A5080530790- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders Research
- Neurogenetic and Muscular Disorders Research
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Hip disorders and treatments
- Skin and Cellular Biology Research
- Celiac Disease Research and Management
- Pediatric health and respiratory diseases
- Sports Performance and Training
- Rheumatoid Arthritis Research and Therapies
- Genetic Syndromes and Imprinting
- Injury Epidemiology and Prevention
- Lymphadenopathy Diagnosis and Analysis
- Cardiomyopathy and Myosin Studies
- Occupational Health and Performance
- Medical and Biological Ozone Research
- Sleep and related disorders
- Dermatological and Skeletal Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Coenzyme Q10 studies and effects
- Lower Extremity Biomechanics and Pathologies
Hospital for Sick Children
2008-2025
Abstract Objective To determine the feasibility of conducting a randomized controlled trial 12‐week exercise intervention in children with fibromyalgia (FM) and to explore effectiveness aerobic on physical fitness, function, pain, FM symptoms, quality life (QOL). Methods patients ages 8–18 years were either aerobics or qigong. Both groups participated 3 weekly training sessions. Program adherence safety monitored at each session. Data collected testing sessions, 2 prior 1 after intervention,...
https://youtu.be/G0PzOreB-PI BACKGROUND Juvenile idiopathic inflammatory myopathies (JIIM) are characterized by chronic inflammation of skeletal muscles, muscle weakness and skin rashes. Patients with JIIM have impaired energy metabolism which contributes to the pathophysiology debilitating muscular symptoms. Creatine (Cr) Coenzyme Q10 (CoQ10) supplementation, compounds involved in cellular metabolism, has been shown improve outcomes musculoskeletal diseases similar JIIM. Although exercising...
Objective Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has defined using NanoString technology and appears to correlate with cross-sectional samples JDM patients. This study aimed determine if there is evidence a correlation between IRG-score, patients JDM, both early course longitudinally. Methods All attending clinic SickKids were approached enrol the...
To assess whether there are identifiable subgroups of disease activity trajectory in a population JDM patients-followed throughout childhood and into adulthood-and determine factors that predict those groupings.
Objective. To evaluate the feasibility of studying creatine in juvenile dermatomyositis (JDM). Secondary objectives were to determine effect on muscle function and metabolism, aerobic capacity, fatigue, physical activity, quality life (QOL), as well its safety. Methods. We conducted a 6-month, double-blind, randomized, multiple-baseline design; patients assigned or placebo. Feasibility was assessed using attended study visits, completed procedures, adherence. Muscle function, strength with...
Objective The long-term outcomes of juvenile dermatomyositis (JDM) are more favorable in recent years. However, calcinosis is still among the complications that can cause serious functional impairment. Little known about pathogenesis and risk factors calcinosis. aim this study to determine for development JDM. Methods This was a single-center, retrospective cohort study. All patients were diagnosed followed at multidisciplinary JDM clinic Hospital Sick Children, from January 1, 1989, until...
Objectives Juvenile idiopathic arthritis (JIA) is a common chronic childhood disease and pain debilitating feature. A strong link has been shown between poor sleep in JIA. However, the causal direction unknown. This study’s aim was to determine if, adolescents with JIA, recommended healthful duration leads reductions when compared restricted (RS) that commonly seen. Methods Patients JIA (12–18 years old; score of ≥1 on visual analogue scale) participated randomised, crossover manipulation...
Objective. Juvenile dermatomyositis (JDM) is a rare disease in children that treatable, but patients may suffer from long-term effects. Clinical trials are needed to find better treatments for affected patients. Among validated tools evaluating activity clinically the Disease Activity Score (DAS), it not routinely collected all clinics. We developed modified DAS (DAS mod ), which can be scored using data by our clinical staff and has been used previous studies. The aim of this study was...
Abstract Background Tibial stress injuries are frequent of the lower extremity and most common causes exercise-induced leg pain among athletes military recruits. They sometimes occur in patients with pathological conditions bone metabolism such as osteoporosis or rheumatoid arthritis, but there previously no cases reported juvenile dermatomyositis (JDM). Here we report 6 JDM who presented shin pain, imaging appearance tibial fractures reactions. Case presentation All tenderness anterior...
Juvenile Dermatomyositis (JDM), a severe and rare autoimmune disease, is the most common idiopathic inflammatory myopathy in children. We describe clinical features of large single-centre cohort.We studied an inception cohort (0-18 years old) referred for diagnosis to JDM clinic at The Hospital Sick Children (SickKids), between January 1989 September 2017. Probable or definite was done according 2017 ACR/EULAR Criteria. excluded children who had treatment started another hospital.The data...
Abstract Background Core sets, while widely adopted for clinical assessment in juvenile dermatomyositis (JDM), have some drawbacks – they are time consuming, were developed primarily research, and require an experienced multidisciplinary team. We propose the Wingate Anaerobic Test, a 30-s all out test performed on cycle ergometer, as potential alternative; it is valid reliable this patient population. aimed to determine feasibility of performing part typical clinic visit, if correlated...