A5075256713- Ethics in Clinical Research
- Multiple Myeloma Research and Treatments
- Biomedical Ethics and Regulation
- Electronic Health Records Systems
- Artificial Intelligence in Healthcare
- Artificial Intelligence in Healthcare and Education
- Data Quality and Management
- Biomedical Text Mining and Ontologies
- Scientific Computing and Data Management
- Social Media in Health Education
- Service-Oriented Architecture and Web Services
- Machine Learning in Healthcare
- Histone Deacetylase Inhibitors Research
- Medication Adherence and Compliance
- Healthcare Systems and Public Health
- Patient-Provider Communication in Healthcare
- Mobile Health and mHealth Applications
- Telemedicine and Telehealth Implementation
- Multiple Sclerosis Research Studies
- Bone health and treatments
Memorial Sloan Kettering Cancer Center
2018-2024
Due to the nature of their disease, patients with multiple myeloma (MM) often have bone disease-related pain that limits physical activity and diminishes health-related quality life (HRQOL). Digital health technology wearables electronic patient reported outcome (ePRO) tools can provide insights into MM HRQoL.
Consent processes are critical for clinical care and research may benefit from incorporating digital strategies. We compared an electronic informed consent (eIC) option to paper across four outcomes: (1) technology burden, (2) protocol comprehension, (3) participant agency (ability self-advocate), (4) completion of required document fields.
e18577 Background: The eIC platform was developed to reduce administrative time and effort associated with paper-based consenting, improve the IC audit trail, augment educational alternatives for research subjects. includes 3 distinct tools: 1) module where consent form is reviewed/signed; 2) an management tool that sets user level access permissions, 3) a processing utility ensures most recent IRB-approved discussed, displays metrics completed consents, transmits signed forms electronic...
e13651 Background: Manual abstraction of data from a site’s clinical systems to biopharmaceutical firm’s electronic capture (EDC) system is inefficient and error prone. In partnership with managers (DMs), we used human-centered design thinking methodology create web application, CTDataHub, reduce the effort associated this process. CTDataHub extracts consolidates adverse events (AE) concomitant medications (ConMed) displays it in user-friendly view for easy entry into EDCs. Methods: was...
Clinical Research Coordinators (CRC) are the backbone of clinical trials, conducting extensive data work to support research team. Existing systems, optimized for document management rather than research, offer limited capabilities CRCs' workflow, making retrieval laborious and error-prone. CTDataHub is an information system designed through participatory design with CRCs at a large academic medical center address these challenges empower them as workers. This study discusses impact that had...
e13624 Background: Manual abstraction of data from a site’s EHR to pharmaceutical sponsor’s EDC system is labor intensive and inefficient. To reduce the time effort this process for managers (DM), web-based application, Clinical Trials Data Hub (CTDH), was developed using Design Thinking methods. It extracts consolidates AE ConMed displays it in user friendly, automated, consolidated view easy entry into forms. Methods: Following DT methodology develop CTDH, we interviewed 12 DMs identify...
2066 Background: eConsent was developed to digitize the research participant consenting experience with an educational engagement model. The platform tiers consent document content in easy-to-navigate format, using videos, images, and access supplementary information. We hypothesize that enhancing improves comprehension. Methods: Here we present two projects: 1) qualitative assessment of patient process a standardized 5-question survey sent all patients who used it during 9 months 2019, 2)...
1514 Background: Based on our previous research with patient satisfaction for electronic consenting (95% of 940 respondents would recommend it another patient), we hypothesized that telemedicine (telemed) be received as well or better than in-person clinical (CR) consent encounters complex early-phase trial (Phase I-II) and genetic discussions by patients. Oncologist experiences to date have shown telemed works uncomplicated scenarios, but its performance alongside increased care complexity...
8040 Background: Passive monitoring using wearables can objectively measure sleep over extended time periods. MM patients (PTs) are susceptible to fluctuating patterns due pain and dexamethasone (dex) treatment. In this prospective study, we remotely monitored on 40 newly diagnosed (NDMM) PTs while administering electronic PT reported outcome (ePRO) surveys. The study aim was establish bioprofiles during therapy correlate with ePROs. Methods: Eligible for the had untreated NDMM assigned...
516 Background: Telemedicine (TM) disparities in the US during pandemic are well-reported; however, its use by diverse participants providing electronic informed consent (eIC) for clinical trials oncology remains unexplored. Our previous research found eIC comparable to in-person paper-based visits across participants: stress, technology burden, comprehension, and agency complex genetic Phase I-II trial discussions. Based on this work, we hypothesized that our implementation of via TM would...
Background: Wearable devices can objectively monitor and aggregate 'activity' data continuously for prolonged periods. Due to the nature of their disease, multiple myeloma (MM) patients often have bone disease-related pain that limits activity diminishes health-related quality life (HRQOL). Digital health technology with wearables electronic patient reported outcome (ePRO) tools provide insights into MM HRQoL. Methods: Newly diagnosed were remotely monitored physical at baseline up 6 cycles...