher risk for severe coronavirus disease 2019 (COVID-19) infection. Increased COVID-19 morbidity and mortality in cancer may attributable age, comorbidities, smoking, health care exposure, treatments, partially the itself. Most studies date have focused on hospitalized with COVID-19, thereby limiting generalizability interpretability of association between severity. We compared outcomes SARS-CoV-2 infection 323...
PURPOSE Clinical trials are integral for patients with cancer but remain inaccessible to many because of barriers including geographic and transportation challenges. This study aimed evaluate patients' preferences telemedicine versus in-person visits clinical trial discussions informed consent (IC). METHODS An electronic survey was administered first-time users at Memorial Sloan Kettering Cancer Center from 2021 2023. The assessed the IC process their comfort discussing virtually. primary...
Abstract Objective To examine trends in diagnosis of headache and migraine a large pediatric neurology cohort, test whether an electronic health record (EHR)‐integrated questionnaire can increase specificity likelihood prescribing treatment. Background Under‐diagnosis contributes to the burden disease. As we founded our Pediatric Headache Program 2013, recognized that proportion patients with who were given was much lower than expected. Methods We developed patient questionnaire, initially...
Immunotherapy Adverse Effects ImmunotherapyImmunotherapies treat many types of cancer.These drugs are not chemotherapy; instead, they use the body's immune system to target cancer.Most people do have serious adverse effects from these medicines.When happen, it is because mistakenly targets a person's healthy cells.This called an immune-related event, or irAE.
Abstract Background Despite the widespread implementation of telemedicine, there are limited data regarding its impact on key components care for patients with incurable or high‐risk cancer. For these patients, high‐quality requires detailed conversations treatment priorities (advance planning) and clinical to minimize unnecessary acute (unplanned hospitalizations). Whether telemedicine affects outcomes relative in‐person clinic visits was examined among cancer at high risk 6‐month...
Modern cancer care is costly and logistically burdensome for patients their families despite an expansion of technology medical advances that create the opportunity novel approaches to care. Therefore, there a growing appreciation need leverage these innovations make more patient centered convenient. The Memorial Sloan Kettering Making Telehealth Delivery Cancer Care at Home Efficient Safe Research Center National Institute-designated funded Excellence poised generate evidence necessary...
Abstract Cancer patients are a vulnerable population postulated to be at higher risk for severe COVID-19 infection. Increased morbidity and mortality in cancer may attributable age, comorbidities, smoking, healthcare exposure, treatments, partially the itself. Most studies date have focused on hospitalized with COVID-19, thereby limiting generalizability interpretability of association between severity. We compared outcomes SARS-CoV-2 infection 323 enrolled prior pandemic large academic...
This cross-sectional study examines whether patients with cancer without symptoms of immune checkpoint inhibitor toxic effects can be accurately identified using a text message–based triage instrument and safely proceed to treatment.
1537 Background: Patients spend substantial time receiving cancer care, and innovative strategies to decrease toxicity are needed. We have shown that a text-based triage can identify patients tolerating checkpoint inhibitors (ICI) without who could safely fast-track directly ICI infusion. However, oncologists’ readiness implement this strategy is unknown. Methods: This sequential mixed-methods study included oncologists treating solid-tumor with ICIs at Penn Medicine. In phase 1,...
1637 Background: The Making Telehealth Delivery of Cancer Care at Home Effective and Safe for Immunotherapy (MATCHES-IO) intervention seeks to improve the efficiency patient experience those treated with single agent pembrolizumab. Because pembrolizumab is administered as an outpatient infusion every 3-weeks, patients require up 18 clinic visits per year receive treatment, which arduous. During COVID-19 pandemic, FDA granted accelerated approval extended interval dosing 6 weeks, but despite...
1632 Background: Telemedicine, once sparingly utilized, surged during the COVID-19 pandemic to enhance care accessibility and safety concerns. Despite initial satisfaction, its usage remains highly variable across institutions. We sought explore patient satisfaction at a comprehensive cancer center, associations with demographic characteristics, change over time. Methods: A survey was sent all first-time telemedicine users Memorial Sloan Kettering Cancer Center from September 2021 October...