A5045548326- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- Gestational Diabetes Research and Management
- Prenatal Substance Exposure Effects
- Pregnancy and preeclampsia studies
- Acute Lymphoblastic Leukemia research
- Birth, Development, and Health
- Rheumatoid Arthritis Research and Therapies
- Kawasaki Disease and Coronary Complications
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Esophagitis
- Homelessness and Social Issues
- Immunodeficiency and Autoimmune Disorders
- Family and Disability Support Research
- Assisted Reproductive Technology and Twin Pregnancy
- Acupuncture Treatment Research Studies
- COVID-19 and healthcare impacts
- Ethics in Clinical Research
- Lymphadenopathy Diagnosis and Analysis
- Ear and Head Tumors
- Menstrual Health and Disorders
- Subtitles and Audiovisual Media
- Delphi Technique in Research
Hospital for Sick Children
2010-2025
Institute for Clinical Evaluative Sciences
2021-2025
SickKids Foundation
2006-2025
Duke University
2024
University of California San Francisco Medical Center
2022
University of Alabama at Birmingham
2022
University College London
2020-2021
Great Ormond Street Hospital
2020-2021
Hackensack University Medical Center
2021
University of California, San Francisco
2021
Data from the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) registry suggests that reliable collection of patient-reported outcomes (PROs) varies across sites. The objective this study was to better understand practices collecting PROs at PR-COIN A REDCap survey sent lead representative for each site. Registry data were analyzed completion rates PROs. Interviews physician leaders high performing sites conducted by videoconference, audiotranscribed themes summarized....
Objective Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has defined using NanoString technology and appears to correlate with cross-sectional samples JDM patients. This study aimed determine if there is evidence a correlation between IRG-score, patients JDM, both early course longitudinally. Methods All attending clinic SickKids were approached enrol the...
A retrospective study of 18 patients with malignant tumors the external auditory canal and temporal bone was undertaken to gain an Asian perspective this rare disease. Of these patients, 15 (83%) had squamous cell carcinoma (SCC) 61% stage T3 at presentation. The mean age 56 years (range 38-82 years). Seven (39%) radiation-associated (RATs), all undergone radiotherapy for treatment nasopharyngeal carcinoma. 1-year cumulative recurrence RAT group 100%, but there no in non-RAT (P = 0.001). In...
Introduction Approximately 25% of all babies in North America are delivered via Caesarean section (C-section). Though a common surgical procedure, C-section recovery can be painful. Opioids, specifically codeine, commonly used to ease pain; however, its active metabolite, morphine, passes into breast milk, and may produce unwanted side effects neonates; therefore, alternatives opioids being sought. Reiki is an ancient Japanese form healing where practitioners transfer energy through light...
Abstract Background Patient reported outcome measures (PROMs) provide valuable insight on patients’ well-being and facilitates communication between healthcare providers their patients. The increased integration of the technology within setting presents opportunity to collect PROMs electronically, rather than paper. Childhood Health Assessment Questionnaire (CHAQ) Quality My Life (QoML) are common collected from pediatric rheumatology objectives this study (a) determine equivalence paper...
Objective Grapefruit juice increases the oral bioavailability of several drugs metabolized by cytochrome P450 3A4. This study investigated influence grapefruit on pharmacokinetics cisapride, a substrate CYP3A4. Methods Fourteen healthy volunteers received in random order 10 mg cisapride (Prepulsid) with 250 mL water or after an overnight fast. Blood samples were taken for 25 hours and urine was collected 36 dosing. Plasma concentrations urinary norcisapride measured HPLC. The pharmacokinetic...
Children and adolescents with juvenile idiopathic arthritis (JIA) are less physically active than their healthy peers at high risk of missing out on the general health benefits physical activity. Wearable activity trackers a promising option for intervening in this population potential advantages over traditional exercise prescriptions. The objectives study were to: (1) determine feasibility wearable tracker intervention JIA; (2) estimate variability response to levels JIA. Participants aged...
Healthcare providers were rapidly forced to modify the way they practiced medicine during coronavirus disease 2019 (COVID-19) pandemic. Many transitioned from seeing their patients in person virtually using telemedicine platforms with limited training and experience this medium. In pediatric rheumatology, was further complicated as musculoskeletal exams typically require hands-on assessment of patients. The objective study examine adoption into rheumatology practices, assess its benefits...
Abstract Background The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First-line options sJIA (FROST) was a prospective observational study assess CTP outcomes using the CARRA Registry. Methods Patients with new-onset were enrolled if they received initial according biologic CTPs (IL-1 or IL-6 inhibitor) non-biologic (glucocorticoid (GC) monotherapy...
Abstract Aggressive fibromatosis (also called desmoid tumor) is a benign, locally invasive, soft tissue tumor composed of cells with mesenchymal characteristics. These tumors are characterized by increased levels β-catenin–mediated T-cell factor (TCF)–dependent transcriptional activation. We found that type 1 IFN signaling activated in human and murine aggressive the expression associated response genes regulated β-catenin. When mice deficient for receptor (Ifnar1−/−) were crossed...
Since 2010, the rheumatology community has developed guidelines and tools to improve healthcare transition. In this study, we aimed compare current transition practices beliefs among Childhood Arthritis Rheumatology Research Alliance (CARRA) providers with from a provider survey published in 2010.In 2018, CARRA members completed 25-item online about Got Transition's Current Assessment of Health Care Transition Activities was used measure clinical processes on scale 1 (basic) 4...
The transition from pediatric to adult care is the focus of growing research. It important identify how direct future research efforts for maximum effect. Our goals were perform a scoping review literature, highlight gaps in research, and offer stakeholder guidance on importance feasibility questions designed fill identified gaps. literature rheumatic diseases other common pediatric-onset chronic was grouped summarized. Based findings, survey developed disseminated rheumatologists young...
To develop, validate, and test the performance of patient-reported outcomes (PROs) in a short patient questionnaire (< 5 minutes length) order to assess multidimensional aspects orofacial symptoms related juvenile idiopathic arthritis (JIA) among patients aged ≥ 10 years.The study was conducted by an interdisciplinary task force from Temporomandibular Joint Juvenile Arthritis Working Group. The project consisted multiphased approach including following: (1) conceptual phase with online...
Juvenile Dermatomyositis (JDM) is a rare, chronic, and life-threatening childhood autoimmune disease. Currently, there are recommended, reliable validated measurement tools for assessment of skin disease activity in JDM including the Disease Activity Score (skinDAS), Cutaneous Assessment Tool (CAT), Area Severity Index (CDASI). The Physician's global visual analog scale (Skin VAS) also widely used JDM. For purpose comparative international studies, we wanted to compare these VAS (as...