A5056672566- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Metabolism and Genetic Disorders
- Urinary Bladder and Prostate Research
- Pharmaceutical studies and practices
- Solid State Laser Technologies
- Advanced Fiber Laser Technologies
- Respiratory and Cough-Related Research
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects and Assays
- Cancer Treatment and Pharmacology
- Anesthesia and Sedative Agents
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
- Prostate Cancer Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Epilepsy research and treatment
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Lymphocytic Leukemia Research
- Urological Disorders and Treatments
GlaxoSmithKline (United Kingdom)
2005-2024
The University of Sydney
1999-2023
GlaxoSmithKline (Australia)
2011-2023
GlaxoSmithKline (India)
2023
Asklepios Klinik Barmbek
2012-2020
Creative Commons
2016
St Vincent's Hospital Sydney
2016
Forschungsinstitut für Mineralische und Metallische Werkstoffe Edelsteine/Edemetalle
2007-2013
Monash University
2013
Concord Repatriation General Hospital
2013
The aim of this study was to compare the effects total sleep deprivation (TSD), rapid eye movement (REM) and slow wave (SWS) interruption recovery on mechanical thermal pain sensitivity in healthy adults. Nine male volunteers (age 26–43 years) were randomly assigned double blind crossover undergo either REM or SWS interruption. Periods 6 consecutive laboratory nights separated by at least 2 weeks designed as follows: N1 Adaptation night; N2 Baseline N3 Total (40 h); N4 N5 interruption; N6...
<b>Objective</b> To determine whether fluoroscopic guidance improves outcomes of injections for greater trochanteric pain syndrome. <b>Design</b> Multicentre double blind randomised controlled study. <b>Setting</b> Three academic and military treatment facilities in the United States Germany. <b>Participants</b> 65 patients with a clinical diagnosis <b>Interventions</b> Injections corticosteroid local anaesthetic into bursa, using fluoroscopy (n=32) or landmarks (that is, "blind" injections;...
Objective. Hypersensitivity to trimethoprim-sulphamethoxazole (TMP-SMX) is more common in patients with HIV infection. In non-infected patients, TMP-SMX hypersensitivity those a slow acetylator phenotype. This study was conducted determine whether the acetylation phenotype associated an increased risk of Methods. Acetylation determined 28 HIV-infected subjects, whom 16 had prior and 12 received long-term therapy without hypersensitivity, as well 29 healthy controls. by measuring ratio two...
The aim of this study was to investigate the activity drug-metabolizing enzyme cytochrome P450 (CYP) 2B6 before and after in vivo induction by rifampin (INN, rifampicin) white subjects Chinese use probe drug bupropion amfebutamone).Healthy male (n = 9) (age range, 19-34 years) known CYP2B6 genotype received orally administered (Zyban SR, 150 mg) alone during daily treatment with (600 mg). Blood samples were taken for up 72 hours each dose, plasma concentrations its active metabolites,...
Abstract Objectives To investigate the utility of metrics CYP1A2 activity using caffeine as a probe, and saliva plasma sampling with or without 24-h abstinence. Methods This was cross-over pharmacokinetic study in 30 healthy male subjects who received single oral 100 mg dose after abstinence maintaining their regular intake (no abstinence). Serial blood samples were collected simultaneously over 24 h. Caffeine paraxanthine concentrations measured validated HPLC assay. Key findings There...
The pharmacokinetics and urinary excretion of flecainide (50 mg administered orally) were investigated in five extensive metabolizers (EMs) poor (PMs) the sparteine/debrisoquin type polymorphism under conditions controlled pH. Flecainide disposition was altered PMs. AUC higher (1462 ± 407 versus 860 256 hr ng/ml), elimination half-life prolonged (11.8 6.8 hours), amount excreted urine (26.7 7.2 15.4 1.3 mg) PMs compared with EMs (p < 0.05). Oral clearance reduced 0.019) (600 139 1041 307...
The drug-metabolizing enzyme CYP1A2 contributes to the metabolism of a number commonly used medicines and displays wide interindividual variability. aim this study was investigate activity in population South Asian ancestry compare it with European ancestry. determined using 4 h paraxanthine/caffeine saliva concentration ratio following 100-mg oral dose caffeine healthy individuals (n = 166) Participants were surveyed for extrinsic ethnic factors genotyped polymorphisms related genes....
Objective Proteins involving absorption, distribution, metabolism, and excretion (ADME) play a critical role in drug pharmacokinetics. The type frequency of genetic variation the ADME genes differ among populations. aim this study was to systematically investigate common rare coding diverse ethnic populations by exome sequencing. Materials methods Data derived from commercial capture arrays next-generation sequencing were used characterize 298 251 Northeast Asians 1181 individuals 1000...
1. The disposition of the enantiomers antiarrhythmic drug flecainide has been studied in five extensive (EM) and poor (PM) metabolisers sparteine/debrisoquine after administration 50 mg racemic acetate under conditions high urinary flow rate acidic pH. 2. In EM subjects there were no significant differences oral clearance, half-life or excretion (+)-S- (-)-R-flecainide. 3. PM pharmacokinetics S- R-flecainide observed. clearance (467 +/- 109 ml min-1) was less (P than 0.03) that S-enantiomer...
To identify the human cytochrome P450 (CYP) enzymes responsible for formation of 6beta-hydroxy (6beta-OHGz), 7beta-hydroxy (7beta-OHGz) and hydroxymethyl (MeOH-Gz) metabolites gliclizide (Gz).6beta-OHGz, 7beta-OHGz MeOH-Gz by liver microsomes a panel recombinant P450s was measured using high-performance liquid chromatography procedure, kinetics metabolite determined each pathway. Effects prototypic CYP enzyme selective inhibitors were characterized microsomal metabolic pathways.Microsomes...
Caffeine has been extensively used as a probe to measure CYP1A2 activity in humans with caffeine clearance or the paraxanthine (major metabolite of caffeine) concentration ratio being regarded preferred metric. A simple reverse-phased C(18) HPLC assay using ethyl acetate liquid-liquid extraction was developed quantitate and concentrations saliva plasma. The mobile phase consisted acetonitrile-acetic acid-H(2)O (100:1:899) analytes were quantitated UV detection at 280 nm. recovery for...
Introduction: Investigating variation in genes involved the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene is relatively well characterized European Asian populations, but data from African populations under-studied—which has implications for drug safety effective use Africa. Results: We identified significant using 458 high-coverage whole genome sequences, 412 which novel, previously available...
It is the goal of Therapeutic Drug Monitoring (TDM) to use drug concentrations manage a patient’s medication regime and optimise outcome. Limited resources require that assays should only be performed when they do contribute patient management. For this case therapeutic monitoring service has far greater role than just measuring . This article describes roles functions Best Practice TDM service. The features which can strived for in each step process—the decision request level, biological...